Comparison of efficacy between two doses of dexamethasone as an intratympanic injection in Idiopathic Sudden Sensorineural Hearing Loss
Keywords:
dexamethasone, intratympanic injection, idiopathic, Sudden Sensorineural Hearing LossAbstract
Introduction: Most cases of sudden sensorineural hearing loss (SSHL) are idiopathic, so there is no specific treatment protocol for this set of patients, which is accepted worldwide. Some temporal bone studies regarding histopathological findings in SSHL cases found that most of the lesions were in the cochlea and its structures. The histological findings suggest that some inflammatory, vascular or immunological aetiology are present behind such lesions in cochlea. Inflammation being one of the major among all the aetiologies, so steroids are the mainstay of treatment for Idiopathic sudden sensorineural hearing loss (ISSHL) cases. Material and methods: A prospective comparative study was done on 56 patients aged 18 to 70 years. Patients received 4mg/ml dose (Arm A) or 8mg/ml dose (Arm B) ofintratympanic dexamethasone injection. The targeted recovery on 5th day after 1st intratympanic steroid injection was compared with baseline Pure tone Audiometry (PTA)of day 1 for both the groups. Statistical analysis: More than 20db improvement in PTA average (0.5K,1k and 2k) onassessment at 5th day after 1stinjection was considered as recovery criteria. A comparison was done on improvement between two arms.
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