Pulmonary function tests in people with metabolic syndrome
A cross sectional observational study in a tertiary care hospital Telangana India
Keywords:
metabolic syndrome, forced expiratory volume, abdominal obesityAbstract
Background: Metabolic syndrome is a cluster of cardio- metabolic risk factors characterized by abdominal obesity, insulin resistance, and chronic systemic inflammation. Objectives: i)To assess pulmonary function in people with metabolic syndrome ii)To assess whether each component of metabolic syndrome affects pulmonary function indices. Methodology: After a detailed history and physical examination, subjects underwent investigations like fasting lipid profile, fasting blood sugars, electrocardiogram, chest x-ray, pulmonary function tests, 2D echocardiography. Results:In both groups majority had normal pulmonary function tests.In metabolic syndrome group, most common abnormal PFT reported was mild restriction.The pattern of pulmonary function tests is mild restriction in metabolic syndrome subjects.In the overall study group, hypertension, fasting glucose, body mass index, waist circumference have significant negative correlation with both FEv1 and FVC and triglycerides have significant negative correlation with FVC whereas total cholesterol has significant negative correlation with FEV1.Only HDL-c has strong positive correlation with FVC .Conclusion: The findings in this study highlight the notion that FVC and FEV1 are inversely associated with the accumulation of metabolic syndrome components and also independently associated with each component of metabolic syndrome.
Downloads
References
Adnani, H., Subiyanto, A., Hanim, D., & Sulaeman, E. S. (2018). Health promotion in clean and healthy behavior programs in traditional markets. International Research Journal of Management, IT and Social Sciences, 5(4), 46-52. https://doi.org/10.21744/irjmis.v5n4.251
Asanuma Y, Fujiya S, Ide H, Agishi Y. Characteristics of pulmonary function in patients with diabetes mellitus. Diabetes Res Clin Pract. 1985 Aug;1(2):95-101. doi: 10.1016/s0168-8227(85)80034-6. PMID: 3836101.
Bottai M, Pistelli F, di Pede F, et al. Longitudinal changes of body mass index, spirometry and diffusion in a general population. European Respiratory Journal. 2002;20(3):665–673.
Chen WL, Wang CC, Wu LW, Kao TW, Chan JY, Chen YJ, Yang YH, Chang YW, Peng TC. Relationship between lung function and metabolic syndrome. PLoS One. 2014 Oct 9;9(10):e108989. doi: 10.1371/journal.pone.0108989. PMID: 25299452; PMCID: PMC4191965.
Cirillo DJ, Agrawal Y, Cassano PA. Lipids and pulmonary function in the third national health and nutrition examination survey. The American Journal of Epidemiology. 2002;155(9):842–848.
Davis WA, Knuiman M, Kendall P, Grange V, Davis TM; Fremantle Diabetes Study. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Care. 2004 Mar;27(3):752-7. doi: 10.2337/diacare.27.3.752. PMID: 14988297.
Ehrlich SF, Quesenberry CP Jr, Van Den Eeden SK, Shan J, Ferrara A. Patients diagnosed with diabetes are at increased risk for asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and pneumonia but not lung cancer. Diabetes Care. 2010 Jan;33(1):55-60. doi: 10.2337/dc09-0880. Epub 2009 Oct 6. PMID: 19808918; PMCID: PMC2797986.
Fimognari FL, Pasqualetti P, Moro L, Franco A, Piccirillo G, Pastorelli R, Rossini PM, Incalzi RA. The association between metabolic syndrome and restrictive ventilatory dysfunction in older persons. J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):760-5. doi: 10.1093/gerona/62.7.760. PMID: 17634324.
Ford ES, ManninoDM. Prospective association between lung function and the incidence of diabetes: findings from the national health and nutrition examination survey epidemiologic follow-up study. Diabetes Care. 2004;27(12):2966–2970.
Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005 Oct 25. 112(17):2735-52.
Leone N, Courbon D, Thomas F, et al. Lung function impairment and metabolic syndrome the critical role of abdominal obesity. American Journal of Respiratory and Critical Care Medicine. 2009;179(6):509–516.
Lin WY, Yao CA, Wang HC, Huang KC. Impaired lung function is associated with obesity and metabolic syndrome in adults. Obesity (Silver Spring) 2006;14:1654– 1661.
Ljubić S, Metelko Z, Car N, Roglić G, Drazić Z. Reduction of diffusion capacity for carbon monoxide in diabetic patients. Chest. 1998 Oct;114(4):1033-5. doi: 10.1378/chest.114.4.1033. PMID: 9792573.
Meo SA, Al-Drees AM, Arif M, Al-Rubean K. Lung function in type 2 Saudi diabetic patients. Saudi Med J. 2006 Mar;27(3):338-43. PMID: 16532094.
Nakajima K, Kubouchi Y, Muneyuki T, Ebata M, Eguchi S, Munakata H. A possible association between suspected restrictive pattern as assessed by ordinary pulmonary function test and the metabolic syndrome. Chest. 2008 Oct;134(4):712-718. doi: 10.1378/chest.07-3003. Epub 2008 Jul 14. PMID: 18625672.
Ratnawati, I. G. A. A., Sutapa, G. N., & Ratini, N. N. (2018). The concentration of radon gas in air-conditioned indoor: Air quality can increase the potential of lung cancer. International Journal of Physical Sciences and Engineering, 2(2), 111–119. https://doi.org/10.29332/ijpse.v2n2.169
Rogliani P, Curradi G, Mura M, Lauro D, Federici M, Galli A, Saltini C, Cazzola M. Metabolic syndrome and risk of pulmonary involvement. Respir Med. 2010 Jan;104(1):47-51. doi: 10.1016/j.rmed.2009.08.009. Epub 2009 Oct 1. PMID: 19800211.
Selby JV, Friedman GD, Quesenberry CP., Jr. Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries. The American Journal of Epidemiology. 1990;131(6):1017–1027.
Shah, Swati H.; Sonawane, Pranali; Nahar, Pradeep; Vaidya, Savita; Salvi, Sundeep1. Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease. Lung India: Apr–Jun 2013 - Volume 30 - Issue 2 - p 108-112 doi: 10.4103/0970-2113.110417
Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest. 2005;127:1952–1959.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
van den Borst B, Gosker HR, Zeegers MP, Schols AM. Pulmonary function in diabetes: a metaanalysis. Chest. 2010 Aug;138(2):393-406. doi: 10.1378/chest.09-2622. Epub 2010 Mar 26. PMID: 20348195.
Weynand B, Jonckheere A, Frans A, Rahier J. Diabetes mellitus induces a thickening of the pulmonary basal lamina. Respiration. 1999;66(1):14-9. doi: 10.1159/000029331. PMID: 9973685.
Yeh HC, Punjabi NM, Wang NY, et al. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the atherosclerosis risk in communities (ARIC) study. Diabetes Care. 2008;31(4):741–746.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
