Spectrophotometric determination of Mesalazine by formation of copling with reagent
Keywords:
mesalazine, reagant, 2,6-dichloro indophenol sodiumAbstract
A simple, developed, fast and accurate spectrophotometric method for determination of Mesalazine (MSL) in its pure form and pharmaceutical preparation (Pentasa). This method was based on the formation of complex between MSL and the reagent 2,6-Dichloro indophenol sodium (DIS) to give a red color product that gives ats highest absorption at the wavelength of 520 nm. The best conditions for complex formation were found (time, temperature, optimal reagent concentration, pH). The linearity of the method for the complex consisting ranged from 5-30 µg/ml, the Sandell's index was 0.0354µg/cm2, the molar absorption coefficient was 4318.40L/mol.cm and the detection limit was 0.252µg /ml , the quantitative limit was 0.766 µg/ml , the percent recovery range was Rec% between (98.900-101.715)% and the relative standard deviation rate RSD% between (0.00306- 0.00696)%. It was found that the method was accurate and precision and has been successfully applied to estimate the MSL in its pharmaceutical preparation, in direct methods and in multi standard additions.
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