Assessment of anti-nociceptive and anti-inflammatory potentials of Dracaena Reflexa leaves
Keywords:
Dracaena reflexa, anti-inflammatory, antinociceptive, writhing responses, acetic acid, acute toxicity, reaction timeAbstract
Dracaena reflexa (family: Asparagaceae), commonly known as Song of India is a tropical plant that is traditionally claimed to have high medicinal values. The current exploration was intended to assess the pain-relieving and anti-inflammatory potentials of methanolic extract of Dracaena reflexa (MEDR) leaves in rodents. Acute oral toxicity studies were performed for the MEDR as per OECD guidelines 423. Anti-inflammatory action was assessed by the carrageenan incited paw edema method. The anti-nociceptive effect was explored by using acetic acid incited writhing responses, tail immersion, and hot plate technique in rodents. Acute oral toxicity investigation for 14 days reveals the safety of MEDR with no mortality at 2000 mg/kg. Hence 200 & 400 mg/kg was selected for in vivo studies. MEDR at both doses exhibited significant anti-inflammatory action by diminishing paw volume (ml) (0.29±0.016, 0.17±0.014) when compared to control (1.71±0.015) at the 4th hour of the study. Acetic acid incited writhing technique indicates the anti-nociceptive effect as the number of writhing responses with leaf extract significantly decreased (12.33±0.57) in comparison to control rats (27.33±1.52).
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