Green chemistry as efficient approache to achieve a new series of heterocyclic compounds
Keywords:
green chemistry, one-pot multicomponent reaction, grinding technique, microwave irradiation, imidazole, 1,2,4 triazoleAbstract
Solid phase one-pot Multicomponent reaction was used widely to achieved a board spectrum of heterocyclic compounds due to it’s supreme properties starting from four component mixture of piperonal binzil, p-phenylene diamine and ammonium acetate which was reacted directly through grinding then microwave irradiation at (270 watt) for (8 min) in a cidic media to afford 1-N(p-aminophenyl)-2-(piperonyl-5-yl)-5-hydroxy-4, 5-diphenyl-2H-imidazole (1) which then converted to its N'-aroyl derivatives (2-4) through it’s reaction with substituted benzoyl chloride in basic media terminated by direct reaction with acetic anhydride to obtained N'-acetyl-N'-aroyl derivative (5-7) followed by inter cyclization reaction with hydrazine hydrate (99%) to achieve 1,2,4-trizole derivatives (8-10) in basic media. The assigned structure of the prepared compounds were corroborated by the available physical and spectral methods.
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