Synthesis, characterization, and some pharmacological evaluation of 5-Thiocyanatouracil compound

Hussein Falih Neamah; Nadheerah F. Neamah; Shaker A. N. Al-Jadaan

doi:10.53730/ijhs.v6nS9.12830

Authors

Hussein Falih Neamah Criminal Lab. Manger / Forensic Dep in Basra police directorate. MOI MSc. Chemistry
Nadheerah F. Neamah Pharmacology &Toxicology Department, College of Pharmacy, University of Basrah, Iraq.
Shaker A. N. Al-Jadaan Pharmaceutical Chemistry Department, College of Pharmacy, University of Basrah, Iraq.

Keywords:

5-Iodouracil, Thiocyanato uracil, Potassium thiocyanate, DPPH, antibacterial, LD50

Abstract

5-Thiocyanotouracil (5-TCU) was prepared in convenient method involved direct reaction of Potassium thiocyanate with 5-Iodouracil in refluxing aqueous solvent to give white crystalline in very good yield and high purity. This compound is important because it is similar in structure to 5-Flourouracil, which is of great importance as anti-cancer drug that is still used today. FT-IR, 1H- NMR, 13C- NMR, and CHN elemental analyses were used to describe the product. Median lethal dose LD50, in vitro antiradical activity and antibacterial effects were done. The results indicated that 5-TCU has relatively high LD50, non-significate antioxidant effect compare with ascorbic acid, and some antibacterial activity.

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