Recent developments in bioactive pulp capping materials (direct and indirect)
A review
Keywords:
recent developments, bioactive pulp capping materials, direct, indirectAbstract
The field of dentistry is rapidly shifting its focus toward biologically active restorative materials. Bioactive materials are those capable of inducing and promoting the regeneration of the damaged tissue and remineralizing demineralized dentinal structure as a vital dental pulp is necessary for the long-term healthy survival of a tooth. Vital pulp therapy intends to protect and prevail the vitality of pulp tissue which gets compromised when subjected to mutilating factors like dental caries, trauma, and operative or restorative procedures. During the therapy, the said bioactive material initially forms a non-irritant protective bridge over the vital pulp and later stimulates the pulpal odontoblasts to produce a reparative dentinal barrier which later forms a barrier and protects the underlying pulp’s vitality. The vitality of a tooth needs to be intact protected because the consensus reports that endodontically treated teeth, particularly molars, reportedly have a reduced survival probability than the vital teeth. [1] These factual arguments lead to the development of biologically active restorative materials. This review article intends to provide a review of the modern products introduced in the category of bioactive restorative materials.
Downloads
References
About I. Biodentine: from biochemical and bioactive properties to clinical applications. Giornale Italiano di Endodonzia. 2016;30(2):81-8.
Adl A, Javanmardi S, Abbaszadegan A. Assessment of tooth discoloration induced by biodentine and white mineral trioxide aggregate in the presence of blood. Journal of Conservative Dentistry: JCD. 2019;22(2):164.
Aguilar P, Linsuwanont P. Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod. 2011;37(5):581-7.
Al-Dlaigan YH. Pulpotomy medicaments used in deciduous dentition: an Update. J Contemp Dent Pract. 2015;16(6):486-503.
Alqaderi H, Lee CT, Borzangy S, Pagonis TC. Coronal pulpotomy for cariously exposed permanent posterior teeth with closed apices: A systematic review and meta-analysis. J Dent. 2016;44:1-7.
Arandi NZ, Thabet M. Minimal Intervention in Dentistry: A Literature Review on Biodentine as a Bioactive Pulp Capping Material. BioMed research international. 2021;2021.
Bajrami D, Stavileci M, Dragidella A, Sejfija Z. In Vitro Antifungal Effect of Biodentine™ Against Candida Albicans. Journal of International Dental and Medical Research. 2020;13(1):57-60.
Bergenholtz G, Axelsson S, Davidson T, Frisk F, Hakeberg M, Kvist T, et al. Treatment of pulps in teeth affected by deep caries–A systematic review of the literature. Singapore Dental Journal. 2013;34(1):1-12.
Cao CY, Mei ML, Li Q-L, Lo ECM, Chu CH. Methods for biomimetic remineralization of human dentine: a systematic review. International journal of molecular sciences. 2015;16(3):4615-27.
Caplan DJ, Cai J, Yin G, White BA. Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times. J Public Health Dent. 2005;65(2):90-6.
Castro-Raucci LMSd, Oliveira IRd, Teixeira LN, Rosa AL, Oliveira PTd, Jacobovitz M. Effects of a novel calcium aluminate cement on the early events of the progression of osteogenic cell cultures. Brazilian Dental Journal. 2011;22:99-104.
Chailertvanitkul P, Paphangkorakit J, Sooksantisakoonchai N, Pumas N, Pairojamornyoot W, Leela-apiradee N, et al. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. International Endodontic Journal. 2014;47(9):835-42.
Cox C, Sübay R, Ostro E, Suzuki S, Suzuki S. Tunnel defects in dentin bridges: their formation following direct pulp capping. Operative dentistry. 1996;21(1):4-11.
Cox CF, Suzuki S. Re-evaluating pulp protection: calcium hydroxide liners vs. cohesive hybridization. The Journal of the American Dental Association. 1994;125(7):823-31.
Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, et al. Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review. J Dent. 2019;88:103158.
Darade L, Ranjan S, Singh GB, Gangadhar B, Vandekar M, Rathi AG. Bioceramic a futuristic boon in endodontics-A.
