Evaluation of anti-hyperlipidemic activity of Euphorbia Hirta bark against triton ® WR 1339 induced hyperlipidemia

Prasanna Shama Khandige; Zeena Fernandes; Prashant Nayak; S Shubhangi; Prashant Singh

doi:10.53730/ijhs.v6nS8.12759

Authors

Prasanna Shama Khandige
prasannasham@nitte.edu.in
Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be university), Paneer, Deralakatte, Mangaluru. Karnataka, India-575018
Zeena Fernandes Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be university), Paneer, Deralakatte, Mangaluru. Karnataka, India-575018
Prashant Nayak Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be university), Paneer, Deralakatte, Mangaluru. Karnataka, India-575018
Shubhangi S Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be university), Paneer, Deralakatte, Mangaluru. Karnataka, India-575018
Prashant Singh Department of Pharmaceutics, Buddha Institute of Pharmacy, GIDA, Gorakhpur, (U.P.), India-273209

Keywords:

euphorbia hirtabark, Triton ®, hyperlipidemia, simvastatin

Abstract

Hyperlipidemia is the major risk factor causing many cardiovascular disorders like myocardial infarction and stroke, atherosclerosis. The world has complimented many herbal substances of therapeutic importance. There are many reports about the use of herbal medicine for reduction of lipid profile and reducing the cardiovascular risk in clinical subjects and experimental pharmacology. The plant Euphorbia hirta bark was evaluated for anti-hyperlipidemic activity by Triton (Superinone, Triton WR-1339), induced hyperlipidemia in rats. This study was carried out on the action of Euphorbia hirtabarkethanolic extracts, a known anti-hyperlipidemic drug, Simvostatin (10 mg/kg body wt.), was taken as a standard drug. The statistical parameters of mean± S.E were employed for the calculation of one way analysis of variance test (ANOVA) and Dunnet’s test for many comparison’s P < 0.05 were considered as significant. The studies were shown. There was a significant (P<0.01) reduction in serum levels in lipid profile experiments. It has reported a significant lower total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and an increase in high density lipoprotein (HDL).The study confirmed that ethanolic extract of Euphorbia hirta bark having significant anti-hyperlipidemic action proving a potential herbal medicine as an alternative to currenttreatment of hyperlipidemia.

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