Evaluation of the immune response to silver nanoparticles against cutaneous leishmaniasis in albino mice Balbs/c

Zaid Nadhim Mohammed; Zainab Ali Hussein

doi:10.53730/ijhs.v6nS9.13215

Authors

Zaid Nadhim Mohammed
zaid.alhusainy654321@yahoo.com
Faculty of Education for Girls, University of Kufa, Iraq
Zainab Ali Hussein Faculty of Nursing, University of Kufa, Iraq

Keywords:

immune response, silver nanoparticles, Leishmaniasis

Abstract

Leishmaniasis is an epidemic disease that affects the human body and is transmitted through the bite of the sandfly insect, is the most common and causes skin lesions mainly ulcers on the exposed parts of the body. The results of the examination in the level of immunoglobulins IgM and INF-ϒ concentration of one of the cellular kinetics showed that there was a significant increase of P<0.05 in the sera of mice of the positive control group (first) infected with cutaneous leishmaniasis, compared with the negative control group (second). The results also showed that the drug pentostam (Sb), silver nanoparticle (AgNPs) and the loaded drug (AgNPs + Sb) had a significant effect on a decrease in the rate of immunoglobulins IgM and the lowest concentration rate was in the serum of mice treated with the drug loaded with silver nanoparticles. (AgNPs + Sb), while there was an increase in the average (INF -ϒ) concentration, where the highest concentration was in the group of mice treated with the drug loaded with silver nanoparticles (AgNPs + Sb) compared with the positive control group infected with cutaneous leishmaniasis,,,,

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