Screening of catharanthus roseus stem extract for anti-ulcer potential in wistar rat
Keywords:
Catharanthus roseus, Stem extract, anti-ulcer effect, pharmacological actions, gastric ulcer modelAbstract
This study aims to evaluate the anti-ulcer effect of Catharanthus roseus Stem extract on gastric ulcers caused by forced swimming. It was investigated that Catharanthus roseus having many kinds of phytochemical constituents so it is responsible for different pharmacological actions. The ethanolic extract of Catharanthus roseus stem at 250 and 500 mg/kg orally (PO) significantly reduces the incidence of ulcers. In this investigation albino wistar rats induced by forced swimming, an increase in the rate of ulcers was observed compared to the control group. The ethanol extract of Catharanthus roseus stem showed a significant decrease in the previous index at a dose of 500 mg/kg; it was comparable to the standard preparation ranitidine (5 mg/kg). The protection index of Catharanthus roseus stem extract was 65.4%, while the protection index of the standard preparation ranitidine was 76.8%.
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Ajaib M, Khan ZUD, Khan N, Wahab M. Ethnobotanical studies on useful shrubs of District Kotli, Azad Jammu & Kashmir, Pakistan. Pak J Bot. 2010; 42:1407-1415.
Dr. Hemamalini Balaji, Versatile. Therapeutic effects of Vinca rosea Linn. International Journal of Pharmaceutical Science and Health Care. 2014; 1(4):59-76.
Erdogrul. Antibacterial activities of some plant extract used in folk medicine. Pharm. Biol. 2002; 40:269-273.
Bennouna J, Delord JP, Campone M, Nguyen L. Vinflunine. A new microtubule inhibitor agent. Clin Cancer Res. 2008; 14:1625-32.
Banskota AH. Antiproliferative activity of Vietnamese medicinal plants. Biological Pharmaceutical Bulletin. 2002; 25(6):753-60.
Hejaz HA, Karaman R. Drug overview. COMMONLY USED DRUGS-USES, SIDE EFFECTS, BIOAVAILABILITY AND APPROACHES TO IMPROVE IT. 2015:1.
Ravina E. The evolution of drug discovery: from traditional medicines to modern drugs. John Wiley & Sons; 2011 Apr 18.
Mondal A, Gandhi A, Fimognari C, Atanasov AG, Bishayee A. Alkaloids for cancer prevention and therapy: Current progress and future perspectives. European journal of pharmacology. 2019 Sep 5;858:172472.
Leeuwenberg AJ. Voacanga Thou. InSeries of revisions of Apocynaceae 1985 (Vol. 15, No. 85.3, pp. 5-80).
Banskota AH. Antiproliferative activity of Vietnamese medicinal plants. Biological Pharmaceutical Bulletin. 2002; 25(6):753-60.
6. Wang S, Zheng Z, Weng Y. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Science. 2004; 74(20):2467-78.
Chattopadhyay RR, Sarkar SK, Ganguli S. Hypoglycemic and antihyperglycemic effect of leaves of Vinca rosea Linn. Indian Journal of Physiology and Pharmacology. 1991; 35:145-51.
Singh SN, Vats P, Suri S. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. Journal of Ethnopharmacology. 2001; 76:269-77.
Chattopadhyay RR. A comparative evaluation of some blood sugar lowering agents of plant origin. Journal of Ethnopharmacology. 1994; 67:367-72.
Prajakta Patil J, Jai S. Ghosh. Antimicrobial Activity of Catharanthus roseus – A Detailed Study. British Journal of Pharmacology and Toxicology. 2010; 1(1):40-44.
Alba Bhutkar MA, Bhise SB. Comparative Studies on Antioxidant Properties of Catharanthus Rosea and Catharanthus. International Journal of Pharmaceutical Techniques. 2011; 3(3):1551-1556.
Swati Agarwal, Simi Jacob, Nikkita Chettri, Saloni Bisoyi, Ayesha Tazeen, Vedamurthy AB et al. Evaluation of In-vitro Anthelminthic Activity of Catharanthus roseus Extract. International Journal of Pharmaceutical Sciences and Drug Research. 2011; 3(3):211-213.
