Association of PDE8B gene polymorphisms with thyroid disorders
A meta-analysis and systematic review
Keywords:
Phosphodiesterase 8B, Single nucleotide polymorphism, Thyroid disease, Meta-analysis, Thyroid hormonesAbstract
Thyroid disorders are the most common endocrine disorders worldwide. PDE8B is strongly expressed in the thyroid and to a lower extent in the pituitary and hypothalamus. PDE8B gene affects the synthesis of T3 and T4 and regulates the release of TSH by the pituitary gland. Therefore, PDE8B single nucleotide polymorphisms (SNPs) rs 6885099 and rs2046045 play a crucial part in the incidence of thyroid disorders, but the existing data is insufficient and contradictory. Materials & Methods. Meta-analysis was carried out to assess the relationship between PDE8B SNP’s rs 6885099 and rs 2046045 and thyroid diseases. The present meta-analysis included 9 distinct studies from January 2005 to 2021 accessible at PubMed, Embase and Google scholar. The funnel plot was used to assess the publication bias. Meta Essentials 1.5 software was employed for statistical data analysis. Q test was used to calculate heterogeneity between the studies. The heterogeneity-related variation was calculated by I2. The association between PDE8B polymorphism and thyroid diseases was analysed by fixed and random effect models.
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