Evaluating Galectin-3 (LGALS3) +191 gene variant and serum Galectin-3 levels in Egyptian children with familial mediterranean fever

Samia S E. Mahmoud; Huda M. Mohamed; Yomna M. Farag; Mona M. Abdul Salam; Sara I. Falah

doi:10.53730/ijhs.v6nS5.12102

Authors

Samia S E. Mahmoud Department of Pediatrics and Pediatric Rheumatology Faculty of Medicine, Cairo University, Cairo, Egypt
Huda M. Mohamed Department of Pediatrics and Pediatric Rheumatology Faculty of Medicine, Cairo University, Cairo, Egypt
Yomna M. Farag Department of Pediatrics and Pediatric Rheumatology Faculty of Medicine, Cairo University, Cairo, Egypt
Mona M. Abdul Salam Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
Sara I. Falah
sarahfalah40@gmail.com
Department of Pediatrics and Pediatric Rheumatology Faculty of Medicine, Cairo University, Cairo, Egypt

Keywords:

FMF, Galectin-3, Proteinuria, Renal affection, Single Nucleotide Polymorphism

Abstract

Background: The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Aim of the work: to evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of albumin / creatinine ratio (ACR). Results: Serum Galectin-3 levels were significantly higher in FMF patients than control group, P < 0.03. Regarding genotype and allele distribution of (LGALS3) c. 191 C>A polymorphism there was statistical significant difference between cases and control, 13 patients (42%) had CC and the remaining 37 patients (63%) were CA. The control had 18 child (58%) with CC compared to 22 child with CA (37%) and BUN level was higher among CC type of Galectin-3 (LGALS3) c.191 C>A.

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