Nutrition and addiction - are they linked in de-addictive process? A review

K S Rashmi; Liegelin Kavitha; Poulomi Chatterjee; Aparna Tripathy; Ashwin R Rai; Pratik Kumar Chatterjee

doi:10.53730/ijhs.v6nS8.13797

Authors

Rashmi K S Associate-Professor, Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India
Liegelin Kavitha Associate-Professor, Division of Physiology, Department of Basic Sciences, Manipal Academy of Higher Education, Manipal, India
Poulomi Chatterjee Ph.D. Scholar, Department of Community Medicine, Yenepoya Medical College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India
Aparna Tripathy Research Associate, Division of Physiology, Department of Basic Sciences, Manipal Academy of Higher Education, Manipal, India
Ashwin R Rai Associate-Professor, Department of Anatomy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India
Pratik Kumar Chatterjee
pratik.chatterjee@manipal.edu
Associate-Professor, Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Keywords:

addiction, lifestyle, nutrition, reward system, recreational substances

Abstract

Background: Substance abuse has become a serious issue that is faced by the world. The effects of drug abuse can be detrimental to corporeal, psychological and societal well-being of a person. Drug misuse is actually unrestrained habit of drugs leading to inspiration of reward-system in brain Substance abuse also influences the food preferences and dietary habits of the users, therefore affecting the person’s nutrition. Instead of how frequently a person engages in the behavior, substance abuse and substance addiction are distinguished by how challenging it is for the person to manage without the behavior or quit it for a specific period of time. Methodology: Electronic databases were used to conduct a thorough, systematic analysis of research, which was restricted to those with English/English abstracts and used words like "addiction," "nutrition," "lifestyle," "alcohol," "reward system," "recreational substances," etc., Conclusion: An effort has been made in this research article to highlight the effects of various addictive substances on different systems in human body with the role of adequate nutrition to fight back this addiction for the overall betterment of the society.

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References

Acharya, C., Betrapally, N. S., Gillevet, P. M., Sterling, R. K., Akbarali, H., White, M. B., ... & Bajaj, J. (2017). Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis. Alimentary pharmacology & therapeutics, 45(2), 319-331.

Agrawal, A., & Lynskey, M. T. (2008). Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction, 103(7), 1069-1081.

Alves, D., Costa, A. F., Custódio, D., Natário, L., Ferro-Lebres, V., & Andrade, F. (2011). Housing and employment situation, body mass index and dietary habits of heroin addicts in methadone maintenance treatment. Heroin Addict Relat Clin Probl, (1), 11-14.

Angeles-Agdeppa, I., Arias, F. P. S., Sy, J. A. J. P., & Garingo, R. A. P. (2021). Nutrition Care Processes Can Improve the Nutritional Status and Quality of Life of Persons Who Use Drugs. International Journal of High Risk Behaviors and Addiction, 10(4).

Anywar, G., Kakudidi, E., Tugume, P., & Asiimwe, S. (2022). The Cannabis/Marijuana (L.) Landscape in Africa: An Overview of its Cultivation and Legal Aspects. Cannabis/Hemp for Sustainable Agriculture and Materials, 297-310.

Azod, L., Rashidi, M., Afkhami-Ardekani, M., Kiani, G., & Khoshkam, F. (2008). Effect of opium addiction on diabetes. The American journal of drug and alcohol abuse, 34(4), 383-388.

Belackova, V. (2020). “The Good, the Bad, and the Ugly Weed”: How Consumers in Four Different Policy Settings Define the Quality of Illicit Cannabis. Contemporary Drug Problems, 47(1), 43-62.

Billing, L., & Ersche, K. D. (2015). Cocaine’s appetite for fat and the consequences on body weight. The American journal of drug and alcohol abuse, 41(2), 115-118.

Blanco-Gandía, M. C., & Rodríguez-Arias, M. (2017). Bingeing on fat increases cocaine reward. Oncotarget, 8(10), 16105.

Bode, C., & Bode, J. C. (2003). Effect of alcohol consumption on the gut. Best practice & research Clinical gastroenterology, 17(4), 575-592.

Buydens-Branchey, L., & Branchey, M. (2003). Association between low plasma levels of cholesterol and relapse in cocaine addicts. Psychosomatic medicine, 65(1), 86-91.

Carey, M., Gospin, R., Goyal, A., Tomuta, N., Sandu, O., Mbanya, A.,& Hawkins, M. (2017). Opioid receptor activation impairs hypoglycemic counterregulation in humans. Diabetes, 66(11), 2764-2773.

