Helicobacter pylori infection and celiac disease in children, what is the relationship?
Keywords:
Celiac disease – H, pylori, Anti TTG Ig A, Endomysial AbAbstract
Background: Celiac disease (CD) is an autoimmune disease affecting the small intestine, triggered by gluten. The pathogenesis of CD has been well defined, and the increasing prevalence of this disease had led to studying several environmental risk factors that may trigger an autoimmune process in the small intestine. Infection is one of the most important factors that can trigger autoimmune processes. The researchers have studied the association between H. pylori infection and CD, the authors have reported conflicting results. Purpose: to study the association of H. pylori and celiac disease (CD) at the time of CD diagnosis in children. Patient and Methods: All patients in the study were subjected to full history taking, thorough clinical examination, and laboratory investigations including Anti-tissue transglutaminase antibodies (IgA), anti-endomysial (IgA EMA), Stool Ag for H. pylori, CLO test for H. pylori, Immunoglobulins level, Upper gastrointestinal endoscopy with multiple biopsies for histopathological examination. Results: Anti TTG Ig A and Endomysial Ab were positive in 49 patients, while one patient showed negative results. 7 patients (14%) had H.
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- Assa A, Frenkel-Nir Y, Tzur D, Katz LH, Shamir R. Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities. Acta Paediatr 2017; 106: 967-972.
- Nellikkal SS, Hafed Y, Larson JJ, Murray JA, Absah I. High Prevalence of Celiac Disease Among Screened First-Degree Relatives. Mayo Clin Proc 2019; 94: 1807-1813.
- Smyk DS, Koutsoumpas AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: cause or by stander. World J Gastroenterol 2014; 20: 613-29.
- Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth GS, Rewers M. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006; 101: 2333-2340.
- Thomas, H.J.; Ahmad, T.; Rajaguru, C.; Barnardo, M.; Warren, B.F.; Jewell, D.P. Contribution of histological, serological, and genetic factors to the clinical heterogeneity of adult-onset coeliac disease. Scand. J. Gastroenterol. 2009, 44, 1076–1083.
- Konturek PC, Karczewska E, Dieterich W, et al. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000; 95: 3682-3.
- Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth GS, Rewers M. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006; 101: 2333-2340.
- Sebahat Basyigit, Oktay Unsal, Metin Uzman, Ferdane Sapmaz , Ozlem Ceylan Dogan , Ayse Kefeli5 , Zeliha Asilturk, Abdullah Ozgur Yeniova, Yasar Nazligul. Relationship between Helicobacter pylori infection and celiac disease: a cross-sectional study and a brief review of the literature. Gastroenterology Review 2017; 12 (1).
- Benjamin Lebwohl, Martin J. Blaser, Jonas F. Ludvigsson, Peter H. R. Green, Andrew Rundle, Amnon Sonnenberg, and Robert M. Genta. Decreased Risk of Celiac Disease in Patients With Helicobacter pylori Colonization. Am J Epidemiol. 2013;178(12):1721–1730.
- Freeman HJ, Chopra A, Clandinin MT, Thomson AB. Recent advances in celiac disease. World J Gastroenterol 2011; 17: 2259-2272 [PMID: 21633592 DOI: 10.3748/wjg.v17.i18.2259.
- Volta U, Villanacci V. Celiac disease: diagnostic criteria in progress. Cell Mol Immunol 2011; 8: 96-102 PMID: 21278763 DOI: 10.1038/cmi.2010.64.
- Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabó IR, Sarnesto A, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998;115:1322–28.
- Steffen Husby, Sibylle Koletzko, Ilma Korponay-Szabo, Kalle Kurppa, jjM. Margreet Wessels Et al., European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. JPGN 2020,Volume 70, Number 1, 141-156.
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