An overview of the synthesis, therapeutic potential and patents of thiazole derivatives
Keywords:
thiazole, heterocycles, synthesis, biological activities, anticancer, antiprotozoal, anti-inflammatoryAbstract
Thiazole is a nitrogen and sulphur containing heterocyclic five membered aromatic ring. Thiazole derivatives exhibited various medicinal applications in the treatment of cancer, diabetes, inflammation, microbial infections, psychosis etc. These are also naturally obtained from cyanobacteria, sea slugs, sea hare, red algae and higher plants. Thiazole derivatives can be synthesized by reaction of aldehyde and ⍺-halo carbonyl coumarin. The present paper provides an overview of different methods used for synthesis of thiazole and various biological targets of thiazole derivatives. Further, various patents related to pharmacological activities of thiazole derivatives published in last five years have been summarized. Hence, present review may provide reference for design and development of new thiazole derivatives with significant biological activities.
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