Assessment of malnutrition in patient with liver cirrhosis and its association with dietary intake

Nawal Al Khalidy; Abeer Adnan Hasan; Zena Khalaf Jasim

doi:10.53730/ijhs.v6nS7.12469

Authors

Nawal Al Khalidy GIT consultant, MBCHB, CABM, FICMS(GE & H). Iraqi Ministry of Health and Environment, City of Medicine Hospital, Baghdad, Iraq
Abeer Adnan Hasan Family medicine specialist and clinical dietition, MBCHB, FABCHS\FM. Iraqi Ministry of Health and Environment, City of Medicine Hospital, Baghdad, Iraq
Zena Khalaf Jasim Family medicine specialist and clinical dietition, MBCHB, FABCHS\FM. Iraqi Ministry of Health and Environment, City of Medicine Hospital, Baghdad, Iraq

Keywords:

NAFLD, Cross-sectional study, malnutrition in patient

Abstract

Introduction: Cirrhosis is incurable, irreversible chronic liver disease and impose a health and economic burden. Malnutrition is related to the progression of liver dysfunction and it is associated with many complications. The current study aims to perform a nutritional assessment for patients with liver cirrhosis using SGA, and study the relationship between protein energy malnutrition and severity of liver cirrhosis using Child-Pugh score. Patients and methods: Cross-sectional study was conducted in Baghdad medical city for 4 months on 50 liver cirrhotic patients. Patients were interviewed, recall diet history, current nutritional requirement, SGA and Child-Pugh score were calculated for each patient, p value ≤ 0.05 were considered significant Results: The average age was 54.7±14.7 years. Majority were men, married, of primary or less education, living in urban settings. NAFLD (34%) and alcohol (32%) were the leading causes. Twenty-nine (58%) had sever disease and 16 (32%) were malnourished. The study showed a significant association between severity of disease and patients’ state of nutrition.

Downloads

Download data is not yet available.

References

Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world.J Hepatol.2019;70(1):151-171.

Wiegand J, Berg T.The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis. Dtsch Arztebl Int. 2013;110(6):85-91.

Buechler C, Haberl EM, Rein-Fischboeck L, Aslanidis C. Adipokines in Liver Cirrhosis.Int J Mol Sci. 2017 Jun 29; 18(7)

Yoshiji H, Nagoshi S, Akahane T,etal. Evidence-based clinical practice guidelines for Liver Cirrhosis. J Gastroenterol.2021;56(7):593-619.

Pimpin L, Cortez-Pinto H, Negro F, Corbould E, Lazarus JV, Webber L etal.Burden of liver disease in Europe:Epidemiology and analysis of risk factors to identify prevention policies.JHepatol.2018;69(3):718-735.

Zhai M, Long J, Liu S.The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017.Aging. 2021;13(1):279-300.

Al-Khazraji K,Hashim M,Hashim M, Abdulla M, Khudhair I, Abbas W. Etiologies of Liver Cirrhosis and Clinical Presentation among Inpatients in Medical City Complex-Baghdad Teaching Hospital.Global Journal of Health Science.2021;13(5)

Theodoridis X, Grammatikopoulou M, Petalidou A, Kontonika S, Potamianos SP, Bogdanos DP A.Systematic Review of Medical Nutrition Therapy Guidelines for Liver Cirrhosis: Do We Agree?.Nutr Clin Pract.2020;35(1):98-107

Wu Y, Zhu Y, Feng Y.Royal Free Hospital-Nutritional Prioritizing Tool improves the prediction of malnutrition risk outcomes in liver cirrhosis patients compared with Nutritional Risk Screening. Br J Nutr. 2020;124(12):1293-1302.

