Histomorphorlogical and biochemical evaluation of oral administration of datura metel stramonium on the kidneys of adult male wistar rats
Keywords:
datura metel stramonium, nephrotoxicity, wistar ratsAbstract
Datura metel stramonium (leaves) extract has traditionally been used to treat swellings, burns, ulcers, asthma and sinus infections. However, report indicate that this plant is a strong poison and has been linked to delirium and acute poisoning, which may result in death. Aim: Histomorphological potentials and biochemical effects of Datura metel stramonium on the kidneys of adult male Wistar rats. Fresh Datura metel leaves were harvested, cleaned, air-dried and crushed into fine powder and cold macerated in 0.5 L of 80% v/v methanol in water for 72 hours and the resultant mixture was filtered using Whatman filter paper (No.1). The filtrate was condensed to dryness in vapour at 400C using water bath, yielding 9g (18% w/w) of a semi-solid extract and stored in the refrigerator at 40C until use. Twenty-four (24) adult male Wistar rats were divided into four (4) groups of six (6) animals each. Groups 1 (0.2ml of distilled water), 2 (200 mg/kg), 3 (400 mg/kg), and 4 (600 mg/kg) body weight/day had oral administration for twenty-eight (28) days. The Wistar rats were sacrificed by cervical dislocation and kidney tissues were excised for histomorphological and biochemical examinations.
Downloads
References
Abubakar, M., Suleiman, U., Frank, A., Ukwuani, A. (2009). Hallucinogenic Effects of aqueous seeds extract of Datural metel in Rats. The international journal of Myrmecology. 9 (1):
Adeniyi Y. Tijani, Ugbabe G. Eyineyi, Jemilat A. Ibrahim, Samuel E. Okhale (2015). Neuro-toxicological impacts of Datura Metel Linn. (Family: Solanaceae) leaves extract in mice. The Journal of Neurobehavioral Sciences, 2(3):1-5.
Allard, T., Wenner, T., Greten, HJ., Efferth, T. (2013). Mechanisms of herb-induced nephrotoxicity. Curr Med Chem. 20(22): 2812–2819.
Amaya, N. L. R., Cobeña, L. S. A., Gualpa, T. L. A., Ochoa, A. D. F., & Suarez, C. B. F. (2022). Manufacture of humus from plant residues. International Journal of Life Sciences, 6(1), 10–18. https://doi.org/10.53730/ijls.v6n1.4739
Aminoff D. (1961). Methods for the qualitative estimation of N-acetylneuraminic acid and their application to hydrolysis of sialomucoids. Biochem. J., 81: 384-392.
Anozie VC (1986). Pharmacognostic studies on Datura metel Linn. Macro- morphology and micro-morphology of fruits and seed: Herba Polonica 32(3/4): 197 – 208.
Asif M. (2012). A brief study of toxic effects of some medicinal herbs on kidney. Advanced biomedical research, 1, 44.
Aslam M (1996). Asian medicine and its practice in Britain. In: Trease and Evans Pharmacognosy. W.C. Evans (ed), 14th edition published by by W.B. Saunders Company Ltd. pp. 491-502.
Bauer, J and Osborn, H.M.L. (2015). Further medicinal chemistry, 7(16): 2285-2299.
Binev, R., Valchev, I., Nikolov, J. (2006) Clinical and pathological studies of Jimson weed (Datura stramonium) poisoning in horses. Trakia J Sci 4: 56-63.
Chinedu Imo, Kayode A. Arowora, Chukwuma S. Ezeonu, Ojochenemi E. Yakubu, Chukwumaobim D. Nwokwu, Nkiruka C. Azubuike, Yumanang G. Sallah (2019). Effects of ethanolic extracts of leaf, seed and fruit of Datura metel L. on kidney function of male albino rats. Journal of Traditional and Complementary Medicine 9 (2019) 271-277.
Chukwuma Chika feanyi, Motlalepula G. Matsabisa, Mohammed Auwal Ibrahim, Ochuko L. Erukainure, Matimbha H. Chabalala, Md. Shahidul Islam. (2019): Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. Journal of Ethnopharmacology, Volume 235, 10 May 2019, Pages 329-360.
Damilare, A., Adekomi, A.A., Tijani, O.K., Ghazal, O.K. (2010). Some effects of the aqueous leaf extract of Datura metel on the frontal contex of adult wistar rats (Rathus Norvegicus). European Journal of Anatomy. 14 (2): 83 – 89.
Das S, Kumar P, Basu SP. (2012). Review article on phytoconstituents and therapeutic potentials of Datura stramonium linn. J Drug Del Therap. 2(3):4–7.
Devi MR, Meenakshi B, Paul SB, Sharma GD (2011). Neurotoxic and medicinal properties of Datura stramonium L.-Review. Biol Envir Sci. 7(1):139–144.
Dubey, PK. and Sanjeev, OP (2017). Acute Renal Failure: A Complication of Datura Poisoning. J Kidney 3: (147): 1-2.
Foote, J and Cohen, B. (1998). Medicinal herb use and the renal patient. J. Renal Nutr. 8:40–42.
