Synthesis and characterization of methotrexate nanoparticals

Hassan Hufdhy Abbas; May Talib Flayyih

doi:10.53730/ijhs.v6nS6.12026

Authors

Hassan Hufdhy Abbas
hassanhifdy75@gmail.com
Department of Biology, ᴄollege of Sᴄienᴄe, University of Baghdad, Baghdad, Iraq
May Talib Flayyih Department of Biology, ᴄollege of Sᴄienᴄe, University of Baghdad, Baghdad, Iraq

Keywords:

MTX, MTX NPs, UV-Vis spectra analysis, AFM, SEM, FTIR

Abstract

The MTX was converted to MTX nanoparticles by the modified method based on changing the pH gradually with exposure to ultrasound and shaking , changing the pH with exposure to ultrasound plays an significant role in the formation of nanoparticles, and this is shown in some previous studies. As the change in pH affects the nature of bonding between molecules, as well as the strength of bonding that depends on the change of electrical charges The exposure to ultrasound waves will greatly affect the breakdown of large particles into small particles that reach the level of nanoparticles. The MTX NPs formation was characterized by UV-Vis spectra analysis , Atomic force microscopy (AFM) analysis, Scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR), which indicate that MTX NPs formation was in Nano sized (57.11 nm) with spiny or needle shape.

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