Investigation of sod2 gene polymorphism in the patients associated with type-2 diabetes mellitus patients
Keywords:
Superoxide dismutase 2, Diabetes mellitus, SOD2 geneAbstract
Introduction: Type-2 Diabetes mellitus (type-2DM) is a multifactorial metabolic disorder, characterized by hyperglycemia. Oxidative stress plays a crucial role in the progression of diabetes and its complications. The polymorphism in the SOD2 gene (superoxide dismutase) results in minimal production of SOD enzymes, which may affect the scavenging of free radicals. Aim: to see the level of SOD enzyme in type-2DM patients associated with SOD2 gene polymorphism. Material& Methods: It is a comparative study conducted in the department of anatomy in collaboration with the Department of General Medicine, RKDF medical college Hospital& research center, Bhopal. 5 ml of venous blood from type-2 DM patients (n=30) and control subject (n=30) was collected, followed by estimation of blood glucose (HbA1c, FBS& PPBS) and the genetic test was done to detect the SOD2 gene polymorphism. Results: Blood glucose levels (HbA1c, FBS &PPBS) were high and SOD levels were low in type-2 DM patients when compared with control subjects (p<0.05). When a comparison was done among three genotypes, the levels of SOD enzyme were high in the CC genotype followed by CT and TT genotypes.
Downloads
References
Banerjee M, Vats P. Reactive metabolites and antioxidant gene polymorphisms in type 2 diabetes mellitus. Redox Biol. 2014;2:170–7.
Banerjee M, Vats P. Reactive metabolites and antioxidant gene polymorphisms in type 2 diabetes mellitus. Redox Biol 2013;2C:170-177.
Bendlova B, Vejrazkova D, Vcelak J, Lukasova P, Burkonova D, Kunesova M, Vrbikova J, Dvorakova K, Vondra K, Vankova M. PPAR [gamma] 2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2. Physiol Res. 2008;57:S77-S90.
Joy SM, Little E, Maruthur NM, Purnell TS, Bridges JF. Patient preferences for the treatment of type 2 diabetes: a scoping review. Pharmacoeconomics. 2013; 31(1): 877-892.
K, Li X, Chen X, Ye X, Huang J, Jin Y, et al. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J Ethnopharmacol 2011;137 (3):1135-1142.
Karalliedde J, Gnudi L. Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease. Nephrol Dial Transplant 2016; 31: 206-213.
Liu L, Zheng T, Wang N, Wang F, Li M, Jiang J, Zhao R, Li L, Zhao W, Zhu Q, Jia W. The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes. Mol Cell Biochem. 2009;322(1):87–91.
Marrazzo G, Barbagallo I, Galvano F, Malaguarnera M, Gazzolo D, Frigiola A, et al. Role of dietary and endogenous antioxidants in diabetes. Crit Rev Food Sci Nutr. 2014; 54(12):1599-1616.
Milan Flekac, Jan Skrha, Jirina Hilgertova, Zdena Lacinova and Marcela Jarolimkova. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. BMC Medical Genetics. 2008; 9:(30)1-9.
Murea M, Ma L, Freedman BI. Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud. 2012;9(1):6–22.
Nagesh C , Kumar A , Kumar S , Nigam N. Study On Effect Of Vitamin-C As Add On Therapy With Antidiabetic Drugs In Type-2 Diabetes Mellitus Patients Associated With Sod2 Gene Polymorphism. J Adv Sci Res. 2021; 12 (2): 171-177.
Nagesh C, Nigam N, Kumar S, Kumar A. Study on effect of vitamin-c as add on therapy with antidiabetic drugs in newly diagnosed type-2 diabetes mellitus patients. J adv sci res. 2021; 12 (1) : 66-71.
Nigam N, Nagesh C, Kumar S , Kumar A. Journal of advanced scientific research.2021; 12 (1): 66-71
Petrovic MG, Cilensek I, Petrovic D. Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients. Dis Markers. 2008;24(1):59–64.
Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 2005;59(7): 365–73.
Simon D. Epidemiological features of type 2 diabetes. Rev Prat 2010; 60(4):469-73.
Tiwari BK, Pandey KB, Abidi AB, Rizvi SI. Markers of oxidative stress during diabetes mellitus. J Biomark.2013:378790.
uan Li, Xingping Shen. Oxidative stress and adipokine levels were signifcantly correlated in diabetic patients with hyperglycemic crises. Li and Shen Diabetol Metab Syndr. 2019; 11:(13)1-8.
Zahraa Kamil Kadhim Lawi. Investigation of SOD2 Gene Polymorphism in the Patients with Type Two Diabetes Disease in Babylon Province. Journal of Global Pharma Technology.| 2018; 10(6):70-75.
Zhao Y, Xu G, Wu W, Yi X. Type 2 Diabetes Mellitus- Disease, Diagnosis and Treatment. J Diabetes Metab.2015; 6: 533. doi: 10.4172/2155- 6156.1000533.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
