Spinal induced hypotension in pre-eclamptic and healthy parturients: A randomized comparative clinical study

Tuhin Vashishth; Sangeeta Varun; Anil Kumar Gupta; Nitin Tiwari; Aman Kumar

doi:10.53730/ijhs.v6nS8.12838

Authors

Tuhin Vashishth Professor and Head, Department of Anaesthesia, ASMC, Firozabad (Uttar Pradesh)
Sangeeta Varun Associate Professor, Department of Anesthesia, LLRM Medical College, Meerut (Uttar Pradesh)
Anil Kumar Gupta Assistant Professor, Department of Anaesthesia, ASMC, Firozabad (Uttar Pradesh)
Nitin Tiwari
doctor4unitin@gmail.com
Assistant Professor, Department of Community Medicine, ASMC, Firozabad (Uttar Pradesh)
Aman Kumar Assistant Professor, Department of Community Medicine, Saraswati Medical College & Hospital, Unnao (Uttar Pradesh)

Keywords:

spinal induced hypotension, preeclamptic parturient, healthy parturient

Abstract

Background: Preeclampsia/eclampsia is the third leading cause of maternal morbidity and mortality. This study aimed to evaluate the incidence and severity of spinal-induced hypotension in preeclamptic and healthy parturients. Material & Methods: A total of 60 pregnant patients undergoing a C-Section with spinal anesthesia were randomly allocated into two groups. Group I: Preeclamptic 0.5%, 2.5cc (12.5mg) Hyperbaric Bupivacaine group: 30 patients. Group II: Normotensive 0.5%, 2.5cc (12.5mg) Hyperbaric Bupivacaine group: 30 patients. The blood pressure values were recorded before spinal anesthesia and 2.5 minutes after a spinal puncture. Results: The mean age of the study group was 25.17+3.61 years (Mean +S.D.) and range is 18-30Years. The BP falls from baseline were significantly greater in the healthy parturients compared to those with preeclampsia (25.8% ± 10.1 vs 18.8% ± 17.0 for SBP, 28.5% ± 8.8 vs 22.5% ± 10.4 for DBP, and 31.2% ± 14.2 vs 18.2% ± 12.6% for MAP, p < 0.05). The incidence rate of hypotension in preeclamptic was 53% compared to 25% in healthy parturients (p < 0.001). Conclusion: The incidence of spinal-induced hypotension associated with patients undergoing C-Section is more in preeclamptic than in healthy parturients.

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