Evaluation of the DNA damage and the oxidative stress induced by occupational exposure at gas stations workers
Keywords:
gas station workers, heavy metals, DNA damage, comet assay, antioxidants, oxidative stressAbstract
The ambient of Gas stations includes several pollutants, like vehicle exhaust, particulate matter (PM2.5), and violate organic carbon (VOCs) products, occupational exposure to volatile organic carbon (VOCs) are the main components of fuel and vehicle exhaust on the DNA damage, antioxidants, and oxidative stress in addition level of the heavy metals in blood the study carry out in AL-Furat al-awsat consisting of 90 people participated in this study. included 60 workers have been exposed to pollutants of the Gas station and 30 healthy people as a comparison with those exposed. The aim of this study to estimate of the affect of vapor emitted directly from filling stations mainly containing with a lot of saturated and unsaturated hydrocarbon as well as heavy metals (HM) on antioxidants, level of oxidative stress, and DNA damage by shape and size tail length.The results showed decline in antioxidants (SOD), (CAT) at (p-value< 0.0001) and increased in value of (MDA) at (p_value< 0.0001), increased in levels of lead (Pb), cadmium (Cd) with a highly significant at (p_value <0.0001) and cobalt (Co) with a significant at (p_value <0.01) compared with non-exposed, there is significant increase in size of tail length compared with health at (p_value< 0.0001).
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