Clinical comparison of antioxidant for pregnant women with iron deficiency anemia

Zinah Naeem Mtele

doi:10.53730/ijhs.v6nS9.12286

Authors

Zinah Naeem Mtele
Zenahalawadi@gmail.com
Directorate of Education Thi Qar, Ministry of Education, Iraq

Keywords:

pregnant women, antioxidation, anemia

Abstract

The aim of this study was to study the evaluation of serum antioxidation in pregnant women with iron deficiency anemia by measuring to measure some antioxidant parameters including: ceruloplasmin (Cp), copper (Cu) and transferrin (Tf) levels in pregnant women with iron deficiency anemia. Blood samples were obtained from (80) pregnant women with anemia divided according to the stage of pregnancy and iron deficiency as follows: 1) Twenty patients in the second trimester with anemia without iron deficiency; 2) Twenty patients in the second trimester with anemia with iron deficiency; 3) Twenty patients In the third trimester with anemia without iron deficiency; 4) Twenty patients in the third trimester have anemia with iron deficiency. In addition, a control group of (40) healthy pregnant women was used. Twenty pregnant in the second trimester and 20 pregnant in the third trimester were divided into two groups. Results: The results show a presence of a significant increase in Cp, Cu and Tf in all groups of patients with Iron deficiency in comparison with control group.

Downloads

Download data is not yet available.

References

Ayuanda, L. N., Wahidin, W., Raidanti, D., Minarti, M., & Ningsih, D. A. (2022). Online midwife’s training on psychoeducation of perinatal mental health during COVID-19 Pandemic. International Journal of Social Sciences and Humanities, 6(1), 85–97. https://doi.org/10.53730/ijssh.v6n1.4741

B. H. Al–Wihaly, “Comparative Biochemical Study of Glutathione, Ceruloplasmin and Trace Element in Sera of Control Group and Human Female Patients with Osteoarthritis Nodal in Iraqies Patients,” Ibn AL-Haitham J. Pure Appl. Sci., vol. 23, no. 2, pp. 33–38, 2017.

B. Halliwell and J. M. C. Gutteridge, “Free radicals in biology and medicine.” Pergamon, 1985.

B.-E. Kim, T. Nevitt, and D. J. Thiele, “Mechanisms for copper acquisition, distribution and regulation,” Nat. Chem. Biol., vol. 4, no. 3, pp. 176–185, 2008, doi: 10.1038/nchembio.72.

C. Breymann, “Iron deficiency anemia in pregnancy,” Expert Rev. Obstet. Gynecol., vol. 8, no. 6, pp. 587–596, 2013.

C. Brugnara, “Iron deficiency and erythropoiesis: new diagnostic approaches,” Clin. Chem., vol. 49, no. 10, pp. 1573–1578, 2003.

E. Buonomo, F. Cenko, A. M. Altan, A. Godo, M. C. Marazzi, and L. Palombi, “Iron deficiency anemia and feeding practices in Albanian children.,” Ann. di Ig. Med. Prev. e di Comunità, vol. 17, no. 1, pp. 27–33, 2005.

E. McLean, M. Cogswell, I. Egli, D. Wojdyla, and B. De Benoist, “Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005,” Public Health Nutr., vol. 12, no. 4, pp. 444–454, 2009.

F. M. Tabrizi and F. G. Pakdel, “Serum level of some minerals during three trimesters of pregnancy in Iranian women and their newborns: a longitudinal study,” Indian J. Clin. Biochem., vol. 29, no. 2, pp. 174–180, 2014.

G. J. Anderson, D. M. Frazer, A. T. McKie, and C. D. Vulpe, “The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption,” Blood Cells, Mol. Dis., vol. 29, no. 3, pp. 367–375, 2002.

H. Chun, A. K. Sharma, J. Lee, J. Chan, S. Jia, and B. E. Kim, “The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans,” J. Biol. Chem., vol. 292, no. 1, pp. 1–14, 2017, doi: 10.1074/jbc.M116.760876.

