Elevated IL-31 and IL-31RA with dyslipidemia in T2DM patients

Aya Refat Eswadi; Zainab Hussein Al-Hallawi

doi:10.53730/ijhs.v6nS10.13309

Authors

Aya Refat Eswadi Department of Chemistry, Faculty of Science, Kufa University, Najaf, Iraq
Zainab Hussein Al-Hallawi
Zainab.alhillawi@uokufa.edu.iq
Department of Chemistry, Faculty of Science, Kufa University, Najaf, Iraq

Keywords:

diabetes foot ulcers, inflammation, lipids, interleukins

Abstract

Type 2 Diabetes mellitus (T2DM) is characterized by elevated of blood glucose, and considered as a chronic metabolic disease. Uncontrolled blood glucose levels cause many dangerous complications. One of these complications are diabetic foot ulcers (DFU). About 15% of these patients suffering of DFU that affected on their lives. Approximately 8.5% Iraqi suffer from T2DM. Sixty T2DM patients (32 male and 28 female) aged 39-65 years that participated in the present study. Thirty apparently healthy subjects (12 male and 18 female) were classified as a control group. Age and BMI are not significantly different between patients and controls. This was made to exclude the influence of body mass and age on the results. There is an expected significant increase in fasting blood glucose (FBG) (p <0.001) and glycated hemoglobin (HbA1c). The results showed a significant increase (p<0.001) in serum triglyceride (TG), VLDLc in T2DM as comparison with the control group, while There were no significant differences among T2DM patients and control group in total cholesterol (TC), HDLc and LDLc. This result maybe was by the effect of diabetic drug on lipid profile where some drugs such as metformin that reducing cholesterol.

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