Babulova A, Machova J, Nosalova V. Protective action of vinpocetine against experimentally induced gastric damage in rats. Arzneimittel forschung. 2003; 43:981-985.
Pillay PP, Nair CPM, Santi Kumari TN. Lochnera rosea as a potential source of hypotensive and other remedies. Bulletin of Research Institute of the University of Kerala. 1959; 1:51-54.
Mithun Singh Rajput, Veena Nair, Akansha Chauhan. Evaluation of Antidiarrheal Activity of Aerial Parts of Vinca major in Experimental Animals. Middle-East Journal of Scientific Research. 2011; 7(5):784-788.
Nayak BS, Anderson M, Pereira LMP. Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats. Fitoterapia. 2007; 78:540-544.
Patel Y, Vadgama V, Baxi S, Tripathi CB. Evaluation of hypolipidemic activity of leaf juice of Catharanthus roseus (Linn.) G. Donn. in guinea pigs. Acta Pol Pharm. 2011 Nov 1;68(6):927-35.
Sekar P. Vedic clues to memory enhancer. The Hindu, March. 1996;21.
Rahul A. , Wandrel ., Gajanan B. Bhagwati , Rahul S. Solunkel , Mayuri B. Yadavi , Shaikh A. M. , A review on mrdicinal plants with Anti -ulcer activity , J. of pharmacognosy and phytochemistry , Vol.2 No. 1, 2013.
Maury kumar Pradip, Jain S.K. , Nand Lal and Shashi Alok , Review on antiulcer activity ,JPSR ,2012, Vol.3(8) : 2457-2493.
Hoogerwerf WA, Pasricha PJ. Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. The pharmacological basis of therapeutics. 2001:1005-19.
Kaur Amandeep , Singh Robin , Sharma Ramica , Kumar Sunil , peptic ulcers : A Review on etiology and pathogenesis , INT Journal of research pharmacy : vol. 3(6) , 2012 , 2230-8407.
Copyright 2001-2013|| all right reserved 600 north Wolfe street , Baltimore ,Maryland 21287.
R. K. Goyal, Elements of Pharmacology, B.S. Shah Prakashan, New Delhi, India, 17th edition, 2008.
G. Vincent, G. Glavine, J. Rutkowski, and W. Pare, “Body orientation, food deprivation and potentiation of restraint induced gastric lesions,” Gastroenterology Clinique et Biologique, vol. 1, no. 6-7, pp. 539–543, 1977.
Garrigues -Gil, V., 1988. Antacids in the treatments of peptic ulcers disease. methods and finding in experimental and clinical pharmacology ,11, p.p. 77.
Rahul A., Wandre, Gajanan B. Bhagwati, Rahul S. Solunke, Mayuri B. Yadav, shaikh A. M., A review on medicinal plants with Anti – ulcers activity, journal of pharmacognosy and phytochemistry, vol.2(1), 2013,235.
Padmashree Dr. D.Y. Patil, clinical study of peptic ulcer disease, Asian journal of biomedical and pharmaceutical science, 6(53), 2016, 41-43.
Shaikh sabir, Shete Anmol, Doijad Rajendra, formulation and evaluation pharmaceutical aqueous gel of powdered guava leaves for mouth ulcer treatment, PharmaTutor, 6(4), 32-38, 2018.
B.V.S. Lakshmi, Sudhakar, Md. Imtiyaz, evaluation of antiulcer activity of the aqueous extract of piper nigrum and ferula foetida, international journal of pharma research and review 3(4), 43-49, April 2014.
Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences; 2014 Aug 27.
Maurya Kumar Pradip, Jain S.K. , Nand Lal and Alok Shashi , A Review on anti-ulcer activity, international journal and pharmaceutical science and research ,vol3(8), 2487-2493,2012.
We Papers. (2020, December, 11) Peptic Ulcer Disease Research Paper Samples. Retrieved March 12, 2021, from https://www.wepapers.com/samples/peptic-ulcer-disease-research-paper-samples/.
Cohen, S. (2007). Peptic Ulcer Disease. Retrieved December 25, 2009, from http://www.merck.com/mmpe/sec02/ch013/ch013e.html.
