Synthesis and antimicrobial activity of new 1,2,3,4-tetrahydropyrimidine-5-carbonyl glycinate silver nanoparticle derivatives
Keywords:
tetrahydropyrimdine, biginelli multi-component reaction, Sliver nanoparticle, Scanning Electron Microscopy, antimicrobialAbstract
A series of silver nanoparticle (AgNPs) with 1,2,3,4 tetrahydropyrimidine derivatives were synthesized and elucidate their structures using physical and spectroscopic techniques (UV.VIS, FTIR, NMR, X-ray diffraction, and SEM). Each of these novel compounds produced spectroscopic data that matched the suggested structures. Pathogenic bacteria and C.albicans were used as test subjects for the antimicrobial activity by using agar well diffusion assay. The AgNPs agents show intermediate activity antimicrobial activities as compare with ciprofloxacin as positive control.
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M. Priya, R. K. Selvan, B. Senthilkumar, M. K. Satheeshkumar, and C. Sanjeeviraja, “Synthesis and characterization of CdWO4 nanocrystals,” Ceramics International, vol. 2011 ; 37(7):2485–2488.
Akl M Awwad, Nidá M Salem and Amany O Abdeen. Green synthesis of silver nanoparticles using carob leaf extract and its antibacterial activity. International Journal of Industrial Chemistry. 2013; 4:29.
Alakbar E. Huseynzada, Christian Jelch, Haji Vahid N. Akhundzada, Sarra Soudani, Cherif Ben Nasr, Aygun Israyilova, Filippo Doria, Ulviyya A. Hasanova, Rana F. Khankishiyeva and Mauro Freccero. Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products. RSC Adv. 2021; 11:6312-6329.
Ali, I. H., Jabir, M. S., Al-Shmgani, H. S., Sulaiman, G. M., and Sadoon. Pathological And immunological study on infection with escherichia coli in ale balb/c mice. Journal of Physics. 2018, 1003(1), 12009.
Amritpal Kaura , Simran Preetb , Vivek Kumarc , Rajeev Kumard and Rajesh Kumar. Synergetic Effect of Vancomycin Loaded Silver Nanoparticles for Enhanced Antibacterial Activity. Colloids and Surfaces B: Biointerfaces. 2018.
Bahjat, H. H., Ismail, R. A., Sulaiman, G. M., and Jabir, M. S. Magnetic field-assisted laser ablation of titanium dioxide nanoparticles in water for anti-bacterial applications. Journal of Inorganic and Organometallic Polymers and Materials. 2021: 1-8.
Basavaraj Padmashali, Ballekere Nanjundaswamy Chidananda and Banuprakash Govindappa. Synthesis and characterization of novel 1,6-dihydropyrimidine derivatives for their pharmacological properties. 2019; 9(05): 133-140.
Bosshard, H. H.; Mory, R.; Schmid, M.; Zollinger, H. Helv. “Advanced Organic Chemistry, Reaction Mechanisms; Harcourt/Academic: San Diego. 2002; 239.
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate. Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate. ACS Omega. 2019; 4:22313−22324.
El-Dash, Y.; Elzayat, E.; Abdou, A.M.; Hassan, R.A. Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition. Bioorg. Chem. 2021, 114, 105137.
Erum Dilshad, Mehmoona Bibi, Nadeem Ahmed Sheikh, Khairul Fikri Tamrin, Qaisar Mansoor, Qaisar Maqbool and Muhammad Nawaz. Synthesis of Functional Silver Nanoparticles and Microparticles with Modifiers and Evaluation of Their Antimicrobial, Anticancer, and Antioxidant Activity. J. Funct. Biomater. 2020; 11, 76.
Evanoff, D.D.; Chumanov, G. Size-controlled synthesis of nanoparticles. 2. Measurement of extinction, scattering, and absorption cross sections. J. Phys. Chem. B. 2004; 108:13957–13962.
Fissan, H.; Ristig, S.; Kaminski, H.; Asbach, C.; Epple, M. Comparison of different characterization methods for nanoparticle dispersions before and after aerosolization. Anal. Methods 2014; 6:7324–7334.
Guyue Cheng, Menghong Dai , Saeed Ahmed, Haihong Hao, Xu Wang and Zonghui Yuan. Antimicrobial Drugs in Fighting against Antimicrobial Resistance, Front. Microbiol. 2016; 7:470.
Hnagarajaiah, Imtiyaz Ahmed M. Khazi and Noor Shahina. Synthesis of some new derivatives of thiazolopyrimidines and hydrolysis of its arylidene derivative. 2015; 127(3): 467–479.
Jang, H.J.; Kim, S.M.; Rho, M.C.; Lee, S.W.; Song, Y.H. Synthesis of thienopyrimidine derivatives as inhibitors of STAT3 activation induced by IL-6. J. Microbiol. Biotechnol. 2019, 29, 856–862.
Jihad, M. A., Noori, F., Jabir, M. S., Albukhaty, S., AlMalki, F. A., and Alyamani, A. A. Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa extract: A Smart Antibacterial Therapeutic Drug Delivery System. Molecules. 2021; 26(11), 3067.
Johal, M.S. Understanding Nanomaterials; CRC Press: Boca Raton, FL, USA, 2011.
Jose Vega-Baudrit, Stephanie Marin Gamboa, Ericka Rodriguez Rojas and Veronica Vega Martinez. Synthesis and characterization of silver nanoparticles and their application as an antibacterial agent. International Journal of Biosensors & Bioelectronics. 2019; 5(5):166-173.
Khashan, K. S., Abdulameer, F. A., Jabir, M. S., Hadi, A. A., and Sulaiman, G. M. Anticancer activity and toxicity of carbon nanoparticles produced by pulsed laser ablation of graphite in water. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2021; 11(3), 035010.
