Effects of antineoplastic drugs on oxidative stress and prognosis of hematological and various biochemical parameters in the treatment of breast cancer

Sri Phani TejaswiPullakanam; Murugan Mannangatti; Ramakrishna Nekkala; Venkata B. Madhavi; Ravi Shankar Bellala

doi:10.53730/ijhs.v6nS6.12464

Authors

Sri Phani TejaswiPullakanam
tejaswip223@gmail.com
Research Scholar, Department of Biochemistry, AarupadaiVeedu Medical College & Hospital. Vinayaka Mission‘s Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India
Murugan Mannangatti Professor, Department of Biochemistry, AarupadaiVeedu Medical College & Hospital, Vinayaka Mission’s Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India
Ramakrishna Nekkala Professor and Head, Department of Biochemistry, GayatriVidyaParishad Institute of Health Care and Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India
Venkata Madhavi B. Professor, Department of Pathology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India
Ravi Shankar Bellala Head of Clinical Oncology, Omega Hospital, Visakhapatnam, Andhra Pradesh, India

Keywords:

breast cancer, AC (Adriamycin cyclophosphamide), oxidative stress, chemotherapy/Treatment

Abstract

Objective: This study aimed to to evaluate the variation and importance of certain hematological, enzymatic, and oxidative stress markers in women with breast cancer under chemotherapy treatment. Methods: The study comprised forty histopathologically proven female breast cancer patients at Omega Cancer Hospital in Visakhapatnam. All subjects were divided into four groups: a control group of 40 healthy females of similar age, a group of 40 breast cancer patients (before chemotherapy, during chemotherapy, and after chemotherapy), and all subjects were undergoing treatment with anticancer agents. Results: During chemotherapy, lipid peroxidation and Nitric oxide (NO) levels were significantly increased in AC-treated breast cancer patients than in controls. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were non-significant increase in treatment group than controls. Whereas biochemical profiles, were decreased in treatment group than controls. In AC-treated breast cancer patients, Hematological profiles were found significantly reduced than in controls. Conclusion: Chemotherapy causes a certain amount of systemic oxidative stress, which persists during subsequent clinical interventions and may influence the patients' clinical outcomes. Chemotherapy produced significant adverse effects such as anaemia, neutropenia, leukopenia, thrombocytopenia, and hepatic dysfunction as a side effect of treatment due to disturbed and lowered levels of haematological parameters.breast cancer

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References

Abdel-Salam OME, Youness ER, Hafez HF. The antioxidant status of the plasma in patients with breast cancer undergoing chemotherapy. Open J MolIntegrPhysiol 2011; 1, 29–35.

Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6.

Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biological Research 2017; 50(1):33.

Aldini G, Yeum KJ, Niki E, Russell R. Biomarkers for antioxidant defense and oxidative damage: principles and practical applications. 2010. Wiley-Blackwell, USA.

Amin KA, Mohamed BA, Mohamed A M, Ibrahim SO. Impact of Breast Cancer and Combination Chemotherapy on Oxidative Stress, Hepatic and Cardiac Markers. J Breast Cancer. 2012;15(3):306-12.

Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res-DordR2008; 25(9):2097-116

Benzie IRF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Anal Biochem. 1996; 239:70-6.

Brown JE, Cook RJ, Lipton A, Coleman RE. Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients. Clin Cancer Res. 2012;18:6348-6355.

Brown NS, Bicknell R. Hypoxia and oxidative stress in breast cancer-Oxidative stress: Its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 2001;3:323-27.

Carrano AV, Natarajan AT. Considerations for population monitoring using cytogenetic techniques. International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC publication 14). Mutation Research. Vol. 204, no. 3: 379–406, 1988.

Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by kinetic cadmium reduction method. Clin chem.1990;36(8):1440-3.

Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia; risks, consequences, and new directions for its management. American Cancer Society 2003;228-37.

Doroshow JH, Davies KJA. Redox cycling of anthracyclines by cardiac mitochondria: formation of superoxide anion, hydrogen peroxide and hydroxyl radical. J BiolChem1986; 261(7):3068-74.

Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A, Behnam B. Crosstalk between breast cancer stem cells and metastatic niche:emerging molecular metastasis pathway? Tumor Biol. 2013;34:2019–30.

Gönenç A, Erten D, Aslan S. Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease. Cell BiolInt 2006; 30, 376–80.

