Cost variation analysis of various non-steroidal anti-inflammatory drugs available in the Indian market

D R Veena; M Sahana; S Jagdish; A V Sareetha; P Shanmukananda

doi:10.53730/ijhs.v6nS8.13563

Authors

Veena D R Associate Professor, Department of Pharmacology, Dr B R Ambedkar Medical College, Bangalore
Sahana M Assistant Professor, Department of Pharmacology, Dr B R Ambedkar Medical College, Bangalore
Jagdish S Professor and Head, Department of Preventive and Social Medicine, Dr B R Ambedkar Medical College, Bangalore
Sareetha A V
dr.sarithaav@gmail.com
Assistant professor, Department of Pharmacology, Dr B R Ambedkar Medical College, Bangalore
Shanmukananda P Professor and Head, Department of Pharmacology, Dr B R Ambedkar Medical College, Bangalore

Keywords:

cost variation analysis, non steroidal anti inflammatory drugs, generic drugs

Abstract

Background: Non Steroidal Anti Inflammatory Drugs (NSAIDS) are used to treat a variety of conditions associated with pain and inflammation. Analysis of price variation among different brands of NSAIDS provides a guide for cost - effective prescribing and helps to reduce the financial burden on the patient and improves patient compliance. Aim: To analyze price variation of various single NSAID’s formulations available in the Indian market. Material & Methods: Price of NSAIDs manufactured by different pharmaceutical companies in India of same strength was obtained from Current Index of Medical Specialties, January-March 2022. Difference between maximum and minimum price of the same formulation, cost ratio and percentage cost variation was calculated. Results: Large price variation was seen with Celecoxib 100mg capsule (476.6%) followed by Celecoxib 200mg capsule (402.3%),Nimesulide 100mg tablet (358.33%) and Paracetamol 500mg tablet (285.06).Price variation was lowest for Mefenamic acid 250mg tablet (8%). Among the syrup formulations, it was seen that there was a price variation of 29.5% for Paracetamol 125mg/5ml, 54.15% for Ibuprofen 100mg/5ml and 37.1% for Mefenamic acid 100mg/5ml. Among the injectable NSAID’s, price variation was maximum for Diclofenac 75mg/ml (441.39%). Diclofenac 1%w/w 30gm gel showed price variation of 264.86% among the topical NSAID’s.

Downloads

Download data is not yet available.

References

Biswas R, Chatterjee P, Mundle M. Prescribing habits of physicians in medical college, Calcutta. Indian J Community Med 2000;25:161-5. Kesselheim AS, MR, Brookhart MA, Choudhry NK,

Brune K, Hinz B. The discovery and development of anti-inflammatory drugs. Arthritis Rheum 2004;50:2391-9.

Chawan VS, Gawand KV, Badwane SV. Cost analysis of oral hypolipidemic agents available in India. Int J Basic Clin Pharmacol 2014;3:954-7.

Drug Price Control Order 2013.Retrieved from http://www.nppaindia.nic.in/ DPCO2013.pdf .

Gupta K, Vishwe A, Patel P, Malani R, Nyati P, Tripathi S. Cost variation analysis of nonsteroidal anti-inflammatory drugs available as single formulation in the Indian market. Natl J Physiol Pharm Pharmacol 2021;11(07):745-750.

Kesselheim AS, MR, Brookhart MA, Choudhry NK, Shrank WH. Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: A systematic review and meta-analysis. JAMA 2008;300:2514-26.

King DR, Kanavos P. Encouraging the use of generic medicines: Implications for transition economies. Croat Med J 2002;43:462-9.

Medical Council of India. Indian Medical Council (Professional Conduct, Etiquette, Ethics) Regulations 2002. New Delhi: Medical Council of India; 2002. Retrieved from: http://www.mciindia.org/rulesandregulations/codeofmedical ethicsregulations2002.

National List of Essential Medicines 2015. Retrieved from http://cdsco.nic.in/WriteReadData/NLEM-2015/NLEM,%202015.pdf.

Patel BS, Chavda FM and Mundhava SG: Cost Variation Analysis of Single Nonsteroidal Anti-Inflammatory Agents Available In Indian Market: An Economic Perspective. Int J Pharm Sci Res 2016; 7(5): 2174-80

Suryaprakash D. Rational drug therapy. J Rational Pharmacother Res 2014;2:67-72.

Suzanne SD, Colum PD. What do people really think of generic medicines? A systematic review and critical appraisal of literature on stakeholder perceptions of generic drugs.BMC Med 2015;13:173.

Tilyard MW, Dovey SM, Rosentstreich D. General practitioners’ views on generic medication and substitution. N Z Med J 1990;103:318-20.

Vaishnavi PR, Gaikwad N, Dhaneria SP. Assessment of nonsteroidal anti-inflammatory drug use pattern using World Health Organization indicators: A cross-sectional study in a tertiary care teaching hospital of Chhattisgarh. Indian J Pharmacol 2017;49:445-50.