Cytokine profile associated with fungal infections in patients with otitis media
Keywords:
otitis media, ELISA, IFN-γAbstract
The current study includes a collection of (90) middle ear swabs samples from patients with middle ear infection who attended at the ENT unit at Al- Hilla Teaching Hospital and Imam Sadiq Hospital in Babylon city during the period from October 2021 to February 2022. The blood samples were collected from all patients as well as (40) apparently healthy control. The fungal isolates were identified according to cultural, biochemical tests, confirmed by VITEK 2 system compact. The results revealed that 15:90 were fungal positive culture. The most common fungal pathogen is Candida parapsilosis (10:15). Cytokine profile for patients revealed that IFN-γ and CTLA-4 increase in patients as compared to control versus IL-10 increases in control than patients.
Downloads
References
Abzug, M.J. and T.J. Walsh, Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children. The Pediatric infectious disease journal, 2004. 23(8): p. 769-773.
Ahn, J.J., et al., Experimental infection with Listeria monocytogenes as a model for studying host interferon-γ responses. JoVE (Journal of Visualized Experiments), 2016(117): p. e54554.
Arijit, D., A Study on Incidence and Types of Otomycosis in Patients Diagnosed with Chronic Suppurative Otitis Media. 2017, PSG Institute of Medical Sciences and Research, Coimbatore.
de Araújo, N.D., et al., Translating unconventional T cells and their roles in leukemia antitumor immunity. Journal of Immunology Research, 2021. 2021.
Dhanda, S.K., P. Vir, and G.P. Raghava, Designing of interferon-gamma inducing MHC class-II binders. Biology direct, 2013. 8(1): p. 1-15.
Dovedi, S.J., et al., Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T CellsModulated CTLA4 Inhibition via Preferential Binding to PD-1. Cancer Discovery, 2021. 11(5): p. 1100-1117.
Felce, J.H., et al., Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behavior within the T cell immunological synapse. Frontiers in cell and developmental biology, 2021. 8: p. 608484.
Juyal, D., et al., Significance of fungal flora in chronic suppurative otitis media. Annals of Tropical Medicine and Public Health, 2014. 7(2): p. 120.
Lecocq, Q., et al., The next-generation immune checkpoint LAG-3 and its therapeutic potential in oncology: Third time’sa charm. International Journal of Molecular Sciences, 2020. 22(1): p. 75.
Mpakali, A. and E. Stratikos, The role of antigen processing and presentation in cancer and the efficacy of immune checkpoint inhibitor immunotherapy. Cancers, 2021. 13(1): p. 134.
Pardoll, D., Cancer Immunotherapy with Vaccines and Checkpoint Blockade, in The Molecular Basis of Cancer: Fourth Edition. 2014, Elsevier Inc. p. 709-738. e8.
Ray, R., et al., Prevalence of fungal infection in chronic otitis media-A study at a tertiary care hospital in Eastern India. Int J Curr Microbiol App Sci, 2015. 4(3): p. 684-90.
Rye, M.S., J.M. Blackwell, and S.E. Jamieson, Genetic susceptibility to otitis media in childhood. The Laryngoscope, 2012. 122(3): p. 665-675.
Sabat, R., et al., Biology of interleukin-10. Cytokine & growth factor reviews, 2010. 21(5): p. 331-344.
Schneider, H. and C.E. Rudd, Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4. Frontiers in immunology, 2014. 5: p. 619.
Skotnicka, B. and E. Hassmann, Proinflammatory and immunoregulatory cytokines in the middle ear effusions. International journal of pediatric otorhinolaryngology, 2008. 72(1): p. 13-17.
Smirnova, M.G., et al., Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. European cytokine network, 2002. 13(2): p. 161-72.
Thorsen, S.U., et al., Maternal and cord blood 25-hydroxyvitamin D3 are associated with increased cord blood and naive and activated regulatory t cells: the barwon infant study. The Journal of Immunology, 2021. 206(4): p. 874-882.
Unsdgaard, J.V., et al., Deep metric learning for otitis media classification. Medical Image Analysis, 2021; 71:102034.
Vella, J.P. and A. Mehboob, The Immunobiology of Transplant Rejection and Acceptance, in Transplantation Surgery. 2021, Springer. p. 51-63.
Wu, J., et al., Local induction of bladder Th1 responses to combat urinary tract infections. Proceedings of the National Academy of Sciences, 2021. 118(10): p. e2026461118.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