Stratemeier M. Peptic ulcers. Retrieved November 28, 2009. from http://www.emedicinehealth.com/peptic ulcer/article em.htm.
The American college of Gastroenterology. 2009. peptic ulcer disease . Retrieved 30 November, 2009, from http://www.gi.org/patients/gihealth/peptic.asp.
Shayne P. and Miller W. (2009) . Gastritis and peptic ulcer disease . Retrieved ,25 December 2009 , from http://emedicine.medscape.com/article/776460 overview.
Wolfgang Fischbach, peter Malfertheiner , Jorg C. Hoffmann etal. Clinical practice guideline : Helicobacter Pylori and gastroduodenal ulcer disease . Deutsches Arzteblatt international journal ,106(49): 801-8, 2009 December,2009.
Garrigue -Gill , V. Antacid in the treatment of peptic ulcer disease . methods and findings in experimental and clinical pharmacology ,11 pp.77, 1998.
Sethi Saurabh, Kiara, medically reviewed, 25 June ,2018. https://www.healthline.com/.
To cure genital ulcer, the doctor performs an anti-viral order antibiotic which reduces the infection.
Mahathi K, Ramya MG, Samifar SK, Sindhuri TK, Madhuri K. Evaluation of anti-ulcer activity of methanolic extract of Leaves of Catharanthus roseus in experimental rats. Der Pharmacia Lettre. 2013;5(6):43-7.
Rambhai PA, Sisodia SS, Chaudhuri A, Patidar A. Antiulcer and Antihyperlipidaemic Efficacy of Catharanthus roseus Leaves on pylorus ligation induced Ulcer in Experimental Animals. Pharmaceutical and Biosciences Journal. 2019 Jul 9:07-12.
Mekonnen AN, Asrade Atnafie S, Wahab Atta MA. Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del.(Euphorbiaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine. 2020 Apr 9;2020.
Jai Narayan Mishra, Navneet Kumar Verma, A brief study on Catharanthus Roseus: A review, International Journal of Research in Pharmacy and Pharmaceutical Sciences, ISSN: 2455-698X; Volume 2; Issue 2; March 2017; Page No. 20-23
Rao SP, Amrit I, Singh V, Jain P. Antiulcer activity of natural compounds: A review. Research Journal of Pharmacognosy and Phytochemistry. 2015 Apr 1;7(2):124.
Aruna MS, Prabha MS, Priya NS, Nadendla R. Catharanthus Roseus: ornamental plant is now medicinal boutique. Journal of Drug Delivery and therapeutics. 2015 Oct 2:1-4.
Vutukuri VR, Das MC, Reddy M, Prabodh S, Sunethri P. Evaluation of acute oral toxicity of ethanol leaves extract of Catharanthus roseus in Wistar albino rats. Journal of clinical and diagnostic research: JCDR. 2017 Mar;11(3):FF01.
Kabubii ZN, Mbaria JM, Mbaabu M. Acute toxicity studies of Catharanthus roseus aqueous extract in male Wistar rats. African Journal of Pharmacology and Therapeutics. 2015 Oct 27;4(4).
Ajuru MG, Ajuru G, Nmom FW, Worlu CW, Igoma PG. Acute toxicity study and determination of median lethal dose of Catharanthus roseus in Wistar Albino rats. Journal of Applied Sciences. 2019 Mar;19(3):217-22.
Rani J, Kapoor M, Kaur R. In-vitro anti-bacterial activity and phytochemical screening of crude extracts of Catharanthus roseus L.(G.) Don. Agricultural Science Digest. 2017 Jun 1;37(2):106-11.
Goyal P, Khanna A, Chauhan A, Chauhan G, Kaushik P. In vitro evaluation of crude extracts of Catharanthus roseus for potential antibacterial activity. International Journal of Green Pharmacy (IJGP). 2008;2(3).
Sain M, Sharma V. Catharanthus roseus (an anti-cancerous drug yielding plant)-a review of potential therapeutic properties. Int J Pure App Biosci. 2013;1(6):139-42.
Balaji DH. Versatile. Therapeutic effects of Vinca rosea Linn. International journal of pharmaceutical Science and Health Care. 2014;1(4):59-76.
