Prevalence of bacterial co infections among Covid 19 patients in wasit province
Keywords:
Covid19, bacterial coinfection, IraqAbstract
Background : The pandemic of severe acute respiratory syndrome coronavirus 2 raised the attention towards bacterial co-infection and its role in coronavirus disease 2019 (COVID-19) disease. This study aims to review and identify the prevalence of bacterial co-infection in Iraqi patients as bacterial co-infection played an important role in escalating the morbidity and mortality rate during previous viral outbreaks and pandemics of COVID-19. Materials and Methods: It was collected three hundred eighty clinical samples from covid-19 patients, in Iraqi patients from a period between November 2021 to January 2021, in the bacteriology Unit. Each specimen was cultured on Blood agar, MacConkey agar, Mannitol Salt Agar and Chocolate Agar plates to be isolated, then samples was identified using biochemical test. Result: According to morphological and biochemical tests among collected samples 80 (21.1%) were positive samples, while 300 (78.9%) were negative samples, positive samples included 61(76.2%) gram negative (Gr -ve) and 19 (23.8%) were gram positive (Gr +ve), positive samples were distributed as following, 50 (62.5%) samples K. pneumonia, 3 (3.8%) Pseudomonas aeruginosa, 5 (6.2%) Acinetobacter baumanii, 4 (5%) Micrococcus, 12 (15%) Staphylococcus aureus, 3 (3.8%) Enterococcus cloacae and 3 (3.8%) were Aerococcus viridans.
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Bashir A, Abdullah MS, Momin NR, Chong PL, Asli R, Ivan BM, et al. Prevalence of primary bacterial co-infections among patients with COVID-19 in Brunei Darussalam. Western Pacific Surveillance and Response Journal: WPSAR. 2021;12(3):65.
Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M. The 2019‐new coronavirus epidemic: evidence for virus evolution. Journal of medical virology. 2020;92(4):455-9.
Tada A, Senpuku H. The impact of oral health on respiratory viral infection. Dentistry Journal. 2021;9(4):43.
Mirzaei R, Goodarzi P, Asadi M, Soltani A, Aljanabi HAA, Jeda AS, et al. Bacterial co‐infections with SARS‐CoV‐2. IUBMB life. 2020;72(10):2097-111.
Guo L, Wei D, Zhang X, Wu Y, Li Q, Zhou M, et al. Clinical features predicting mortality risk in patients with viral pneumonia: the MuLBSTA score. Frontiers in microbiology. 2019;10:2752.
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama. 2020;323(13):1239-42.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet. 2020;395(10229):1054-62.
Vatopoulos A, Kalapothaki V, Legakis N. An electronic network for the surveillance of antimicrobial resistance in bacterial nosocomial isolates in Greece. The Greek Network for the Surveillance of Antimicrobial Resistance. Bulletin of the World Health Organization. 1999;77(7):595.
Smith AM, McCullers JA. Secondary bacterial infections in influenza virus infection pathogenesis. Influenza Pathogenesis and Control-Volume I. 2014:327-56.
Mulcahy ME, McLoughlin RM. Staphylococcus aureus and influenza a virus: partners in coinfection. MBio. 2016;7(6):e02068-16.
McFee R. COVID-19 laboratory testing/CDC guidelines. Disease-a-Month. 2020;66(9):101067.
Saini V, Jain C, Singh NP, Alsulimani A, Gupta C, Dar SA, et al. Paradigm shift in antimicrobial resistance pattern of bacterial isolates during the COVID-19 pandemic. Antibiotics. 2021;10(8):954.
Ahmed Hasan S, T Raheem F, Mohammed Abdulla H. Phenotypic, Antibiotyping, and Molecular Detection of Klebsiella Pneumoniae Isolates from Clinical Specimens in Kirkuk, Iraq. Archives of Razi Institute. 2021;76(4):1061-7.
Kadum SM. Colistin Susceptibility in Carbapenem Resistant Klebsiella Pneumoniae and their Ability of Biofilm Formation. Iraqi Journal of Science. 2020:517-27.
Namratha K, Sreeshma P, Subbannayya K, Dinesh P, Champa H. Characterization and antibiogram of Klebsiella spp. isolated from clinical specimen in a rural teaching hospital. Scholars Journal of Applied Medical Sciences. 2015;3(2E):878-83.
Nirwati H, Sinanjung K, Fahrunissa F, Wijaya F, Napitupulu S, Hati VP, et al., editors. Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia. BMC proceedings; 2019: BioMed Central.
