Evaluation of the circulatory levels of resistin in coronary artery disease with associated co-morbidities

Deepak Ramdas Kamble; Vijay Rajaram Pandhare; Deepali Amarsinh Vidhate; Aarya Amarsinh Vidhate; Haritkumar Vivek; Vidhisha Jariwala; Becky Prakash Thomas; James Thomas

doi:10.53730/ijhs.v6nS7.12132

Authors

Deepak Ramdas Kamble D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Vijay Rajaram Pandhare D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Deepali Amarsinh Vidhate D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Aarya Amarsinh Vidhate D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Haritkumar Vivek D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Vidhisha Jariwala D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India
Becky Prakash Thomas CHRIST (Deemed to be University), India
James Thomas D. Y. Patil Deemed to be University School of Medicine, Nerul, Navi Mumbai-400706, India

Keywords:

Inflammation, Type, Diabetes, Cardiovascular disease, Resistin, Obesity

Abstract

Inflammation is known to be the root cause of the development of coronary artery disease (CAD). Subclinical inflammation is one of the key players in pathophysiology of CAD. An inflammatory response leads to the secretion of various adipokines and cytokines. There are various pro-inflammatory markers which could be used to determine the onset of disease, and one such marker is resistin adipokine. The present study evaluates and compares the circulatory concentration of resistin in CAD patients and controls for the determination of its association with CAD. In this study, 58 CAD patients were enrolled and were further subdivided into four groups as per the associated co-morbidities. Various anthropometric and biochemical parameters were assessed. The circulatory levels of resistin were found to be significantly elevated in CAD patients and their subgroups as compared to controls. We conclude that elevated resistin levels in CAD patients suggest a key role of resistin in the development of CAD. The present study also observed that co-morbidities like type 2 diabetes can act as one of the major factors for the elevated concentration of resistin in the circulation of CAD patients with diabetes.

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