Normal anemia caused by endocrine disease
Case study from Jordan
Keywords:
Anemia, Thyroid Disorders, Hemoglobin, Hematocrit, Red BloodAbstract
Anemia is a common condition in patients with thyroid disorders. This paper focuses on demonstrating that changes in hemoglobin concentration, hematocrit, red blood cell count and erythrocyte indices influence the development of this pathology. The reduced half-life and decreased erythropoietin production of red blood cells and proliferation of blood cell precursors in the bone marrow made it possible to establish a relationship between the patient's symptoms and the prevailing laboratory findings between anemia and hypothyroidism.
Downloads
References
Ashraf, T. S., De Sanctis, V., Yassin, M., Wagdy, M., & Soliman, N. (2017). Chronic anemia and thyroid function. Acta Bio Medica: Atenei Parmensis, 88(1), 119.
Asleh, R., Levy, A. P., Levy, N. S., Asleh, A., Goldenstein, H., Segol, I., ... & Lerman, A. (2019). Haptoglobin Phenotype Is Associated With High-Density Lipoprotein–Bound Hemoglobin Content and Coronary Endothelial Dysfunction in Patients With Mild Nonobstructive Coronary Artery Disease. Arteriosclerosis, thrombosis, and vascular biology, 39(4), 774-786.
Bocci, V., Borrelli, E., Travagli, V., & Zanardi, I. (2009). The ozone paradox: ozone is a strong oxidant as well as a medical drug. Medicinal research reviews, 29(4), 646-682.
Briggs, C. (2009). Quality counts: new parameters in blood cell counting. International journal of laboratory hematology, 31(3), 277-297.
Buttarello, M. (2016). Laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment, how?. International journal of laboratory hematology, 38, 123-132.
Camaschella, C. (2017). New insights into iron deficiency and iron deficiency anemia. Blood reviews, 31(4), 225-233.
Carter, C. M. (2018). Alterations in Blood Components. Comprehensive Toxicology, 249.
Dameshek, W. (1950). Physiopathology and course of polycythemia vera as related to therapy. Journal of the American Medical Association, 142(11), 790-797.
Davidenko, V., Shtyker, S. Y., Belopaschentcev, V. A., Paschenko, Y. V., & Vjun, V. V. (2011). Pediatric Surgery: textbook for medical students.
De Benoist, B., Cogswell, M., Egli, I., & McLean, E. (2008). Worldwide prevalence of anaemia 1993-2005; WHO global database of anaemia.
Dobay, M. P., Lemonnier, F., Missiaglia, E., Bastard, C., Vallois, D., Jais, J. P., ... & Gaulard, P. (2017). Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin. Haematologica, 102(4), e148.
Dubaj, C., Czyż, K., & Furmaga-Jabłońska, W. (2020). Vitamin B 12 deficiency as a cause of severe neurological symptoms in breast fed infant–a case report. Italian journal of pediatrics, 46(1), 1-6.
Elstrott, B., Khan, L., Olson, S., Raghunathan, V., DeLoughery, T., & Shatzel, J. J. (2020). The role of iron repletion in adult iron deficiency anemia and other diseases. European journal of haematology, 104(3), 153-161.
Etim, N. N., Williams, M. E., Akpabio, U., & Offiong, E. E. (2014). Haematological parameters and factors affecting their values. Agricultural Science, 2(1), 37-47.
Ganz, T., & Nemeth, E. (2012). Hepcidin and iron homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1823(9), 1434-1443.
Gholipourmalekabadi, M., Mozafari, M., Salehi, M., Seifalian, A., Bandehpour, M., Ghanbarian, H., ... & Seifalian, A. M. (2015). Development of a cost‐effective and simple protocol for decellularization and preservation of human amniotic membrane as a soft tissue replacement and delivery system for bone marrow stromal cells. Advanced healthcare materials, 4(6), 918-926.
Glenn, A., & Armstrong, C. E. (2019). Physiology of red and white blood cells. Anaesthesia & Intensive Care Medicine, 20(3), 170-174.
Gupta, C. P. (2014). Role of iron (Fe) in body. IOSR Journal of Applied Chemistry, 7(11), 38-46.
Handin, R. I., Lux, S. E., & Stossel, T. P. (Eds.). (2003). Blood: principles and practice of hematology (Vol. 1). Lippincott Williams & Wilkins.
Hess, S. Y. (2010). The impact of common micronutrient deficiencies on iodine and thyroid metabolism: the evidence from human studies. Best Practice & Research Clinical Endocrinology & Metabolism, 24(1), 117-132.
Ibrahim, R. Y. O. (2018). Screening of Platelets Count and Function in Women with Menorrhagia in Wad Medani Maternity Teaching Hospital, Gezira State, Sudan (2017) (Doctoral dissertation, University of Gezira).
Khanam, S., & Khan, B. (2021). Socioeconomic Impact and Prevalence of Anemia Among Pregnant Women Attending Yobe State Specialist Hospital, Damaturu, North-East Nigeria. SN Comprehensive Clinical Medicine, 3(5), 1115-1121.
