Synthesis, characterization of some derivationes of 3-Nicotinc acide
Keywords:
Nicotinic acide, Nicotonyl Chlorid, Nicotino hydrazide, oxadiazoleAbstract
In This Research The Preparation Of Number heterocyclic compounds, Which include Seminars like compensators 1,3,4- oxadizole -2-thiol and AL Pyrazole -2- yl, Nicotinic Used as Vaw material in the Preparation .Attended ester During reactance nicotinic acid With thionyl Chloride in the presence of ethanol, The resultant ester were treated with hydrazine hydrate in ethanol the Corresponding hydrazide The synthesized hydrazides were converted to 1,3,4-oxadizoles by their reaction with carbon disulfide in potassium hydroxide, Use hydrazide To the praparation pyrazole during reactance with ethyl acetoacetate.
Downloads
References
Niacin"Drug Bank :a know lodge base for drugs" drug actions and drug targets,48, (2019)
Niacin-pubchem public chemical Database" The pub chem. project use National center for Biote chnology In formation,84. (2014)
M. ElBairi, K, Amzazi .s. Toxicological properties of fenugreek "Trigonella foenum graecum ", 159 (2016)
D.Hathcock, J. Guarneri "Niacin: chemical forms, bioavailbility, and heal the effects" 345-295 (2016)
Rolfe, Heidi M " Journal of cosmetic Dermatology, 324-328 .(2017)
Schulze and Trier, Zeit, physiol, chem, (40) (2020)
B.Valerie, (Neuronal nicotinic receptors from protein structure to function) (2001)
H. Gilman, Org.Syn.Coll.,Vol.1,John Wiley and sons, New York, p394 (1941)
M.N. Ibrahim, M.S. Saeed and S. Fadhil, J .Iraqi Chem. Soc. P159.(1987)
Ayman El-Faham, Zainab Al-Marhoom, Ahmed Abdel-Megeed and, Mohamed. S, Journal of Chemistry, Saudi University, 1,6, (2013)
M.Amir, K. Shika, J. Europ. Med. Chem. 39,535, (2004)
M.I.EL-Zahar,s.s.El-Karim, M.E .Haiba, World Journal of Chemistry,182-194 (2009)
A. S. Founda, M.M. Gouda and S. I. Abed EL-rahman, Bull .Korean chem. Soc, 21(11),1085-82,(2000)
L. Zhang, A. Zhang, X.X. Chen, X.X. Lei, X.Y. Nan, D. Y. Chen and Z.Y.Zhang,Molecules,7,681-689,(2000).
F.C. Charles and F.W. Mary, Experimental organic chemistry-A Small Scale Approach, Prentice Hall, Englewood Cliffs, New jersey, 2ed ed, USA,59, (1995)
A Shish Kumar Tewari and Anil Mishra, Indian Journal of chemistry, 8,234, (2006)
Ayman El-faham, Zainab Al-Marhoom Ahmed Abdel-Megeedand, Mohamed.s, Journal of chemistry, Saudi University, (2013)
E.Diez-Cecilica, B.Kelly, and I. Rozas, Tetrahedraon Letters (2011)
S.J,Sinclair, R. Johnson and J.D, Hamil, Analysis of activities compound in Nicotianna species with contrasting alkaloid profiles functional plant Biology,(2004)
J.P Greenstein , M. Wintz (chemistry of the amino acids) John Wiley and Sons, INC , New york, (1986)
Rajeer Bhimwal, Anil .k. Sharma, Ankit Jain, Journal of Advanced pharmacy Education and Research, 251-258, (2011)
L.J. Bellomy. "The origin of group frequency shift abnormal frequencies in multiple bonds" Spectrochemica Acta, pergamon press, ltd, London,(66), (1958)
F.E.M.EL. Baih, J. saudi chem. Soc ,( 59) (2004)
K.M. Daoud, A.K. Ahmed J. educ. sci. (40). (2000)
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








