Study on anti-phospholipid syndrome and tumor necrosis factor in woman with recurrent spontaneous abortion in wasit province

Nabaa A. Hasan; Kadhum J. Gattia; Hazem I. Abd Albaree

doi:10.53730/ijhs.v6nS9.12173

Authors

Nabaa A. Hasan
Ali.mario28@yahoo.com
Department of Biology, College of Science, University of Wasit, Wasit, Iraq
Kadhum J. Gattia Department of Biology, College of Science, University of Wasit, Wasit, Iraq
Hazem I. Abd Albaree Biotechnology Research Center, Nahrian University, Baghdad, Iraq

Keywords:

Recurrent spontaneous abortion (RSA), Antiphospholipid syndrome (APS), Tumor Necrosis Factor (TNF)

Abstract

Recurrent spontaneous abortion (RSA) is defined as the loss of pregnancy for at least two respectively times before the fetus reaches the twenty-four week of pregnancy, and its causes are multiple, some of which are known, but 50% of them are still unexplained. Antiphospholipid syndrome (APS), is one of the autoimmune diseases that can cause blood clots and lead to abortionor loss of the fetus in the first trimester of pregnancy. The study included 44 women who had repeated spontaneous abortions (two abortions or more) as well as two control groups (pregnant and healthy) who numbered 44 women, where 22 are naturally pregnant with a period of pregnancy 1-5 months without having had a previous abortionand 22 healthy women who are not pregnant and have given birth at least one child without previous abortions.Antiphspholipid syndrome was found to have a significant effect (p ≤0.05) on abortionfor aborted women to the control group (pregnant and healthy),as well asIt was found that there was a significant rise (p ≤0.05) in the level of tumor necrosis factor for abortions compared to pregnant women.

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References

S. Krieg and L. Westphal, “Immune function and recurrent pregnancy loss,” in Seminars in reproductive medicine, 2015, vol. 33, no. 04, pp. 305–312.

D. J. Wallace, The lupus book: A guide for patients and their families. Oxford University Press, 2019.

I. Uthman, M. H. A. Noureldine, G. Ruiz-Irastorza, and M. Khamashta, “Management of antiphospholipid syndrome,” Ann. Rheum. Dis., vol. 78, no. 2, pp. 155–161, 2019.

U. Gaur and B. B. Aggarwal, “Regulation of proliferation, survival and apoptosis by members of the TNF superfamily,” Biochem. Pharmacol., vol. 66, no. 8, pp. 1403–1408, 2003.

K. Dorovini-Zis, M. Stins, M. S. Desruisseaux, Y. C. Martins, and H. van der Heyde, “The Brain Microvasculature in Cerebral Malaria,” in The Blood-Brain Barrier in Health and Disease, Volume Two, CRC Press, 2015, pp. 82–131.

K. Dimitriadis, M. Wenzel, G. Buchholz, and A. Straube, “Does Pretreatment with a Tumor Necrosis Factor Alpha-inhibitor Improve the Outcome After Ischemic Cerebral Infarction? A Case Report,” Cureus, vol. 11, no. 2, 2019.

M. A. Martínez-Zamora et al., “Higher levels of procoagulant microparticles in women with recurrent abortionare not associated with antiphospholipid antibodies,” Hum. Reprod., vol. 31, no. 1, pp. 46–52, 2016.

K. R. Youngman, “Mechanisms of regulation of polymeric immunoglobulin receptor expression: cytokine induction and tissue specificity.” Case Western Reserve University, 1996.

D. S. Paulson, Biostatistics and microbiology: a survival manual. Springer Science & Business Media, 2008.

F. De Wolf, L. O. Carreras, P. Moerman, J. Vermylen, A. Van Assche, and M. Renaer, “Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant,” Am. J. Obstet. Gynecol., vol. 142, no. 7, pp. 829–834, 1982.

H. A. Mousa and Z. Alfirevic1, “Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome?,” Hum. Reprod., vol. 15, no. 8, pp. 1830–1833, 2000.

Shahad fadhil Abdallah, “Microbial and Molecular study of Antiphospholipid syndrome in woman with Recurrent Abortion.” M.s.c thesis .collage of scince for woman ,university of Babylon., 2019.

K. Mayer-Pickel, “Obesity and an-tiphospholipid syndrome: a particu-lar challenge in pregnancy,” Obes Res Open J, vol. 2, no. 2, pp. 46–56, 2015.

M.-C. Boffa et al., “Laboratory criteria of the obstetrical antiphospholipid syndrome,” Thromb. Haemost., vol. 102, no. 07, pp. 25–28, 2009.

V. Toder, A. Fein, H. Carp, and A. Torchinsky, “TNF-α in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?,” J. Assist. Reprod. Genet., vol. 20, no. 2, pp. 73–81, 2003.

Kurtieva, S. (2021). Adaptation capabilities of functional systems of the body of adolescents with vegetative dystonia syndrome. International Journal of Health & Medical Sciences, 4(1), 129-135. https://doi.org/10.31295/ijhms.v4n1.1622

C. J. Lockwood et al., “Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells,” Biol. Reprod., vol. 78, no. 6, pp. 1064–1072, 2008.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

A.-L. Stefanski, C. Specker, R. Fischer-Betz, W. Henrich, E. Schleussner, and T. Dörner, “Maternal Thrombophilia and Recurrent Abortion–Is There Evidence That Heparin is Indicated as Prophylaxis against Recurrence?,” Geburtshilfe Frauenheilkd., vol. 78, no. 03, pp. 274–282, 2018.

S. Daher et al., “Cytokines in recurrent pregnancy loss,” J. Reprod. Immunol., vol. 62, no. 1–2, pp. 151–157, 2004.

Al-Hassani, M.K.A., Al-Gharban, H.A.J., and Manher, L.F. (2018). Application of Three Diagnostic Serologic Techniques to Detect of Dromedary Camel’s Brucellosis. Al-Qadisiyah journal For pure science, 23 (2), 61-74

F. Y. Azizieh and R. G. Raghupathy, “Tumor necrosis factor-α and pregnancy complications: a prospective study,” Med. Princ. Pract., vol. 24, no. 2, pp. 165–170, 2015.

I. A. Alwan, “Cytokine gene polymorphisms in Iraqi women with unexplained recurrent abortions.” p. Ph.D. thesis, Coll. Sci., Univ. Baghdad, 2016.