Khashan, K. S., Badr, B. A., Sulaiman, G. M., Jabir, M. S., and Hussain, S. A. Antibacterial activity of Zinc Oxide nanostructured materials synthesis by laser ablation method. In Journal of Physics: Conference Series. 2021; 1795(1), 012040.
Kumar, B.; Smita, K.; Cumbal, L.; Debut, A. Green synthesis of silver nanoparticles using Andean blackberry fruit extract. Saudi J. Biol. Sci. 2017; 24:45–50.
Lin, P.C.; Lin, S.; Wang, P.C.; Sridhar, R. Techniques for physicochemical characterization of nanomaterials. Biotechnol. Adv. 2014; 32:711–726.
Mafaldo-Gómez, D. A., & Reyes-Meza, O. B. (2022). Training in values in environmental education in high school students: Case study: Education, environment, and society. International Journal of Life Sciences, 6(2), 65–71. https://doi.org/10.53730/ijls.v6n2.10561
Marambio-Jones, C.; Hoek, E.M.V. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J. Nanopart. Res. 2010; 12:1531–1551.
Marek K. Grzegorz S., Jerzy K., Szymon U., Mariusz B. , Tomasz B ˛Aczek, A.S., Katarzyna S., Bernadeta S. , Gabriel N., Beata D., and Franciszek H. Synthesis of Novel Pyrido[1,2-c]pyrimidine Derivatives with 6-Fluoro-3-(4-piperidynyl)-1,2-benzisoxazole Moiety as Potential SSRI and 5-HT1A Receptor Ligands. Int. J. Mol. Sci.2021; 22(5): 2329.
Martínez-Castañón, G.; Niño-Martínez, N.; Loyola-Rodríguez, J.; Patiño-Marín, N.; Martínez-Mendoza, J.; Ruiz, F. Synthesis of silver particles with different sizes and morphologies. Mater. Lett. 2009; 63:1266–1268.
Mohammed, M. K., Mohammad, M. R., Jabir, M. S., and Ahmed, D. S. Functionalization, characterization, and antibacterial activity of single wall and multi wall carbon nanotubes. In IOP Conference Series: Materials Science and Engineering. 2020; 757(1), 012028.
Olayinka O. Ajani, Fisayo E. Owolabi, Emmanuel G. Jolayemi, Oluwatosin Y. Audu and Olatunde M. Ogunleye. Facile synthesis of N’-(anthracen-9(10H)-ylidene)-4-(4- hydrophenyl)-6-methyl-2-oxo-1,2,3,4-tetra hydropyrimidine5-carbohydrazide and other derivate. Journal of Physics: Conf. Series 1299. 2019; 012116.
Prem Santhi Yerragopu1, Sharanagouda Hiregoudar1and Udaykumar Nidon. Chemical Synthesis of Silver Nanoparticles Using Tri-sodium Citrate, Stability Study and Their Characterization. International Research Journal of Pure & Applied Chemistry. 2020; 21(3): 37-50.
Rahmadeni, A. S. ., Hayat, N. ., Alba, A. D. ., Badri, I. A. ., & Fadhila, F. . (2020). The relationship of family social support with depression levels of elderly in 2019 . International Journal of Health & Medical Sciences, 3(1), 111-116. https://doi.org/10.31295/ijhms.v3n1.188
Rana R, Sharma R, Kumar A. Repurposing of Existing Statin drugs for treatment of Microbial Infections: How much Promising? Infect Disord DrugTargets. 2018.
Rostampour Esmail, Alihosseini Afshar, Milani Morteza, Akbarzadeh Abolfazl & Ebrahim Akhondi. Synthesis of silver nanoparticles with high efficiency and stability by culture supernatant of Bacillus ROM6 isolated from Zarshouran gold mine and evaluating its antibacterial effects. BMC Microbiology. 2022; 22:97.
Sayed K. Ramadan, Eman A. E. El-Helw and Hanan A. Sallam. Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. De Gruyter Heterocycl. Commun. 2019; 25:107–115.
Shabnam Pourmoslemi, Shirin Moradkhani, Pari Tamri and Sahar Foroughinia. Evaluation of synergistic antibacterial effect of combined scrophularia striata extract and antibiotics against pseudomonas aeruginosaandMethicillin -Resistant Staphylococcus aureus. Iraqi J. Pharm. Sci. 2021; 30(2) .
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Thi Thoi Bui1, Dai Quang Ngo and Van Loc Tran. Synthesis of sulfonylurea derivatives and their α-glucosidase inhibitory activity. Vietnam journal of science,technology and engineering. 2020; 62(2):34-37.
Wang, Z.L. transmission electron microscopy of shape-controlled nanocrystals and their assemblies. J. Phys. Chem. B. 2000; 104:1153–1175.
Wiley, B.; Sun, Y.; Mayers, B.; Xia, Y. Shape-controlled synthesis of metal nanostructures: The case of silver. Chem. Eur. J. 2005; 11:454–463.
Yao, H.; Kimura, K. Field emission scanning electron microscopy for structural characterization of 3D gold nanoparticle super lattices. In Modern Research and Educational Topics in Microscopy; Méndez-Vilas, A., Díaz, J., Eds.; Formatex Research Center: Badajoz, Spain, 2007; 568–575.
Younus, A., Al-Ahmer, S., and Jabir, M. Evaluation of some immunological markers in children with bacterial meningitis caused by Streptococcus pneumonia. Research Journal of Biotechnology. 2019; 14: 131-133.
Zhuang, J.; Ma, S. Recent Development of pyrimidine-containing antimicrobial agents. Chem Med Chem 2020, 15, 1875–1886.
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