Nanocomposite based drug delivery for periodontal disease
Keywords:
Periodontitis, Nanocomposite, CHX, PGS, nHAPAbstract
Periodontal disease is the term used to describe some pathological conditions characterized by degeneration and inflammation of gums, periodontal ligaments, alveolar bone, and dental cementum. Periodontal disease involves destruction of alveolar bone around the teeth leading to defects or rather loss of the tooth if left untreated. This condition is caused by a chronic, mixed infection of Gram-negative and Gram-positive bacteria. Chlorhexidine (CHX) gluconate is an antiseptic, antifungal and bactericidal agent. CHX inhibits plaque formation by binding to anionic salivary glycoproteins and bacteria. Nano Hydroxyapatite (nHAP) is calcium phosphate in morphology and composition like the human hard tissues. Delivery of medications directly into the periodontal pockets alters the inflammatory response and reduces the pathogenic microbiota, an aspect which has attracted great interes. Result: The CHX Nanocomposites were non-toxic to human cells and promoted cell adhesion, proliferation, and spreading. The CHX Nanocomposites were found to be satisfactory in all respects, and CHX encapsulated in nanocomposites may be attractive candidates for the treatment of periodontal disease.
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Jain, N., Jain, G.K., Javed, S., Iqbal, Z., Talegaonkar, S., Ahmad, F.J. and Khar, R.K., 2008. Recent approaches for the treatment of periodontitis. Drug discovery today, 13(21-22), 932-943.
Kinane, D.F., Stathopoulou, P.G. and Papapanou, P.N., 2017. Periodontal diseases. Nature reviews Disease primers, 3(1), 1-14.
Jayakaran, T. and Arjunkumar, R., 2015. Periodontal disease and rheumatoid arthritis–a review. IOSR Journal of Dental and Medical Sciences, 1(12), 1-4.
Greenstein, G., 1992. Periodontal response to mechanical non‐surgical therapy: A review. Journal of periodontology, 63(2), 118-130.
Paraskevas, S., Huizinga, J.D. and Loos, B.G., 2008. A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis. Journal of clinical periodontology, 35(4), 277-290.
Nazir, M. A. (2017). Prevalence of periodontal disease, its association with systemic diseases and prevention. International journal of health sciences, 11(2), 72.
Farooq, A., Yar, M., Khan, A.S., Shahzadi, L., Siddiqi, S.A., Mahmood, N., Rauf, A., Manzoor, F., Chaudhry, A.A. and ur Rehman, I., 2015. Synthesis of piroxicam loaded novel electrospun biodegradable nanocomposite scaffolds for periodontal regeneration. Materials Science and Engineering: C, 56, 104-113.
Kaur, M. and Kumar, K., 2016. Importance of Chlorhexidine in Maintaining Periodontal Health. IJDR, 1(1), 31-33.
Kaur, M., & Kumar, K. (2016). Importance of Chlorhexidine in Maintaining Periodontal Health. IJDR, 1(1), 31-33.
Karpanen, T. J., Casey, A. L., Conway, B. R., Lambert, P. A., & Elliott, T. S. (2011). Antimicrobial activity of a chlorhexidine intravascular catheter site gel dressing. Journal of antimicrobial chemotherapy, 66(8), 1777-1784.
Bodakhe, S., Verma, S., Garkhal, K., Samal, S.K., Sharma, S.S. and Kumar, N., 2013. Injectable photocrosslinkable Nanocomposite based on poly (glycerol sebacate) fumarate and hydroxyapatite: development, biocompatibility and bone regeneration in a rat calvarial bone defect model. Nanomedicine, 8(11), 1777-1795.
Nazir, M.S., Tahir, Z., Akhtar, M.N. and Abdullah, M.A., 2019. Biosorbents and composite cation exchanger for the treatment of heavy metals. In Applications of Ion Exchange Materials in the Environment (135159). Springer, Cham.
Gomes, D.S., Santos, A.M.C., Neves, G.A. and Menezes, R.R., 2019. A brief review on hydroxyapatite production and use in biomedicine. Cerâmica, 65, 282-302.
Aminu, N., Chan, S.Y. and Toh, S.M., 2017. Roles of nanotechnological approaches in periodontal disease therapy. J Appl Pharm Sci, 7(7), 234-42.
Okpala, C.C., 2013. Nanocomposites–an overview. International Journal of Engineering Research and Development, 8(11), 17-23.
Sun, L.X., Gou, W.W., Gao, X.L., Yang, Q., Zhang, Q.G., Zhu, A.M. and Liu, Q.L., 2021. End-group crosslinked hexafluorobenzene contained anion exchange membranes. International Journal of Hydrogen Energy, 46(80), 39921-39931.
Farooq, A., Yar, M., Khan, A.S., Shahzadi, L., Siddiqi, S.A., Mahmood, N., Rauf, A., Manzoor, F., Chaudhry, A.A. and ur Rehman, I., 2015. Synthesis of piroxicam loaded novel electrospun biodegradable nanocomposite scaffolds for periodontal regeneration. Materials Science and Engineering: C, 56, 104-113.
Garala, K., Joshi, P., Shah, M., Ramkishan, A. and Patel, J., 2013. Formulation and evaluation of periodontal in situ gel. International journal of pharmaceutical investigation, 3(1), 29.
https://www.abcam.com/kits/mtt-assay-protocol
Viswanatha KKRC, Reddy A, Elango N M (2019). Diabetes Kaggle Dataset Adequacy Scrutiny using Factor Exploration and Correlation, International Journal of Recent Technology and Engineering (IJRTE) Vol. 8.
Allugunti V.R (2022). A machine learning model for skin disease classification using convolution neural network. International Journal of Computing, Programming and Database Management 3(1), 141-147
Dr. Ritika Malik, Dr. Aarushi Kataria and Dr. Naveen Nandal, Analysis of Digital Wallets for Sustainability: A Comparative Analysis between Retailers and Customers, International Journal of Management, 11(7), 2020, pp. 358-370.
Said, A.H., Ahmed, H.Y., Ibrahim, I.H. and Sallam, A.M., 2022. Modification of food additive titanium dioxide (TiO 2 E171) with honey and thyme.
https://www.abcam.com/kits/mtt-assay-protocol
Dimitrievska, S., Petit, A., Ajji, A., Bureau, M.N. and Yahia, L.H., 2008. Biocompatibility of novel polymer‐apatite nanocomposite fibers. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 84(1), 44-53.
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