Pulmonary function in patient with ulcerative colitis: A cross-sectional study from North India

Sunita Grover; Pratibha Maan; Shankar Lal Jat

doi:10.53730/ijhs.v6nS9.12693

Authors

Sunita Grover Assistant Professor, Department of Respiratory Medicine, Al Falah School of Medical Science and Research Center Dhauj , Faridabad (Haryana ), India
Pratibha Maan Assistant professor, Department of Pathology, SMS Medical College and attached hospitals, Jaipur, Rajasthan, India
Shankar Lal Jat
drshankar02@gamil.com
Associate Professor, Department of Gastroenterology, National Institute of Medical Science and Research, Jaipur, Rajasthan, India

Keywords:

Ulcerative colitis, pulmonary function, inflammatory bowel disease, obstructive lung disease, functional residual capacity

Abstract

Aim: To determine the type and frequency of pulmonary involvement in patients with UC and to determine the distribution of pulmonary dysfunction in patients with UC. Methods: A total of 39 cases of UC, were enrolled consecutively in this study from the Department of Gastroenterology. The age, sex, family history, duration of disease, biochemical parameters (CRP, ESR, blood routine test, etc.), lung function, chest X-ray, diagnoses, and treatments were collected. Patients and controls underwent standard pulmonary function testing. Comparisons of rates among multiple groups were done with Fisher exact test, continuous variables were compared with one-way ANOVA. Results: According to the true love index, the severity of active UC was moderate and severe among 36.7% and 63.3% of subjects respectively. The pulmonary function test “FCV” showed reduced mean FCV among subjects with active UC (2.86±0.77 litres) and inactive UC (3.91±0.62 litres) as compared to controls (4.04±1.14 litres). Among the patients with deranged PFT, 1 (7.6%) had obstructive, 7 (53.8%) had small airway disease and 5 (38.6%) had a restrictive pattern of lung involvement. Conclusion: Subclinical pulmonary dysfunction is frequent in UC and dependent on disease activity. Some alterations were sub-clinical and some of the patients showed troublesome pulmonary symptoms.

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