Deepa V, Dhamaraju B, Bollu I, Balaji T. Shear bond strength evaluation of resin composite bonded to three different liners: TheraCal LC, Biodentine, and resin-modified glass ionomer cement using universal adhesive: An in vitro study. Journal of Conservative Dentistry. 2016;19(2):166-70.
Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, et al. European Society of Endodontology position statement: Management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):923-34.
Elmsmari F, Ruiz XF, Miró Q, Feijoo-Pato N, Durán-Sindreu F, Olivieri JG. Outcome of Partial Pulpotomy in Cariously Exposed Posterior Permanent Teeth: A Systematic Review and Meta-analysis. J Endod. 2019;45(11):1296-306.e3.
Eren SK, Örs SA, Aksel H, Canay Ş, Karasan D. Effect of irrigants on the color stability, solubility, and surface characteristics of calcium-silicate based cements. Restorative Dentistry & Endodontics. 2022;47(1).
Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects. Cochrane database of systematic reviews. 2009(4).
Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects. The Cochrane database of systematic reviews. 2009;2009(4):Cd003875.
Estrela C, Sydney GB, Bammann LL, Felippe Júnior O. Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. Brazilian dental journal. 1995;6(2):85-90.
Gandolfi M, Siboni F, Prati C. Chemical–physical properties of TheraCal, a novel light‐curable MTA‐like material for pulp capping. International endodontic journal. 2012;45(6):571-9.
Garcia LdFR, Huck C, de Oliveira LM, de Souza PPC, de Souza Costa CA. Biocompatibility of new calcium aluminate cement: tissue reaction and expression of inflammatory mediators and cytokines. Journal of Endodontics. 2014;40(12):2024-9.
Ghoddusi J, Forghani M, Parisay I. New approaches in vital pulp therapy in permanent teeth. Iranian endodontic journal. 2014;9(1):15.
Ghoddusi J, Forghani M, Parisay I. New approaches in vital pulp therapy in permanent teeth. Iran Endod J. 2014;9(1):15-22.
Hanna SN, Perez Alfayate R, Prichard J. Vital Pulp Therapy an Insight Over the Available Literature and Future Expectations. Eur Endod J. 2020;5(1):46-53.
Hirschman WR, Wheater MA, Bringas JS, Hoen MM. Cytotoxicity comparison of three current direct pulp-capping agents with a new bioceramic root repair putty. Journal of Endodontics. 2012;38(3):385-8.
Jacobovitz M, Vianna ME, Pandolfelli VC, Oliveira IR, Rossetto HL, Gomes BP. Root canal filling with cements based on mineral aggregates: an in vitro analysis of bacterial microleakage. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009;108(1):140-4.
Jefferies SR. Bioactive and biomimetic restorative materials: a comprehensive review. Part I. Journal of esthetic and restorative dentistry. 2014;26(1):14-26.
Johari Y, Pungut NA, Yin VWX, Khamis MF, Yusoff MNM. Sealing Ability of Injectable Dental Composites, Biodentine and MTA in Repairing Furcal Perforation of Permanent Molar Teeth. Journal of International Dental and Medical Research. 2020;13(4):1428-34.
Kadali NS, Alla RK, AV R, MC SS, Mantena SR, RV R. An overview of composition, properties, and applications of Biodentine. International Journal of Dental Materials. 2021;3(4):120-6.
Kaur M, Singh H, Dhillon JS, Batra M, Saini M. MTA versus Biodentine: review of literature with a comparative analysis. Journal of clinical and diagnostic research: JCDR. 2017;11(8):ZG01.
Khedmat S, Ahmadi E, Meraji N, Fallah ZF. Colorimetric Comparison of Internal Bleaching with and without Removing Mineral Trioxide Aggregate (MTA) on Induced Coronal Tooth Discoloration by MTA. International Journal of Dentistry. 2021;2021.
Kim JR, Nosrat A, Fouad AF. Interfacial characteristics of Biodentine and MTA with dentine in simulated body fluid. Journal of dentistry. 2015;43(2):241-7.
