Study of infiltration patterns of lymphomas in bone marrow trephine biopsy and immunohistochemical analysis in a tertiary care institute
Keywords:
Lymphoma, Infiltration patterns, Bone marrow biopsy, ImmunohistochemistryAbstract
Lymphomas are malignant neoplasms of lymphoid cells present usually as solid mass in the lymphoid organs of the body. They have a tendency to metastasize to different parts of the body and bone marrow is one of the most frequent sites. They infiltrate particular parts of the bone marrow and hence form various different patterns of infiltration. Each lymphoma has its characteristic one or more patterns of infiltration. Recognition of such a pattern can often help in diagnosis of such lymphoma. This was a prospective descriptive study of one year duration enrolling known cases of lymphoma diagnosed in a tertiary care center and subsequently bone marrow trephine biopsy was done and studied for pattern of infiltration. Also immunohistochemistry was applied to differentiate B cell and T cell lymphomas. Paratrabecular pattern was the most common pattern seen solely or in mixed in the majority of the lymphoma cases. Also the frequencies of B cell lymphoma with CD-19 positivity were higher than T cell lymphoma with CD-3 positivity. Recognition of pattern of infiltration especially when no lymphomatous cells are identified on blood and or bone marrow aspiration smears are very helpful in diagnosis of lymphoma.
Downloads
References
Atac B, Lawrence C, Goldberg SN. Metastatic tumor: the complementary role of the marrow aspirate and biopsy. Am J Med Sci. 1991 Oct;302(4):211-3.
Barbara J, Bain David M, Clark Bridget S, Wilkins. Text book of Bone marrow pathology, fourth edition Bone Marrow Pathology, Fourth Edition 2010;4:30-99.
E J Lim, S C Peh. Bone Marrow and Peripheral Blood Changes in Non-Hodgkin’s Lymphoma. Singapore Med J 2000; 41(6): 279- 85.
Fend F, Kremer M. Diagnosis and Classification of Malignant Lymphoma and Related Entities in the Bone Marrow Trephine Biopsy. Pathobiology 2007;74:133–143.
Ishtiaq J, Jehanzeb K, Ali N, Alam M. Bone marrow infiltration and patterns in previously diagnosed patients of non hodgkin lymphoma (a single centre study). Pak Armed Forces Med J 2017; 67 (2): 249-52.
Jaffe E. S, Harris N. L, Stein H, Isaacson P. G. Classification of lymphoid neoplasms: the microscope as a tool for disease discovery. Blood (2008) 112 (12): 4384–4399.
Juan Rosai, MD. Non Hodgkin Lymphoma (lymph node). Text book of Rosai and Ackerman's Surgical Pathology, 10th Edition Copyright © Elsevier, 2013,1917-99.
Kamaluddin. (2021). Government and Private Collaboration in Coping with Covid-19 in Sorong City. International Research Journal of Management, IT and Social Sciences, 8(5), 333-341. https://doi.org/10.21744/irjmis.v8n5.1907
Kumar S, Rau AR, Naik R, Kini H, Mathai AM, Pai MR, Khadilkar UN. Bone marrow biopsy in non-Hodgkin lymphoma: a morphological study. Indian J Pathol Microbiol. 2009 Jul-Sep;52(3):332-8.
Kumar S, Rau AR, Naik R, Kini H, Mathai AM, Pai MR, Khadilkar UN. Bone marrow biopsy in non-Hodgkin lymphoma: A morphological study. Indian J Pathol Microbiol 2009;52:332-8.
Lee EJ, Kim M, Kim H, Kang HJ, Kim HJ, Min SK et al. CD3 and CD20 Immunohistochemical Staining Patterns of Bone Marrow-Infiltrating Malignant Lymphoma Cells. Ann Clin Lab Sci March-April 2017:47(2):136-143.
Park Y, Park BB, Jeong JY, Kim WY, Jang S, Shin BK, Lee DS, Han JH, Park CJ, Suh C, Kim I, Chi HS. Assessment of bone marrow involvement in patients with lymphoma: report on a consensus meeting of the Korean Society of Hematology Lymphoma Working Party. Korean J Intern Med. 2016 Nov;31(6):1030-1041.
Singh R, Shaik S, Negi BS, Rajguru JP, Patil PB, Parihar AS, Sharma U. Non-Hodgkin's lymphoma: A review. J Family Med Prim Care. 2020 Apr 30;9(4):1834-1840.
Sultan S, Baloch N, Ahmed ZA, Irfan SM, Parveen S. Pattern of bone marrow involvement in non Hodgkin's lymphoma classified according to WHO classification: Report of a developing country Pakistan. J Lab Physicians. 2018 Jan-Mar;10(1):17-20.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Exp Hematol Oncol. 2012 Nov 29;1(1):36.
Wirawan, I. G. B. (2018). Surya Namaskara benefits for physical health. International Journal of Social Sciences and Humanities, 2(1), 43–55. https://doi.org/10.29332/ijssh.v2n1.78
Zhang QY, Foucar K. Bone marrow involvement by hodgkin and non-hodgkin lymphomas. Hematol Oncol Clin North Am. 2009;23:873–902.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
