The relationship between vitamin D deficiency and preeclampsia
Keywords:
relationship, vitamin D deficiency, preeclampsiaAbstract
Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. Vitamin D deficiency has been associated with several adverse pregnancy outcomes. Aim: The current study aimed to determine the relationship between vitamin D deficiency and preeclampsia. Research Design: A case control design. Setting: The study was conducted at the antenatal clinic at Al zahraa hospital – Al-Azhar University, Cairo, Egypt. Sample: Purposive sample (120 pregnant women), was divided into study group (n=60) and control group (n=60). Tools: Two tools for data collection. First tool: A structured interviewing questionnaire which used to assess demographic data, obstetrical history, family history, physical examination to diagnose preeclampsia and laboratory investigation to confirm the diagnosis. Second tool: Serum vitamin D levels of both groups were measured by using an Enzyme Linked Immunosorbent Assay (ELISA) technique. Result: Significant lower mean vitamin D of study group compared to control group with highly statistical significant difference between both groups. In addition, there were 3-fold increased odds of developing preeclampsia in pregnant women who had vitamin D deficiency (<20 ng/ml). Also, observed that when vitamin D level decreases, the severity of preeclampsia increases.
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Ali, S.A., Faris, T., & Abd Elaziz, A.F., (2018): Ratio between Low Serum Maternal 25-Hydroxy vitamin D Concentration and the Risk of Preeclampsia. The Egyptian Journal of Hospital Medicine, 72(8): P 5044-5049. https://doi.org/10.21608/EJHM.2018.10285
Alsaeed, S.H., Mohammed, N.H., Nassef, A.H. & Almadbouly, A.A., (2020): The relation between vitamin D level in the third trimester and preeclampsia. Evidence Based Women's Health Journal, 10 (2): P 127 - 132. https://doi.org/10.21608/ebwhj.2019.21449.1068
Ameen, R.A., Hany, A.M.M., & Ali, A.A., (2020): Prevalence rate and risk factors for preeclampsia and eclampsia among pregnant women attending Qena University Hospital During COVID-19 pandemic. SVU-International Journal of Medical Sciences, 6 (1): P 29-37. https://doi.org/10.21608/svuijm.2022.147371.1330
Benachia, A., Baptiste, A., Taieb, J., Tsatsaris, V., Guibourdenche, J., Senat, M.V., Jani, J., Guizani, M., Jouannic, J.M., Haguet, M.C., Winer, N., Masson, D., Courbebaisse, M., Elie, C., & Souberbielle, J.C., (2020): Relationship between vitamin D status in pregnancy and the risk for preeclampsia: A nested case-control study. Clinical Nutrition, 39 (2): P 440-446. https://doi.org/10.1016/j.clnu.2019.02.015
Das, B., Singhal, S.R., & Ghalaut, V.S., (2021): Evaluating the association between maternal vitamin D deficiency and preeclampsia among Indian gravidas. European Journal of Obstetrics & Gynecology and Reproductive Biology, 261: p103-109. https://doi.org/10.1016/j.ejogrb.2021.04.014
Fondjo, L.A., Tashie, W., Owiredu, W.K.B.A., Adu-Gyamfi, E.A., & Seidu, L., (2021): High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana. BMC pregnancy and childbirth, 21(1): p 1-8. https://doi.org/10.1186/s12884-021-03802-9
Gupta, M., & Patel, N., (2021): Evaluation of Vitamin D Levels In Pregnancy Induced Hypertension. International Journal of Health and Clinical Research, 4 (10): P 115 - 117. https://www.ijhcr.com/index.php/ijhcr/article/view/1602
Hu, K.L., Zhang, C.X., Chen, P., Zhang, D., & Hunt, S., (2022): Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis. Nutrients, 14(5): P 999. https://doi.org/10.3390/nu14050999.
Jindal, S., Sharma, J.C., & Sharma, M., (2019): Association of Deficiency of Maternal Vitamin D Levels with Severity of Preeclampsia. Epidemiology International, 4(3): p 10-16. https://doi.org/10.24321/2455.7048.201913
Karpa, M., Thakur, S., Singh, K., Jyoti Sharma, J., & Chaudhary, H., (2022): To compare serum Vitamin D status in pre-eclamptic and non-preeclamptic pregnant women in labour: A tertiary care centre study of Northern India. Clinical Journal of Obstetrics and Gynecology, 5 (1): P 013-018. https://doi.org/10.29328/journal.cjog.1001100
Lewis, J.A., (1999): Statistical Principles for Clinical Trials (ICH E9) an Introductory Note on an International Guideline. Statistics in Medicine, 18: P 1903-1904.