Komabayashi T, Zhu Q, Eberhart R, Imai Y. Current status of direct pulp-capping materials for permanent teeth. Dental materials journal. 2016;35(1):1-12.
Koubi G, Colon P, Franquin J-C, Hartmann A, Richard G, Faure M-O, et al. Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth—a prospective study. Clinical oral investigations. 2013;17(1):243-9.
Kunert M, Lukomska-Szymanska M. Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article. Materials. 2020;13(5):1204.
Li Z, Cao L, Fan M, Xu Q. Direct Pulp Capping with Calcium Hydroxide or Mineral Trioxide Aggregate: A Meta-analysis. J Endod. 2015;41(9):1412-7.
Lim M, Song M, Hong C-U, Cho Y-b. The biocompatibility and mineralization potential of mineral trioxide aggregate containing calcium fluoride–An in vitro study. Journal of Dental Sciences. 2021;16(4):1080-6.
Lin LM, Ricucci D, Saoud TM, Sigurdsson A, Kahler B. Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. Australian Endodontic Journal. 2020;46(1):154-66.
Lovato KF, Sedgley CM. Antibacterial activity of endosequence root repair material and proroot MTA against clinical isolates of Enterococcus faecalis. Journal of endodontics. 2011;37(11):1542-6.
Madani Z, Alvandifar S, Bizhani A. Evaluation of tooth discoloration after treatment with mineral trioxide aggregate, calcium-enriched mixture, and Biodentine® in the presence and absence of blood. Dental Research Journal. 2019;16(6):377.
Malkondu Ö, Kazandağ MK, Kazazoğlu E. A review on biodentine, a contemporary dentine replacement and repair material. BioMed research international. 2014;2014.
Marques Junior RB, Baroudi K, Santos AFCd, Pontes D, Amaral M. Tooth discoloration using calcium silicate-based cements for simulated revascularization in vitro. Brazilian Dental Journal. 2021;32:53-8.
Megantoro A, Djauharie RN, Margono A. The Effect of BiodentineTM Application in Affected Dentin Remineralization after Partial Caries Excavation In Vivo. Journal of International Dental and Medical Research. 2019;12(3):1117-22.
Mente J, Hufnagel S, Leo M, Michel A, Gehrig H, Panagidis D, et al. Treatment outcome of mineral trioxide aggregate or calcium hydroxide direct pulp capping: long-term results. Journal of Endodontics. 2014;40(11):1746-51.
Meraji N, Camilleri J. Bonding over dentin replacement materials. Journal of endodontics. 2017;43(8):1343-9.
Mutluay M, Mutluay AT. Sealing efficiency of MTA, accelerated MTA, Biodentine and RMGIC as retrograde filling materials. Balkan Journal of Dental Medicine. 2021;25(3):159-65.
Nair PN, Duncan HF, Pitt Ford TR, Luder HU. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with Mineral Trioxide Aggregate: a randomized controlled trial. 2008. Int Endod J. 2009;42(5):422-44.
Ochoa-Rodríguez VM, Tanomaru-Filho M, Rodrigues EM, Guerreiro-Tanomaru JM, Spin-Neto R, Faria G. Addition of zirconium oxide to Biodentine increases radiopacity and does not alter its physicochemical and biological properties. Journal of applied oral science. 2019;27.
Okiji T, Yoshiba K. Reparative dentinogenesis induced by mineral trioxide aggregate: a review from the biological and physicochemical points of view. International journal of dentistry. 2009;2009.
Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review—part III: clinical applications, drawbacks, and mechanism of action. Journal of endodontics. 2010;36(3):400-13.
Pereira TC, da Silva Munhoz Vasconcelos LR, Graeff MSZ, Ribeiro MCM, Duarte MAH, de Andrade FB. Intratubular decontamination ability and physicochemical properties of calcium hydroxide pastes. Clinical oral investigations. 2019;23(3):1253-62.
Pires MD, Cordeiro J, Vasconcelos I, Alves M, Quaresma SA, Ginjeira A, et al. Effect of different manipulations on the physical, chemical and microstructural characteristics of Biodentine. Dental Materials. 2021;37(7):e399-e406.