Bennouna J, Delord JP, Campone M, Nguyen L. Vinflunine: a new microtubule inhibitor agent. Clinical cancer research. 2008 Mar 15;14(6):1625-32.
Pulok K. Mukherjee, Quality control of Herbal Drugs- An approach to evaluation of Botanicals, New Delhi: Business Horizons, 2008.
Madhavan V, Hema Basnett, Gurudeva MR, Yogonarasimhan SN, Pharmacognostical evaluation of Drosera BurmanniiVahl(Droseraceae). Indian journal of traditional knowledge, 8 (3), 2009, 326-333.
Susmit K and Archana T (2011). Viewing anti-diabetic assets and analysis of stevioside from Stevia rebaudiana crude extract in STZinduced diabetic BALB/CAN. N (IB) mice. J. Pharm. Res., 112-117.
Kokate CK, Purohit AP and Gokhale SB (2001). Carbohydrate and derived Products, drugs containing glycosides, drugs containing tannins, lipids and protein alkaloids. Text book of Pharmacognosy, 7th ed. India: Nitrali Prakashan.
Singh S, Kaur R and Sharma SK (2013). Pharmacognostical standardization of the roots of Rumex hastatus D. Don. Asian. J. Pharm.Clin. Res., 126-128.
Kumar S, Malayaman V and Sindhuja S (2013). Phytochemical screening and antibacterial evaluation of the leaf, flower and seed coat extracts of Cassia alata L. J. Chem. Pharm. Res., 740-744.
Khandewal KR (2008). Practical Pharmacognocy. Nirali Prakashan, Pune, 19th ed edition.
Hema TA, Shiny M and Parvathy J (2012). Antimicrobial activity of leaves of Azima tetracantha against clinical pathogens. Int. J.Pharm. Sci., 317-319.
Ayoola GA, Coker HA, Adesegun SA, Adepoju-Bello AA, Obaweya K, Ezennia EC and Atangbayila TO (2008). Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in Southwestern Nigeria.Trop. J. Pharmaceul. Res., 1019-1024.
Kumar, S. (2022). A quest for sustainium (sustainability Premium): review of sustainable bonds. Academy of Accounting and Financial Studies Journal, Vol. 26, no.2, pp. 1-18
Allugunti V.R (2022). Breast cancer detection based on thermographic images using machine learning and deep learning algorithms. International Journal of Engineering in Computer Science 4(1), 49-56
Viswanatha KKRC, Reddy A, Elango N M (2019). Diabetes Kaggle Dataset Adequacy Scrutiny using Factor Exploration and Correlation, International Journal of Recent Technology and Engineering (IJRTE) Vol. 8.
Dubey M and Sushma (2014). Phytochemical status of some selected medicinal plants (Eclipta alba, Catharanthus roseus and Swertia chirata). Asian. J. Plant. Sci. and Res., 28-34.
Mir MA, Sawhney SS and Jassal MMS (2013). Qualitative and quantitative analysis of phytochemicals of Taraxacum officinale. Wudpecker. J. Pham. Phamacol., 1-5.
Ugochukwu SK, Uche A and Ifeanyi O (2013). Preliminary phytochemical screening of different solvent extracts of stem bark and roots of Dennetia tripetala G. Baker. Asian. J Plant. Sci and Res., 10-13.
Singleton VL and Rossi JA (1965). Colourimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J Enol. Vitic., 144-158.
Park YS, Jung ST, Kang SG, Heo BG, Arancibia-Avila P, Toledo F, Drzewiecki J, Namiesnik J and Gorinstein S (2008). Antioxidants and proteins in ethylene- treated kiwifruits. Food. Chem., 640-648.
Dapar, L.P.M., C.J. Aguiyi, N.N. Wannang, S.S. Gyang and M.N. Tanko, 2007. The histopathologic effects of Securidaca longepedunculata on heart, liver, kidney and lungs of rats. Afr. J. Biotechnol., 6: 591-595.
Rao CV, Sairam K, Goel RK. Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion. Indian Journal of Physiology and Pharmacology. 2000 Oct 24;44(4):435-41.
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