Congenital goitre and respiratory distress as rare presenting features of congenital hypothyroidism in the newborns
Keywords:
Goiter, respiratory distress, newborn, primary hypothyroidismAbstract
In babies with congenital hypothyroidism, congenital goiter and respiratory distress (due to upper airway compression/hypothyroidism) are rarely encountered as the first presenting signs. Computerized Tomography of the neck revealed enlargement of all thyroid gland lobes and further laboratory revealed hypothyroidism. Thyroid hormone replacement therapy was initiated early, which resulted in a significant reduction in respiratory distress and goiter regression. With a high TSH, a low Tri-iodothyronin, no central line abnormality, no maternal history of drug/s use during pregnancy, and no familial history of hypothyroidism, Congenital Goitrous Primary Hypothyroidism is the most likely diagnosis.
Downloads
References
Alm J, Hagenfeldt L, Larsson A, Lundberg K. Incidence of congenital hypothyroidism: retrospective study of neonatal laboratory screening versus clinical symptoms as indicators leading to diagnosis. Br Med J (Clin Res Ed) 1984; 289:1171.
Dussault JH, Coulombe P, Laberge C, et al. Preliminary report on a mass screening program for neonatal hypothyroidism. J Pediatr 1975; 86:670.
Felner EI. A newborn with a goiter and thyroid dyshormonogenesis. J MaternalFetal & Neonatal Med. 2002;12(3):207-8.
Fisher DA. Second International Conference on Neonatal Thyroid Screening: progress report. J Pediatr 1983; 102:653.
Klein AH, Meltzer S, Kenny FM. Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr 1972; 81:912.
LaFranchi SH, Murphey WH, Foley TP Jr, et al. Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics 1979; 63:180.
Muir A, Daneman D, Daneman A, Ehrlich R. Thyroid scanning, ultrasound, and serum thyroglobulin in determining the origin of congenital hypothyroidism. Am J Dis Child 1988; 142:214.
Schoen EJ, Clapp W, To TT, Fireman BH. The key role of newborn thyroid scintigraphy with isotopic iodide (123I) in defining and managing congenital hypothyroidism. Pediatrics 2004; 114:e683.
Stephen LaFranchi , Mitchell E Geffner , Alison G Hoppin , Clinical features and detection of congenital hypothyroidism, UpToDate, update March 03, 2020.
Worth C, Hird B, Tetlow L, et al. Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism. Arch Dis Child 2019.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