Günel N, Coskun U, Sancak B, Hasdemir O, Sare M, Bayram O, et al. Prognostic value of serum IL18 and nitric oxide activity in breast cancer patients at operable stage. Am J ClinOncol. 2003;26(4):416- 21.

Hauck AK, Bernlohr DA. Oxidative stress and lipotoxicity. J Lipid Res 2016; 57, 1976–86.

Henderson IC, Berry DA, Demetri GD, Cirrincione CT, Goldstein LJ, Martino S, Ingle JN, Cooper MR, Hayes DF, Tkaczuk KH. Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. Journal of Clinical Oncology 2003;21(6): 976-983.

Hoffmann H, Hogel J, Split G. The effect of smoking on DNA effects in the comet assay: a meta-analysis. Mutagenesis, vol. 20, no. 6:455–466, 2005.

Jasek AM, Day HJ. Acute spontaneous tumor lysis syndrome. American Journal of Hematology 1994;47(2):129-131.

Kind PR, Gordon M, Leverich M, &Slavin BM. The effect of C3H mouse mammary tumor on the levels of serum and urine analyses in vivo. British Journal of Cancer 1985; 52: 607- 611.

Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev PharmacolToxicol 2004;44: 239-267.

Konukoglu D, Turhan MS, Celik V, Turna H. Relation of serum vascular endothelial growth factor as an angiogenesis biomarker with nitric oxide and urokinase-type plasminogen activator in breast cancer patients. Ind J Med Res. 2007;125(6):747-51.

Kyu HH, Bachman VF, Alexander LT, et al. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study. BMJ 2016; 354:3857.

Leanna JS. Immune defects in breast cancer patients after radiotherapy. Journal of the Society for Integrative Oncology 2008;110-121.

Look MP, Musch E. Lipid peroxides in the polychemotherapy of cancer patients. Chemotherapy. 1994;40:8–15.

Niki E. Lipid peroxidation: physiological levels and dual biological effects. Free Radica Biol Med 2009; 47:469-484.

Olufem AE, Oguntola OA, Adeoti S,Layiwola M, AkintolaAA.Hematological Parameters in Female Breast Cancer Patients in SouthwesternNigeria. J Med Health Sci. 2013; 2(4): 398-401.

Sanchez-Suarez P, Ostrosky-Wegman P, Gallegos-Hernandez F. DNA damage in peripheral blood lymphocytes in patients during combined chemotherapy for breast cancer. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. Vol. 640, no. 1-2:8–15, 1997.

Savini I, Gasperi V, Catani MV. Oxidative stress and obesity. Obesity. Cham, Springer International Publishing. 2016; 65–86.

Silverberg E, Lubera J. Cancer statistics. CA-A Journal for Clinician. 1986;36:9- 25.

Sreenivasa Rao CS, SaralaKumari D, Kumari DS. Changes in plasma lipid peroxidation and the antioxidant system in women with breast cancer. Int J Basic ApplSci 2012;1, 429–38.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Suryatika, I. B. M., Poniman, S., Manuaba, I. B. P., Yasa, I. W. P. S., & Sutapa, G. N. (2021). The potential cancer risk on body organs as abdomen CT-scan exposure result. International Journal of Life Sciences, 5(3), 171–178. https://doi.org/10.53730/ijls.v5n3.1721

Thaib, P. K. P., & Rahaju, A. S. (2022). Clinicopathological profile of clear cell renal cell carcinoma. International Journal of Health & Medical Sciences, 5(1), 91-100. https://doi.org/10.21744/ijhms.v5n1.1846

Tuma DJ. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free RadicBiol Med 2002; 32, 303–8.

Vaghef H, Nygren P, Edling C, Bergh J, Hellman B. Alkaline single-cell gel electrophoresis and human biomonitoring for genotoxicity: a pilot study on breast cancer patients undergoing chemotherapy including cyclophosphamide. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. Vol. 395, no. 2-3:127–138, 1997.

Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007;39:44–84. [PubMed]

Varma M, Sahu A, Paneri S, Kachhawa K. Study of BMI, Lipid Profile and CBC in Women having Breast Cancer, Sri Aurobindo Institute of Medical Sciences, Indore. India. Journal of Pure and Applied Microbiology 2014;8(6): 4827-4831.

WHO. Latest global cancer data international agency on cancer. 2018; (press release No 263):201.

Zhang G, Liu Z, Qin S, Li K. Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer. European journal of gynaecological oncology 2015;36(6):629-632.