Mareg M., Molla A., Dires S., Mamo, Z.B., & Hagos, B., (2020): Determinants of preeclampsia among pregnant mothers attending antenatal care (ANC) and delivery service in gedeo zone, southern Ethiopia: case control-study. International Journal of Women's Health, 12: P 567 – 575. https://doi.org/10.2147/IJWH.S251342
Masnavi, E., Hosseini, M., Aramesh, S.H., & Hassanzadeh, S., (2022): Is There a Relationship between Vitamin D and Preeclampsia? A Descriptive Comparative Study. Journal of Clinical Care and Skills, 3(2): p 1-7. http://jccs.yums.ac.ir/article-1-135-en.html
Mou, A.D., Barman, Z., Hasan M., Miah, R., Hafsa, J.M., Trisha, A.D., & Ali, N., (2021): Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Scientific Reports, 11 (21339): P 1-9. https://doi.org/10.1038/s41598-021-00839-w
Ni, M., Zhang, Q., Zhao, J., Shen, Q., Yao, D., Wang, T., & Liu, Z., (2021): Relationship between maternal vitamin D status in the first trimester of pregnancy and maternal and neonatal outcomes: a retrospective single center study. BMC pediatrics, 21(1): P 1-14. https://doi.org/10.1186/s12887-021-02730-z
Osman, O.M., Gaafar, T., Eissa, T.S., Abdella, R., Ebrashy, A., & Ellithy, A., (2020): Prevalence of vitamin D deficiency in Egyptian patients with pregnancy-induced hypertension. Journal of Perinatal and Medical, 48(6): P 583 – 588. https://doi.org/10.1515/jpm-2020-0055
Raia-Barjat, T., Sarkis, C., Rancon, F., Thibaudin, L., Gris, J.C., Alfaidy, N., & Chauleur, C., (2021): Vitamin D deficiency during late pregnancy mediates placenta-associated complications. Scientific Reports, 11 (20708). https://doi.org/10.1038/s41598-021-00250-5
Ramadan, A., Abo Shabana, K. & Mossa, S., (2021): Assessment of post abortion woman lifestyle. Egyptian Journal of Health Care, 12 (3): P 831-842. https://doi.org/10.21608/EJHC.2021.192060
Richard, K.K., Marcelline, B.S., Jean-Pierre, E.M., & Pierrot, L.T., (2020): Vitamin D Status and the Determinants of Preeclampsia in Pregnant Women in Goma (Democratic Republic of the Congo). Open Journal of Obstetrics and Gynecology, 10 (6): p 820. https://doi.org/10.4236/ojog.2020.1060077
Seifer, D.B., Lambert-Messerlian, G., Palomaki, G.E., Silver, R.M., Parker, C., Hogue, C.J.R., Stoll, B.J., Saade, G.R., Goldenberg, R.L., Dudley, D.J., Bukowski, R., Pinar, H., & Reddy, U.M., (2022): Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study. Reproductive Biology and Endocrinology, 20 (1): P 8. https://doi.org/10.1186/s12958-021-00885-z
Serrano, N.C., Guio, E., Quintero-Lesmes, D.C., Becerra-Bayona, S., Luna-Gonzalez, M.L., Herrera, V.M., & Pradra, C.E., (2018): Vitamin D deficiency and pre-eclampsia in Colombia: PREVitD study. Pregnancy Hypertension, 14 (1): P 240–244. https://doi.org/10.1016/j.preghy.2018.03.006
Shahid, S., Ladak, A., Fatima, S.S., Zaidi, F.A., & Farhat, S., (2020): Association of vitamin D levels with preeclampsia. Journal of the Pakistan Medical Association, 70 (12): p 2390-2393. https://doi.org/10.47391/JPMA.414
Sharma, A., Choudhary, J., Joshi P., & Bardhar N., (2020): Prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women. International Journal of Research in Medical Sciences, 8 (12): P 4383-4387. https://dx.doi.org/10.18203/2320-6012.ijrms20205310
Sherief, L.M., Ali, A., Gaballa A., Abdellatif, G. M., Kamal, N.M., Afify, M.R., Abdelmalek, D.H., El-Emari, S.A., Soliman, A.S.A., & Mokhtar, W.A., (2021): Vitamin D status and healthy Egyptian adolescents. Medicine (Baltimore), 100 (29): e26661. https://doi.org/10.1097/MD.0000000000026661
Siddiqee, M.H., Bhattacharjee, B., Siddiqi, U.R., & MeshbahurRahman, M., (2021): High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis. BMC Public Health, 21 (1823): P 1-18. https://doi.org/10.1186/s12889-021-11888-1
Tammo, O., & Yildiz S., (2022): Vitamin D Deficiency and Its Clinical Results in Preeclamptic Mothers and Their Babies. Cureus, 14(3): e23519. https://doi.org/10.7759/cureus.23519
Wei, S.Q., Bilodeau, J.F., Julien, P., Luo, Z.C., Abenhaim, H.A., Bi, W.G., Nuyt, A.M., Leduc, L., Audibert, F., & Fraser, W.D., (2021): Maternal vitamin D, oxidative stress, and pre‐eclampsia. International Journal of Gynecology & Obstetrics, 154(3): P 444 - 450. https://doi.org/10.1002/ijgo.13559
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