Caspase-3, liver function test and trace elements in Iraqi women with breast cancer

Buraq Mashaan Attallah; Wajeeh Y. Al-Ani; Nafea S. Alboaisa

doi:10.53730/ijhs.v6nS10.13320

Authors

Buraq Mashaan Attallah College of Sciences/University of Anbar
Wajeeh Y. Al-Ani College of Sciences/University of Anbar
Nafea S. Alboaisa College of Medicine/ University of Anbar

Keywords:

caspace-3, breast cancer, trace elements, statistical analysis

Abstract

Introduction: Cancer is a class of diseases characterized by out-of-control cell growth. Breast cancer is most common disease among women. Aim: The aim of this study to investigate Caspase-3, liver enzyme and trace elements (Iron, magnesium and phosphorus) in women whose suffered from breast cancer. Materials and Methods: Three groups of Iraqi women were chosen named group I (50 healthy women), group II (32 patients new diagnosed with breast cancer and do not take chemotherapy) and group III (43 patients have taken chemotherapy). From the results, On the other hand, the study have been measurement of some biochemical variables, including caspase-3 enzyme, liver enzymes (ALT, AST, ALP) and measuring important trace elements that may have an effect on breast cancer, which included (magnesium, iron and phosphorous). Results: The results showed a significant decrease (P<0.05) between group I and group II in both magnesium and ALT. There was a significant decrease between the group I and the group III in magnesium and a significant increase (P<0.05) between the group I and the group II in iron. In addition, AST and iron levels increased significantly between groups I and III.

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References

E. Aloisio, G. Colombo, C. Arrigo, A. Dolci, and M. Panteghini, “Sources and clinical significance of aspartate aminotransferase increases in COVID-19,” Clin. Chim. Acta, vol. 522, pp. 88–95, 2021.

H. A. El-Beshbishy, A. M. Mohamadin, A. A. Nagy, and A. B. Abdel-Naim, “Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin,” Indian J. experimantal Biol., vol. 48, pp. 280–288, 2010.

H. Alta, M. Ewadh, and Z. Kamil, “Role of Some Trace Elements in Breast Cancer Receiving Chemotherapy,” Int. J. PharmTech Res., vol. 9, no. 5, pp. 381–386, 2016, [Online]. Available: https://www.researchgate.net/publication/303913165.

H. R. Brewer, M. E. Jones, M. J. Schoemaker, A. Ashworth, and A. J. Swerdlow, “Family history and risk of breast cancer: an analysis accounting for family structure,” Breast Cancer Res. Treat., vol. 165, no. 1, pp. 193–200, 2017.

J. G. Ionescu, J. Novotny, V. Stejskal, A. Lätsch, E. Blaurock-Busch, and M. Eisenmann-Klein, “Increased levels of transition metals in breast cancer tissue,” Neuroendocrinol. Lett., vol. 27, no. SUPPL. 1, pp. 36–39, 2006.

J. Sariego, “Breast cancer in the young patient,” Am. Surg., vol. 76, no. 12, pp. 1397–1400, 2010.

K. A. Amin, B. M. Mohamed, M. A. M. El-wakil, and S. O. Ibrahem, “Breast Cancer Impact of Breast Cancer and Combination Chemotherapy on Oxidative Stress , Hepatic and Cardiac Markers,” ejbc, vol. 15, no. 3, pp. 306–312, 2012, [Online]. Available: http://dx.doi.org/10.4048/jbc.2012.15.3.306.

K. Mcpherson, C. M. Steel, and J. M. Dixon, “APC of Breast Diseases : Breast Cancer - Epidemiology , risk factors , and Genetics Breast cancer — epidemiology , risk factors , and genetics Risk factors for breast cancer,” no. October, 2000, doi: 10.1136/bmj.309.6960.1003.

L. Zhao et al., “Metabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using GC/TOF MS,” Evidence-Based Complement. Altern. Med., vol. 2013, 2013.