Gidado, A., Zainab, AA., Hadiza, MU., Serah, DP., Anas, HY. (2007) Toxicity studies of ethanol extract of the leaves of Datura stramonium in rats. African J Biotech 6: 1012-1015.
Iju, W. J., Emeka, O. A., Chukwuebuka, N. B., Richard, O. N., & Chidimma, O. (2022). Histomorphorlogical and biochemical evaluation of oral administration of datura metel stramonium on the kidneys of adult male wistar rats. International Journal of Health Sciences, 6(S7), 2948–2962. https://doi.org/10.53730/ijhs.v6nS7.12304
Kermi VA (2000). The vaults of Erowid: www.erowid.com Assessed on 01/23/2009. Archive date 12/02/2008.
Kirtikar JD, Basu BD. (1994). Indian medicinal plants. Allahabad: Lalit Mohan Basu; 1994: 1229–1231.
Lans CA. (2006). Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J Ethnobiol Ethno med. 2:45.
Lorke D (1983). A new approach to practical acute toxicity testing. Archieves Toxicol., 54: 275-287.
Nudrat Fatima and Naira Nayeem (2016). Toxic Effects as a Result of Herbal Medicine Intake. Open Access Peer Review Chapter 9. DOI: 10.5772/64468.
Oladosu, LA. and Case, AA. (1979). Large animal hepatotoxic and nephrotoxic plants. Vet Hum Toxicol 21: 363-365.
Oseni OA, Olarinoye CO, Amoo IA. (2011). Studies on chemical compositions and functional properties of thorn apple (Datura stramonium L) Solanaceae. Afric J Food Sci. 5(2):40–44.
Parashuram M. (2011). Isolation of 11,12,13,17-Tetrahydroxy-(Hydroxymethyl)-10-Nitrodotriacontahydrospiro[Indeno[5,6-A]Hexacene-2,2′-Pyran]=3,6(1H,18bh) Dione and its spectroscopic characterization and biological activities of bimetals from seeds of Datura stramonium. Asian J Bioch Pharm Res. 3(1):501–506.
Peter P. Ilinov, Denislava D. Deleva, Emilia T. Zaprianova and Svetoslav I. Dimov (1994) A Method for Determination of Lipid-Bound Sialic Acid After Chromatographic Isolation of Brain Gangliosides, Journal of Liquid Chromatography, 17:13, 2871-2879
Priyanka Soni, Anees Ahmad Siddiqui, Jaya Dwivedi and Vishal Soni (2012). Pharmacological properties of Datura stramonium L. as a potential medicinal tree: An overview. Asian Pac J Trop Biomed. 2(12):1002-1008.
Samraj, AN., Lläubli, H., Varki, N. and Varki, A. (2014). Involvement of a non-human sialic acid in human cancer. Front. Oncol. 19 (4) 33.
Sembulingam K., Sembulingam P. (2012): Essentials of medical physiology
Shagal MH, Modibbo UU, Liman AB. (2012). Pharmacological justification for the ethnomedical use of Datura stramonium stem-bark extract in treatment of diseases caused by some pathogenic bacteria. Int Res Pharm Pharmaco. 2(1):16–19.
Stencel-Baerenwald, J.E., Reiss, K., Reiter, D.M., Stehle, T., Dermody, T.S. (2014).The sweet spot: defining virus–sialic acid interactions. Nat Rev Microbiol 12, 739–749.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Tijani, Y.A., Eyineyi, U.G., Ibrahim, J.A., and Okhale, S.E. (2015). Neuro-Toxicological Impacts Of Datura metel Linn. (Family: Solanaceae) Leaves Extract In Mice, The Journal Of Neurobehavioral Sciences, 2(3): 1-5.
Trease GE, Evans WC (1996). Phytochemisrty of plants. In: Pharmacognosy. 14 th Edition. Alden Press. Oxford. pp. 213-232.
Wannang, N.N., Ndukwe, H.C. and Nnabuife, C. (2009). Evaluation of the analgesic properties of the Datura metel seeds aqueous extract. Journal of Medicinal Plants Research 3(4):192-195.
Wei, L., Chen, B., Ye, R., Li, H. (1999). Treatment of complications due to peritoneal dialysis for chronic renal failure with traditional Chinese medicine. J Tradit Chin Med. 19:3–9.
WHO (World Health Organization) (2003). Traditional medicine, media centre. www.whoint/mediacenter/factsheets/f5134/en/22k. Fact sheet N o 134 Revised December 2008; assessed on 01/19/2009. WHO (World Health Organization) (2004). Essential drugs and medicine policy.edm webadmin@who.int. 8:1-6; assessed on 01/19/2009.
William, L., Mary, M., Richard, AH. (2000). Lippincott’s Illustrated Reviews Pharmacology, second edition, pp.133-138.
Xiaoman Zhou, Ganglong Yang, and Feng Guan (2020). Biological functions and analytical strategies of Sialic Acids in tumor. Cells. 9(273): 1-18.
Zhang, C., Chen, J., Liu, Y. (2019). Sialic acid metabolism as a potential therapeutic target of atherosclerosis. Lipids Health Dis 18 (1)173.
Zhang, DN. (1989). Treatment of chronic renal failure with ‘serial recipes for renal failure’: A report of 64 cases. J Tradit Chin Med. 9:159–162.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
