A study on success of methotrexate in single or two doses for medical management of ectopic pregnancy

Savitha Keranahalli Basanna; Prema Prabhudev

doi:10.53730/ijhs.v6nS8.13554

A study on success of methotrexate in single or two doses for medical management of ectopic pregnancy

https://doi.org/10.53730/ijhs.v6nS8.13554

Authors

Savitha Keranahalli Basanna Associate Professor, Department of Obstetrics and Gynecology, SS Medical College and Research Center Davangere Karnataka
Prema Prabhudev Professor, Department of Obstetrics and Gynecology, SS Medical College and Research Center Davangere Karnataka

Keywords:

methotrexate, ectopic pregnancy, failure, beta hCG, ectopic mass diameter

Abstract

Background: The treatment of ectopic pregnancy in conservative manner in order to preserve the subsequent fertility is important. Methotrexate can be effectively used in termination of ectopic pregnancy. This study compares the single dose versus double dose approach for the conservative management of pregnancy. Material and Methods: A prospective study was conducted in a tertiary care centre. About 70 women with ectopic pregnancy were administered with single or double dose of methotrexate were followed up. The second dose of MTX was administered when there was no 15% decrease in β-hCG levels between day 4 and 7. The data thus obtained was compiled and analysed. Results: The mean age was comparable in single and double dose groups. The mean gestational age in single dose group was 7.1 weeks and double dose group was 7.48 weeks. The termination of ectopic pregnancy was successful in 80.8% of the single and 33.3% of the two dose groups. The mean EP diameter in single dose group was 24.03 and double dose group was 33.7 mms. The length of stay was significantly lower in double dose groups. Conclusion: The single dose protocol of methotrexate was superior when compared with the double dose protocol.

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References

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Published

27-12-2021

How to Cite

Basanna, S. K., & Prabhudev, P. (2021). A study on success of methotrexate in single or two doses for medical management of ectopic pregnancy. International Journal of Health Sciences, 6(S8), 5617–5622. https://doi.org/10.53730/ijhs.v6nS8.13554

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Issue

Vol. 6 No. S8 (2022)

Section

Peer Review Articles

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