Prati C, Gandolfi MG. Calcium silicate bioactive cements: Biological perspectives and clinical applications. Dental materials. 2015;31(4):351-70.
Qureshi A, Soujanya E, Nandakumar P. Recent advances in pulp capping materials: an overview. Journal of clinical and diagnostic research: JCDR. 2014;8(1):316.
Rajasekharan S, Martens L, Cauwels R, Anthonappa RP. Biodentine™ material characteristics and clinical applications: a 3 year literature review and update. European Archives of Paediatric Dentistry. 2018;19(1):1-22.
Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. Effect of biomaterials on angiogenesis during vital pulp therapy. Dental materials journal. 2016:2015-332.
Schröder U. Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. Journal of dental research. 1985;64(4):541-8.
Schwendicke F, Frencken JE, Bjørndal L, Maltz M, Manton DJ, Ricketts D, et al. Managing carious lesions: consensus recommendations on carious tissue removal. Advances in dental research. 2016;28(2):58-67.
Shokouhinejad N, Alikhasi M, Khoshkhounejad M, Pirmoazen A. Effect of irrigation solutions on the coronal discoloration induced by mineral trioxide aggregate cements containing different radiopacifiers. Dental Research Journal. 2020;17(6):447.
Silva EJ, Herrera DR, Rosa TP, Duque TM, Jacinto RC, Gomes BP, et al. Evaluation of cytotoxicity, antimicrobial activity and physicochemical properties of a calcium aluminate-based endodontic material. Journal of applied oral science : revista FOB. 2014;22(1):61-7.
Simon S, Smith AJ, Lumley PJ, Cooper PR, Berdal A. The pulp healing process: from generation to regeneration. Endodontic Topics. 2012;26(1):41-56.
Slaboseviciute M, Vasiliauskaite N, Drukteinis S, Martens L, Rajasekharan S. Discoloration Potential of Biodentine: A Systematic Review. Materials. 2021;14(22):6861.
Spagnuolo G. Bioactive Dental Materials: The Current Status. Materials. 2022;15(6):2016.
Srinivasan S, Vengidesh R, Ramachandran A, Kadandale S. An Immature Traumatic Teeth Management With Apical Pathology Using the Novel Biodentine™ Obturation: A Case Report. Cureus. 2021;13(12).
Stencel R, Kasperski J, Pakieła W, Mertas A, Bobela E, Barszczewska-Rybarek I, et al. Properties of experimental dental composites containing antibacterial silver-releasing filler. Materials. 2018;11(6):1031.
Tamzini M, Albeshti R, Abdesalam A. Enamel Matrix Derivative (Emdogain®) for Wound Healing and Bone Regeneration: A Short-Review. Libyan J Med Res. 2022;16(1):107-13.
Tan SY, Yu VSH, Lim KC, Tan BCK, Neo CLJ, Shen L, et al. Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth. Journal of endodontics. 2020;46(3):383-90.
Tripathi R, Cohen S, Khanduri N. Coronal tooth discoloration after the use of white mineral trioxide aggregate. Clinical, Cosmetic and Investigational Dentistry. 2020;12:409.
Vural UK, Kiremitci A, GÖKALP S. Which is the most effective biomaterial in indirect pulp capping? 4-year comparative randomized clinical trial. European Oral Research. 2022;56(1):35-41.
Widbiller M, Jeanneau C, Galler KM, Laurent P. Biocompatibility and Bioactive Properties of Biodentine TM. Biodentine™: Springer; 2022. p. 31-50.
Xu D, Mutoh N, Ohshima H, Tani-Ishii N. The effect of mineral trioxide aggregate on dental pulp healing in the infected pulp by direct pulp capping. Dental Materials Journal. 2021;40(6):1373-9.
Zhu C, Ju B, Ni R. Clinical outcome of direct pulp capping with MTA or calcium hydroxide: a systematic review and meta-analysis. International journal of clinical and experimental medicine. 2015;8(10):17055.
박윤정, 강주희, 서현, 송호준, 박영준, 저자. Effect of compositional variation of dental MTA cements on setting time. Korean Journal of Dental Materials-Vol. 2021;48(2):99-118.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
