Screening of catharanthus roseus stem extract for anti-ulcer potential in wistar rat

Suraj Mandal; Sweta Goel; Monika Saxena; Polly Gupta; Jyoti Kumari; Prashant Kumar; Mukesh Kumar; Rahul Kumar; Km. Shiva

doi:10.53730/ijhs.v6nS9.12889

Authors

Suraj Mandal IIMT College of Medical Science, IIMT University, Meerut, India, 250001
Sweta Goel IIMT College of Medical Science, IIMT University, Meerut, India, 250001
Monika Saxena Steller Institute of Pharmacy, Bareilly, U.P.
Polly Gupta Lucknow Model College of Pharmacy, Lucknow, U.P.
Jyoti Kumari IIMT College of Medical Science, IIMT University, Meerut, India, 250001
Prashant Kumar Department of Pharmacy, M.J.P. Rohilkhand University, Bareilly, U.P. 243006
Mukesh Kumar Department of Pharmaceutics, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Subhartipuram Delhi-Haridwar Meerut Bypass Road, NH-58, Meerut, 250005
Rahul Kumar N.K.B.R. College of Pharmacy and Research Centre, Meerut – Hapur Road, Phaphunda, Meerut, 245206, Uttar Pradesh, India
Km. Shiva NGI College of Pharmacy, Near SVBP University, Modipuram, Meerut, U.P.

Keywords:

Catharanthus roseus, Stem extract, anti-ulcer effect, pharmacological actions, gastric ulcer model

Abstract

This study aims to evaluate the anti-ulcer effect of Catharanthus roseus Stem extract on gastric ulcers caused by forced swimming. It was investigated that Catharanthus roseus having many kinds of phytochemical constituents so it is responsible for different pharmacological actions. The ethanolic extract of Catharanthus roseus stem at 250 and 500 mg/kg orally (PO) significantly reduces the incidence of ulcers. In this investigation albino wistar rats induced by forced swimming, an increase in the rate of ulcers was observed compared to the control group. The ethanol extract of Catharanthus roseus stem showed a significant decrease in the previous index at a dose of 500 mg/kg; it was comparable to the standard preparation ranitidine (5 mg/kg). The protection index of Catharanthus roseus stem extract was 65.4%, while the protection index of the standard preparation ranitidine was 76.8%.

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