Periyalwar P, Dasarathy S. Malnutrition in cirrhosis: contribution and consequences of sarcopenia on metabolic and clinical responses.Clin Liver Dis.2012;16(1):95-131

Georgiou A, Papatheodoridis GV, Alexopoulou A, Deutsch M, Vlachogiannakos I, Ioannidou P, etal. Evaluation of the effectiveness of eight screening tools in detecting risk of malnutrition in cirrhotic patients: the KIRRHOS study.Br J Nutr.2019;122(12):1368-1376.

Meyer F, Bannert K, Wiese M.Molecular Mechanism Contributing to Malnutrition and Sarcopenia in Patients with Liver Cirrhosis.Int J Mol Sci.2020;21(15):5357

Gu W, Hortlik H, Erasmus H, Schaaf L, Zeleke Y, Uschner F et al. Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018).Lancet. 2022;12,100240

GBD. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories,1990–2017:a systematic analysis for the Global Burden of Disease Study 2017.Cirrhosis Collaborators.lancet.2022;5(3):245-266.

Yoon JH, Jun CH, Kim JH, et al. Changing Trends in Liver Cirrhosis Etiology and Severity in Korea:the Increasing Impact of Alcohol.J Korean Med Sci. 2021;36(21):e145.

Mishra D, Dash KR, Khatua C. A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepatogastroenterol.2020;10(1):1-6

Rezaei N, Asadi-Lari M, Sheidaei A, Khademi S, Gohari K, Delavari F et al. Liver cirrhosis mortality at national and provincial levels in Iran between 1990 and 2015:A meta regression analysis.2019;PLoSONE 14(1):e0198449

Durazzo M, Belci P, Collo A.Gender specific medicine in liver diseases:a point of view.World J Gastroenterol.2014;20(9):2127-2135.

Sepanlou SG, Safiri S, Bisignano C.The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol.2020;5:245-266.

Younossi ZM, Koenig AB, Abdelatif D. Global epidemiology of nonalcoholic fatty liver disease: meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64:73-84.

Yılmaz Y, Kanı H, Demirtaş C,Kaya E,Sapmaz A, Qutranji L etal. Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience. Turk J Gastroenterol.2019;30(10):892-898.

Kaya E, Yılmaz Y. Non-alcoholic fatty liver disease: A growing public health problem in Turkey. Turk J Gastroenterol. 2019;30(10):865-871.

Cheemerla S, Balakrishnan M.Global Epidemiology of Chronic Liver Disease. Clinical Liver Disease.2021;17: 365-370

Alswat K, Aljumah AA, Sanai FM, Abaalkhail F, Alghamdi M, Al-Hamoudi W et al. Nonalcoholic fatty liver disease burden – Saudi Arabia and UAE,2017–2030.SaudiJ Gastroenterol.2018

Almahmoud MH,Al Khawaja NM, Alkinani A, Khader Y, Ajlouni KM. Prevalence of fatty liver disease and its associated factors among Jordanian patients with type2diabetes mellitus: A cross-sectional study. Ann Med Surg.2021;68:102677.

IDF.Diabetic Atlas,Iraqi Diabetic report.International diabetic federation,10thedition2021[website],updated2022.Available at https://www.diabetesatlas.org/data/en/country/96/iq.html(accessed12th,mar 2022)

Chapman B, Sinclair M, Gow PJ, Testro AG. Malnutrition in cirrhosis: More food for thought. World J Hepatol. 2020;12(11):883-896.

Johnson T, Overgard E, Cohen A, Dibaise J. Nutrition assessment and management in advanced liver disease. Nutrition in Clinical Practice.2013;28(1):15–29

Mishikawa H, Osaki Y. Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis. Basic and Clinical Advances in Chronic Liver Inflammation.2015

Maharshi S, Sharma B, Srivastava S.Malnutrition in cirrhosis increases morbidityandmortality.JGastroenterolHepatol.2015;30(10):1507-13.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Sharma P, Gupta C, Kumar A, Arora A, Anikhindi S, Singla V etal. Nutritional assessment and factors affecting dietary intake in patients with cirrhosis:A single-center observational study. Nutrition.2021;84:111099.