Biological activity against breast cancer cells of iron(II), copper(II) & nickel(II) complexes with Di-m-bromobenzalcyclohexanone & dibenzalcyclohexanone - thiosemicarbazide schiff bases
Keywords:
Breast Cancer, Metal Complexes, Biological Activity, Schiff BasesAbstract
The title work included synthesis of new symmetrical dibenzalcyclohexanone substituted with one bromine group at meta position of each benzene ring. The synthesised ketones were dibenzalcyclohexanone and di-m-bromobenzalcyclohexanone. Di-m-bromobenzalcyclohexanone was synthesised through the reaction of cyclohexanone with benzaldehyde in the presence of potassium hydroxide, as well as the preparation of ketones substituted with bromine at meta position from the reaction of cyclohexanone with the substituted benzaldehyde at meta position. The synthesised chalcones were characterized using different spectral and physical techniques. These ketones were used to prepare new Schiff bases by reacting the thiosemicarbazide compound with the previously mentioned un-substituted chalcone, first ligand, while the second ligand was prepared by reacting the meta-bromobenzalcyclohexanone with thiosemicarbazide. The synthesised ligands were bi-dentate ligand, according to this matter six metal complexes were synthesised through reacting two moles of Schiff bases with one mole of nickel (II), iron (II), & copper (II) chlorides. The novel metal complexes were characterized by different techniques such as 1H&13C-NMR and mass spectrometry (Mass Spectra) in addition to measurements of magnetic susceptibility and molar conductivity of the prepared complexes. Through spectroscopic studies and magnetic susceptibility, and physical properties, the shape of the prepared complexes were predicted.
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