Koc, D. O., & Kegin, M. (2020). Role of Red Cell Distribution Width in Evaluation of Inflammatory Bowel Disease Activity. Journal of Academic Research in Medicine, 10(3), 214-220.
Kosmachevskaya, O. V., Novikova, N. N., & Topunov, A. F. (2021). Carbonyl Stress in Red Blood Cells and Hemoglobin. Antioxidants, 10(2), 253.
Lanzkowsky, P. (Ed.). (2005). Manual of pediatric hematology and oncology. Elsevier.
Lee, J., & Powell, L. (2013). Emergency Medicine, An Issue of Veterinary Clinics: Small Animal Practice, E-Book (Vol. 43, No. 4). Elsevier Health Sciences.
Lee, N. H. (2020). Iron deficiency anemia. Clinical Pediatric Hematology-Oncology, 27(2), 101-112.
Lim, W. H., Choi, E. K., Han, K. D., Lee, S. R., Cha, M. J., & Oh, S. (2020). Impact of hemoglobin levels and their dynamic changes on the risk of atrial fibrillation: a nationwide population-based study. Scientific reports, 10(1), 1-8.
Lippi, G., Targher, G., Montagnana, M., Salvagno, G. L., Zoppini, G., & Guidi, G. C. (2008). Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scandinavian journal of clinical and laboratory investigation, 68(8), 745-748.
Liu, W. L., Liu, T., Zou, M. Z., Yu, W. Y., Li, C. X., He, Z. Y., ... & Zhang, X. Z. (2018). Aggressive man‐made red blood cells for hypoxia‐resistant photodynamic therapy. Advanced Materials, 30(35), 1802006.
Mairbäurl, H. (2013). Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Frontiers in physiology, 4, 332.
Mitrosz, M., Chlabicz, M., Hapaniuk, K., Kaminski, K. A., Sobkowicz, B., Piszcz, J., ... & Tycinska, A. M. (2017). Thrombocytopenia associated with TAVI—The summary of possible causes. Advances in medical sciences, 62(2), 378-382.
Paller, A. S., & Mancini, A. J. (2015). Hurwitz clinical pediatric dermatology: a textbook of skin disorders of childhood and adolescence. Elsevier Health Sciences.
Pasternak, J. J., & Lanier Jr, W. L. (2008). Spinal cord disorders. Stoelting's Anesthesia and Co-existing Disease, 5, 230-1.
Pischik, E. (2006). Neurological manifestations and molecular genetics of acute intermittent porphyria in North Western Russia.
Salama, M. A. S., Sadek, N. A., Hassab, H. M. A., Abadeer, A. F., & Mikhael, I. L. (2004). Erythrocyte autoantibodies and expression of CD59 on the surface of red blood cells of polytransfused patients with ß-thalassaemia major. British journal of biomedical science, 61(2), 88-92.
Sánchez, Á., Contreras-Jurado, C., Rodríguez, D., Regadera, J., Alemany, S., & Aranda, A. (2020). Hematopoiesis in aged female mice devoid of thyroid hormone receptors. Journal of Endocrinology, 244(1), 83-94.
Sanju, U. (2019). A Comparative study of Diagnostic Value of Hyperbilirubinemia in Predicting Appendicitis and Its Complications (Doctoral dissertation, Madurai Medical College, Madurai).
Sazawal, S., Dhingra, U., Dhingra, P., Dutta, A., Shabir, H., Menon, V. P., & Black, R. E. (2014). Efficiency of red cell distribution width in identification of children aged 1-3 years with iron deficiency anemia against traditional hematological markers. BMC pediatrics, 14(1), 1-6.
Shubham, K., Anukiruthika, T., Dutta, S., Kashyap, A. V., Moses, J. A., & Anandharamakrishnan, C. (2020). Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches. Trends in Food Science & Technology, 99, 58-75.
Sueters, M., & Oepkes, D. (2014). Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. Best Practice & Research Clinical Obstetrics & Gynaecology, 28(2), 215-226.
Tham, T., Olson, C., Wotman, M., Teegala, S., Khaymovich, J., Coury, J., & Costantino, P. (2018). Evaluation of the prognostic utility of the hemoglobin-to-red cell distribution width ratio in head and neck cancer. European Archives of Oto-Rhino-Laryngology, 275(11), 2869-2878.
WHO (World Health Organization). (2011). Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization.
WHO (World Health Organization). (2015). World health statistics 2015. World Health Organization.
Xiong, X. F., Yang, Y., Chen, X., Zhu, X., Hu, C., Han, Y., ... & Sun, L. (2017). Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients. Scientific reports, 7(1), 1-9.
Zhang, Y., Kremsdorf, R. A., Sperati, C. J., Henriksen, K. J., Mori, M., Goodfellow, R. X., ... & Smith, R. J. (2020). Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. Kidney international, 98(5), 1265-1274.
Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., ... & Zhao, J. (2017). Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood, The Journal of the American Society of Hematology, 130(20), 2161-2170.
Zimmermann, M. B. (2008). Iodine requirements and the risks and benefits of correcting iodine deficiency in populations. Journal of Trace Elements in Medicine and Biology, 22(2), 81-92.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








