A relationship of contactin-1 with a number of trace elements in Iraqi rheumatoid arthritis patients with and without COVID-19

Hanaa S. Mahmoud; Shakir F. T. Alaaraji

doi:10.53730/ijhs.v6nS5.12091

Authors

Hanaa S. Mahmoud Department of Chemistry, College of Education for Pure Scienc, University Of Anbar, Ramadi, Iraq
Shakir F. T. Alaaraji Department of Chemistry, College of Education for Pure Scienc, University Of Anbar, Ramadi, Iraq

Keywords:

CNTN-1, rheumatoid Arthritis, COVID-19, trace elements

Abstract

Background: Anti-inflammatory intermediaries like contactin-1 (CNTN-1) play an essential role in regulating several diseases, such as Rheumatoid Arthritis (RA). This paper explores the relationship between CNTN-1 and a number of trace elements in RA patients with and without COVID19. Accordingly, it investigates whether there are any correlations between CNTN-1 and some trace elements. Materials and Methods: The paper involved 56 patients, where 28 suffer from RA without any complications, the other 28 have RA with COVID19 attending Al-Fallujah teaching hospital and 28 healthy persons matching in age, sex and ethnic background as control group. Serum level of contactin-1 was estimated by ELISA technique while Uric acid, urea, creatinine, lipid Profile, zinc, copper, ferrous and magnesium were assessed by colorimetric enzymatic methods. Results: The results demonstrated that Contactin-1 serum concentrations had existed more significantly in patients with and without COVID19. However, RA patients and RA with Covid-19 patients showed lower levels of magnesium (Mg), zinc (Zn), iron (Fe) and Fe/Cu ratio. High serum concentrations of CNTN-1 have been identified and associated positively with ESR and Cu/Zn, while serum concentrations of CNTC-1 were positively related with total cholesterol (TC), triglycerides (TG), copper (Cu), zn and iron (Fe).

Downloads

Download data is not yet available.

References

Ala. S, shokrzadeh. M, Pur shoja. A. et al. (2009). plasma concentrations in Rheumatoid Arthritis patients from a selected population in Iran Pakistan. Journal of biological sciences; 12(14): 1041-1044.

Alaaraji, S.F.T.; Mohisen, M.A.; Awad, M.M. (2020). Assessment serum levels of neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in iraqi rheumatoid arthritis patients Systematic Reviews in Pharmacy; 11(12): 88-93.

Arnett FC, Edworthy SM, Bloch DA, et al. (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid Arthritis. Arthritis Rheum; 31 (3): 315-324.

Brig. M. N, Chatterje. A, Shinde. R. (2005). text book medical biochemistry. Published by jitendar prij; 178-557.

Cerhan. J. R, Saag. K. G, Criswell. L. A. (2003). Antioxidant Micronutrients and Risk of Rheumatoid Arthritis in Cohort of Older women. Am. J. Epidemiol; 157(4): 345-354.

Chatterjee. M, Schild. D, Charlotte E, et al. (2019). Contactins in the central nervous system: role in health and disease. Neural Regen Res; 14 (2): 206–216.

Colak. M, Bingol. N. K, Ayhan. O, et al. (2001). Serum Copper, Zinc and Selenium levels in Rheumatoid Arthritis. Rhomatizma; 16 ( 2):66-71.

Congqi. Hu, Fangfang. Zhu, Lijuan. Liu, et al. (2020). Relationship between dietary magnesium intake and rheumatoid Arthritis in US women: a cross- sectional study, BMJ Open ;10: e039640.

Conway. R, Konig. MF, Graef. ER, et al. (2021). Inflammatory Arthritis in patients with Covid-19. Translational Research; 232: 49-59.

Cucinotta. D, Vanelli. M. (2020). WHO Declares COVID-19 a Pandemic. Acta Biomed; 91(1): 157–160.

Falk. J, Bonnon. C, Girault. J. A, et al. (2002). F3/contactin, a neuronal cell adhesion molecule implicated in axogenesis and myelination. Biol. Cell; 94: 327–334.

Florianczyk B. (2008). Trace elements as constituents of antioxidative proteins. Journal of pre-clinical and clinical research; 2 (1): 25-27.

Gennarini. G, Bizzoca. A, Picocci. S, et al. (2017). The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders. Mol Cell Neurosci; 81:49–63.

Ismail. M. M, Alaaraji. S.F.T. (2020). An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients. Eurasia J Biosci 14: 71-79.

Lengman. M. (2003). safe upper levels for vitamins and minerals Expert group on vitamins and minerals. 164-287.

Majhi. T, Srivastava. A. K. (2010). Iron Deficiency in Rheumatoid Arthritic patients especially with in the middle age. International Journal of systems Biology; 2(1): 1-5.

Öner Özdemir. (2020). Coronavirus Disease 2019 (COVID-19): Diagnosis and Management. Erciyes Med J; 42 (3): 242– 247.

Pasceri. V, Yeh. ET. (1999). A tale of two diseases: atherosclerosis and rheumatoid Arthritis. Circulation; 100(21): 2124-2126.

Rink. L, Haase. H. (2006). Zinc homeostasis and immunity. trends in immunology; 28 (1):1-4.

Satish. K. T, Reshu. M. (2009). Assessment of mineral status (Zn, Cu, Mg and Mn) in Rheumatoid Arthritis patients in Chandigarh, India. Rheumatology Report;1(5):16-20.

Smith. S. M, Donald. A, Webb. D. (1998). Complete Book of vitamins and minerals. Publications International; 210-264

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937

Ullah. Z, Ullah. M. I, Hussain. S, et al. (2017). Determination of Serum Trace Elements (Zn, Cu, and Fe) in Pakistani Patients with Rheumatoid Arthritis. Biol Trace Elem Res; 175 (1): 10-16.

Ullah. Z, Ullah. M. I, Hussain. S, et al. (2017). Determination of Serum Trace Elements (Zn, Cu, and Fe) in Pakistani Patients with Rheumatoid Arthritis. Biol Trace Elem Res;175 (1):10-16.

Veny. M, Grases. D, Kucharova. K, et al. (2020). Contactin-1 Is Required for Peripheral Innervation and Immune Homeostasis Within the Intestinal Mucosa. Front. Immunol; 11:1268.

Widjaja, G. (2021). Impact of human resource management on health workers during pandemics COVID-19: systematic review. International Journal of Health & Medical Sciences, 4(1), 61-68. https://doi.org/10.31295/ijhms.v4n1.850