M. A. de la Cruz-Morcillo et al., “Abrogation of the p38 MAPK α signaling pathway does not promote radioresistance but its activity is required for 5-Fluorouracil-associated radiosensitivity.,” Cancer Lett., vol. 335, no. 1, pp. 66–74, 2013.

M. Alfonse, M. M. Aref, and A.-B. M. Salem, “An Ontology-Based System for Cancer Diseases Knowledge Management,” Int. J. Inf. Eng. Electron. Bus., vol. 6, no. 6, pp. 55–63, 2014, doi: 10.5815/ijieeb.2014.06.07.

M. W. Saif, “Management of hypomagnesemia in cancer patients receiving chemotherapy,” J. Support. Oncol., vol. 6, no. 5, pp. 243–248, 2008.

M. Yasin, H. Muzaffar, M. A. Zamir, T. Munir, A. Mahmood, and A. Khalid, “To determine the diagnostic accuracy of aspartate aminotransferase to platelet ratio index in detecting significant fibrosis in chronic hepatitis C patients by using histopathology as gold standard.,” Prof. Med. J., vol. 28, no. 08, pp. 1166–1171, 2021.

M. Zhou, X. Liu, Z. Li, Q. Huang, F. Li, and C. Li, “Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells,” Int. J. cancer, vol. 143, no. 4, pp. 921–930, 2018, doi: 10.1002/ijc.31374.

Mohammed Abbood Mohammed, “Synthesis and Characterization of Complex for Anti-Breast Cancer, activity evaluation on Cell Line MCF-7 and Study of some Biochemical Parameters in Women with the disease,” 2018.

Murata et al., “One-dimensional sliding of p53 along DNA is accelerated in the presence of Ca2+ or Mg2+ at millimolar concentrations,” J. Mol. Biol., vol. 427, no. 16, pp. 2663–2678, 2015.

N. W. Tietz, P. R. Finley, and E. L. Pruden, Clinical guide to laboratory tests, vol. 624. WB Saunders company Philadelphia, 1995.

P. Chauhan, R. Yadav, V. Kaushal, and P. Beniwal, “Evaluation of serum biochemical profile of breast cancer patients,” Int. J. Med. Res., vol. 5, no. 7, pp. 1–7, 2016.

P. Wen et al., “High Serum Iron Is Associated with Increased Cancer Risk,” Am. Assoc. Cancer Res., vol. 74, no. 22, pp. 6589–6598, 2014, doi: 10.1158/0008-5472.CAN-14-0360.

S. Iqbal and I. Ali, “Dietary Trace Element Intake and Risk of Breast Cancer: A Mini Review,” Biol. Trace Elem. Res., pp. 1–13, 2022.

Sasu et al., “Protective effects of silymarin on epirubicin-induced hepatotoxicity in mice,” Stud. Univ. Vasile Goldis" Arad. Ser. Stiint. Vietii (Life Sci. Ser., vol. 26, no. 3, p. 305, 2016.

W. Guo et al., “Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population,” Eur. J. Clin. Invest., vol. 51, no. 8, p. e13560, 2021.

W. M. Merza, M. S. Daoud, and A. M. Jawad, “Serum magnesium concentration in patients with leukemia and lymphoma,” J. Fac. Med. Baghdad, vol. 51, no. 1, pp. 101–104, 2009.

Y. Xiao et al., “Dynamic serum alkaline phosphatase is an indicator of overall survival in pancreatic cancer,” BMC Cancer, vol. 19, no. 1, pp. 1–8, 2019.

Z. Liu, S. Que, J. Xu, and T. Peng, “Alanine Aminotransferase-Old Biomarker and New Concept : A Review,” Int. J. Med. Sci., vol. 11, no. 9, pp. 925–935, 2014, doi: 10.7150/ijms.8951.

Z. N. Anber, “Effect of doxorubicin and cyclophosphamide regimen versus taxane on liver enzymes in Iraqi women with breast cancer,” Biomed. Res., vol. 29, no. 21, pp. 3869–3873, 2018.