Synthesis, identification, and cytotoxicity effect of Oxazapine scaffolding
Keywords:
schiff base, 5-methylpyrazole-3-amino, MDA-231 breast cancer cells, REF 52 cell lineAbstract
The research includes the preparation of two Schiff bases MA (2-1) and some of their derivatives from the reaction of para-bromobenzaldehyde or para-methoxy benzaldehyde with stoichiometric 5-methyl pyrazole-3-amino in the presence of glacial acetic acid. Then the corresponding oxazepine rings MA (6-3) were prepared from each MA (2-1) with maleic anhydride or phthalic anhydride. The prepared chemical formulas were spectroscopically confirmed using FTIR and 1HNMR spectroscopy. The biological activity of MA5 had tested against MDA breast cancer and REF healthy cells at seven concentrations (500,250,125,62.5,31.5,15.5,7.5) µg / ml. The compound showed a high inhibition against cancer cells, so this makes it a candidate as a drug for future cytotoxicity.
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References
Abed, R. R., & Ahmed, A. E. (2021). Some complexes of Zink (II) and Manganese (II) with schiff base derived from nicotinamide, synthesis and characterization, antibacterial evaluation. Research Journal of Pharmacy and Technology, 14(3), 1711-1715.
Aftan, M. M., Jabbar, M. Q., Dalaf, A. H., & Salih, H. K. (2021). Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior. Materials Today: Proceedings, 43, 2040-2050.
Alfraiji, R. A., Alrecabi, Z. G., & Al-Majidi, S. M. (2017). Synthesis, Identification of Some New Derivatives of Oxazpine, Thiazinone and Hydroquinazoline and Evaluation of Antibacterial Activity. Iraqi Journal of Science, 1565-1579.
Al-lami, N., & Salom, K. J. (2019). Pharmacological studies on some new 3-cyclic oxazepine-2-aryl imidazo (1, 2-a) pyridine derivatives. Journal of Pharmaceutical Sciences and Research, 11(1), 125-130.
Bozorov, K., Zhao, J., & Aisa, H. A. (2019). 1, 2, 3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview. Bioorganic & medicinal chemistry, 27(16), 3511-3531.
Jirjees, I. Design and characterization of oxazepine new drivaives. International Journal of Health Sciences, (II), 7380-7387.
Mishra, R., Kumar, N., Mishra, I., & Sachan, N. (2020). A review on anticancer activities of thiophene and its analogs. Mini Reviews in Medicinal Chemistry, 20(19), 1944-1965.
Mohi, A. T., Ismail Al-Rubaye, H., Weli Askar, F., & Jassim Abboud, H. (2020). Synthesis, Theoretical and antimicrobial activity study of new benzimidazole derivatives. Egyptian Journal of Chemistry, 63(8), 2877-2886.
Muslim, R. F., & Owaid, M. N. (2019). Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from Cyperus sp. rhizomes. ACTA Pharmaceutica Sciencia, 57(2).
Nief, O. A. (2017). Synthesis and Identification of Heterocyclic Compounds (Oxazepine, Tetrazole) Derived from Benzidine as Photostabilizing for Poly vinyl chloride. Al-Mustansiriyah Journal of Science, 28(2), 108-118.
Samir, A. H., Rumez, R. M., & Fadhil, H. A. (2017). Synthesis and characterization of some new oxazepine compounds containing 1, 3, 4-thiadiazole ring derived form d-erythroascorbic acid. International Journal of Applied Chemistry, 13(3), 393-407.
Shaabani, S., Shaabani, A., Kucerakova, M., & Dusek, M. (2019). A One-Pot synthesis of oxazepine-quinazolinone bis-heterocyclic scaffolds via isocyanide-based three-component reactions. Frontiers in chemistry, 7, 623.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Thaib, P. K. P., & Rahaju, A. S. (2022). Clinicopathological profile of clear cell renal cell carcinoma. International Journal of Health & Medical Sciences, 5(1), 91-100. https://doi.org/10.21744/ijhms.v5n1.1846
Wu, X., Zhang, Y., Liu, S., Liu, C., Tang, G., Cao, X., ... & Peng, J. (2022). Research applications of “linkers” in small molecule drugs design in fragment-based. Bioorganic Chemistry, 105921.
Wu, Y., Yuan, C., Wang, C., Mao, B., Jia, H., Gao, X., ... & Guo, H. (2017). Palladium-Catalyzed [5+ 2] Cycloaddition of Vinyloxiranes with Sulfamate-Derived Cyclic Imines To Construct 1, 3-Oxazepine Heterocycles. Organic letters, 19(23), 6268-6271.
Yokota, T., & Hontani, H. (2018, November). Tensor completion with shift-invariant cosine bases. In 2018 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC) (pp. 1325-1333). IEEE.
Zhou, L. M., Qu, R. Y., & Yang, G. F. (2020). An overview of spirooxindole as a promising scaffold for novel drug discovery. Expert Opinion on Drug Discovery, 15(5), 603-625.
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