I. Al Hifzi, R. K. Pejaver, and I. Qureshi, “Screening for iron deficiency anemia in a well baby clinic,” Ann. Saudi Med., vol. 16, no. 6, pp. 622–624, 1996.

I. De Domenico et al., “Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin,” EMBO J., vol. 26, no. 12, pp. 2823–2831, 2007, doi: 10.1038/sj.emboj.7601735.

I. Thorsdottir, B. S. Gunnarsson, H. Atladottir, K. F. Michaelsen, and G. Palsson, “Iron status at 12 months of age—effects of body size, growth and diet in a population with high birth weight,” Eur. J. Clin. Nutr., vol. 57, no. 4, pp. 505–513, 2003.

J. A. S. Herruzo and P. S. Muñoz, “Non-HFE hemochromatosis,” vol. 97, no. 16, pp. 266–278, 2005.

J. M. Brotanek, J. Gosz, M. Weitzman, and G. Flores, “Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities,” Pediatrics, vol. 120, no. 3, pp. 568–575, 2007.

J. R. Turnlund, C. A. Swanson, and J. C. King, “Copper absorption and retention in pregnant women fed diets based on animal and plant proteins,” J. Nutr., vol. 113, no. 11, pp. 2346–2352, 1983.

J. W. Choi, M. W. Im, and S. H. Pai, “Serum transferrin receptor concentrations during normal pregnancy,” Clin. Chem., vol. 46, no. 5, pp. 725–727, 2000.

M. C. Linder and M. Hazegh-Azam, “Copper biochemistry and molecular biology,” Am. J. Clin. Nutr., vol. 63, no. 5, pp. 797S-811S, 1996.

M. Naithani, J. Bharadwaj, and A. Garg, “Study of relation between serum iron and copper levels in pregnant females of Uttarakhand, India,” Acta Medica Int., vol. 3, no. 1, p. 83, 2016.

M. Vostrejs, P. L. Moran, and P. A. Seligman, “Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation.,” J. Clin. Invest., vol. 82, no. 1, pp. 331–339, 1988.

P. B. Rao, P. Modi, and A. K. Modi, “Serum ceruloplasmin levels in pregnant women,” Int. J. Pharm. Med. Res, vol. 3, no. 2, pp. 57–60, 2015.

P. Benito and D. Miller, “Iron absorption and bioavailability: an updated review,” Nutr. Res., vol. 18, no. 3, pp. 581–603, 1998.

P. Cacoub, C. Vandewalle, and K. Peoc’h, “Using transferrin saturation as a diagnostic criterion for iron deficiency: A systematic review,” Crit. Rev. Clin. Lab. Sci., vol. 56, no. 8, pp. 526–532, 2019.

P. N. Ranganathan, Y. Lu, L. Jiang, C. Kim, and J. F. Collins, “Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake,” Blood, J. Am. Soc. Hematol., vol. 118, no. 11, pp. 3146–3153, 2011.

Rahmadhani, W., Kusumastuti, K., & Chamroen, P. (2022). Prevalence and determinants of postpartum depression among adolescent mothers: A cross-sectional study. International Journal of Health Sciences, 6(2), 533–544. https://doi.org/10.53730/ijhs.v6n2.6422

S. Derouiche, A. Kawther, D. Manel, B. A. Soumya, and Z. Kechrid, “The effects of copper supplement on zinc status, enzymes of zinc activities and antioxidant status in alloxan-induced diabetic rats fed on zinc over-dose diet,” Int. J. Nutr. Metab., vol. 5, no. 5, pp. 82–87, 2013.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

T. Thomas, B. R. Southwell, G. Schreiber, and A. Jaworowski, “Plasma protein synthesis and secretion in the visceral yolk sac of the fetal rat: gene expression, protein synthesis and secretion,” Placenta, vol. 11, no. 5, pp. 413–430, 1990.