Al-Rubaye DS, Hamza HM, Abdulrahman TR. Genotyping of Klebsiella spp. isolated from different clinical sources. Iraqi Journal of Science. 2016:1937-51.
Gomathi A. A Study on Blood Stream Infections in Intensive Care Units of Tertiary Care Hospital: Madras Medical College, Chennai; 2020.
Vaneci-Silva D, Assane IM, de Oliveira Alves L, Gomes FC, Moro EB, Kotzent S, et al. Klebsiella pneumoniae causing mass mortality in juvenile Nile tilapia in Brazil: Isolation, characterization, pathogenicity and phylogenetic relationship with other environmental and pathogenic strains from livestock and human sources. Aquaculture. 2022;546:737376.
kumar Arya L, Kumar M, Priya P, Saurabh K, Kumari N. Isolation and identification of Klebsiella pneumoniae from a milk sample. Indian Vet J. 2020;97(01):15-7.
Morales Barrios SD, Tovar Oviedo J. Presentation: Biochemical tests and antimicrobial susceptibility with Klebsiella oxytoca. 2017.
Bott M, Meyer M, Dimroth P. Regulation of anaerobic citrate metabolism in Klebsiella pneumoniae. Molecular microbiology. 1995;18(3):533-46.
Alves MS, Dias RCdS, de Castro ACD, Riley LW, Moreira BM. Identification of clinical isolates of indole-positive and indole-negative Klebsiella spp. Journal of clinical microbiology. 2006;44(10):3640-6.
Rahman J. Screening for silver resistant silE gene in Klebsiella pneumoniae isolated from wound and burn patients: BRAC Univeristy; 2017.
Ali AM, Sana’a N. Virulence factors genotyping of Klebsiella pneumoniae clinical isolates from Baghdad. Reviews in Medical Microbiology. 2019;30(1):36-46.
Guzek A, Rybicki Z, Woźniak-Kosek A, Tomaszewski D. The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with Klebsiella pneumoniae NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study. Diagnostics. 2022;12(5):1118.
Arcari G, Raponi G, Sacco F, Bibbolino G, Di Lella FM, Alessandri F, et al. Klebsiella pneumoniae infections in COVID-19 patients: a 2-month retrospective analysis in an Italian hospital. International Journal of Antimicrobial Agents. 2021;57(1):106245.
Alqahtani A, Alamer E, Mir M, Alasmari A, Alshahrani MM, Asiri M, et al. Bacterial Coinfections Increase Mortality of Severely Ill COVID-19 Patients in Saudi Arabia. International Journal of Environmental Research and Public Health. 2022;19(4):2424.
Stefanini I, De Renzi G, Foddai E, Cordani E, Mognetti B. Profile of bacterial infections in COVID-19 patients: antimicrobial resistance in the time of SARS-CoV-2. Biology. 2021;10(9):822.
Harding CM, Hennon SW, Feldman MF. Uncovering the mechanisms of Acinetobacter baumannii virulence. Nature Reviews Microbiology. 2018;16(2):91-102.
Dergaa I, Abubaker M, Souissi A, Mohammed AR, Varma A, Musa S, et al. Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value. Libyan Journal of Medicine. 2022;17(1):2010337.
Esme M, Topeli A, Yavuz BB, Akova M. Infections in the elderly critically-ill patients. Frontiers in medicine. 2019;6:118.
Kim B, Kim K, Yoon Js. Nosocomial Acinetobacter baumannii infection in children in adult versus pediatric intensive care units. Pediatrics International. 2020;62(4):451-8.
Swarcwald CL, Mateos SdOG, Leon ACMPd, Medronho RdA, Veloso VG, Lopes JIF, et al. Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil. 2020.
Stringhini S, Wisniak A, Piumatti G, Azman AS, Lauer SA, Baysson H, et al. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study. The Lancet. 2020;396(10247):313-9.
Papadopoulos V, Li L, Samplaski M. Why does COVID‐19 kill more elderly men than women? Is there a role for testosterone? Andrology. 2021;9(1):65-72.
Li Lq, Huang T, Wang Yq, Wang Zp, Liang Y, Huang Tb, et al. COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis. Journal of medical virology. 2020;92(6):577-83.
Marconi VC, Ramanan AV, de Bono S, Kartman CE, Krishnan V, Liao R, et al. Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial. The Lancet Respiratory Medicine. 2021;9(12):1407-18.
Cai H. Sex difference and smoking predisposition in patients with COVID-19. The Lancet Respiratory Medicine. 2020;8(4):e20.
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