Carson, R. E. (2012). The Brain Fix: What's the Matter with Your Gray Matter: Improve Your Memory, Moods, and Mind. Health Communications, Inc..

Challier, B., Chau, N., Prédine, R., Choquet, M., & Legras, B. (2000). Associations of family environment and individual factors with tobacco, alcohol and illicit drug use in adolescents. European Journal of epidemiology, 16(1), 33-42.

Clasen, M. M., Sanon, T. V., Hempel, B. J., Nelson, K. H., Kearns, D. N., Davidson, T. L., & Riley, A. L. (2020). Ad-libitum high fat diet consumption during adolescence and adulthood impacts the intravenous self-administration of cocaine in male Sprague-Dawley rats. Experimental and clinical psychopharmacology, 28(1), 32.

Coller, J. K., & Hutchinson, M. R. (2012). Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & therapeutics, 134(2), 219-245.

Cowan, J., & Devine, C. (2008). Food, eating, and weight concerns of men in recovery from substance addiction. Appetite, 50(1), 33-42.

CPE Monthly: Substance Abuse and Nutrition by Alyssa Salz, MS, RD, LD.

Dhawan, B. N. (1996). International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev., 48, 567-592.

Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C.,& Lecca, D. (2004). Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology, 47, 227-241.

Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., & Kunos, G. (2001). Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature, 410(6830), 822-825.

Díaz-Flores, J. F., Sañudo, R. I., Rodríguez, E. M., & Romero, C. D. (2004). Serum concentrations of macro and trace elements in heroin addicts of the Canary Islands. Journal of Trace Elements in Medicine and Biology, 17(4), 235-242.

Eisenstein, E., Aquino, M. T., Caldeira, Z., Freire, Z., & Baptista, M. (2005). Youth and drugs in Brazil: social imbalance and health risks. Substance use among young people in urban environments, 121-132.

Ersche, K. D., Stochl, J., Woodward, J. M., & Fletcher, P. C. (2013). The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men. Appetite, 71, 75-80.

Escobar, M., Scherer, J. N., Soares, C. M., Guimarães, L. S., Hagen, M. E., von Diemen, L., & Pechansky, F. (2018). Active Brazilian crack cocaine users: nutritional, anthropometric, and drug use profiles. Brazilian Journal of Psychiatry, 40, 354-360.

Forrester, J. E., Tucker, K. L., & Gorbach, S. L. (2004). Dietary intake and body mass index in HIV-positive and HIV-negative drug abusers of Hispanic ethnicity. Public health nutrition, 7(7), 863-870.

Forrester, J. E., Tucker, K. L., & Gorbach, S. L. (2005). The effect of drug abuse on body mass index in Hispanics with and without HIV infection. Public Health Nutrition, 8(1), 61-68.

French, E. D. (1997). Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neuroscience letters, 226(3), 159-162.

Friese, B., Slater, M. D., Annechino, R., & Battle, R. S. (2016). Teen use of marijuana edibles: A focus group study of an emerging issue. The Journal of Primary Prevention, 37(3), 303-309.

Galhardo, M. S. (2015). INTEGRATED ANALYSIS OF TRANSCRIPT-LEVEL REGULATION OF HUMAN ADIPOGENESIS AND CELL TYPE-SELECTIVE DISEASE ASSOCIATION OF HIGH REGULATORY LOAD GENES (Doctoral dissertation, University of Luxembourg, Luxembourg, Luxembourg).

Gallwitz, B. (2012). Anorexigenic effects of GLP-1 and its analogues. Appetite Control, 185-207.

Gaoni, Y., & Mechoulam, R. (1964). Isolation, structure, and partial synthesis of an active constituent of hashish. Journal of the American chemical society, 86(8), 1646-1647.

Gessa, G., Melis, M., Muntoni, A., & Diana, M. (1998). Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. European journal of pharmacology, 341(1), 39-44.

Gold, M. S., Frost-Pineda, K., & Jacobs, W. S. (2003). Overeating, binge eating, and eating disorders as addictions. Psychiatric Annals, 33(2), 117-122.

Golub, M. S. (2000). Cigarette smoking, substance abuse, nutritional status, and immune function. In Nutrition and Immunology (pp. 275-280). Humana Press, Totowa, NJ.

Greenwell, L., & Brecht, M. L. (2003). Self-reported health status among treated methamphetamine users. The American Journal of Drug and Alcohol Abuse, 29(1), 75-104.

Guilland, J. C., de Caryalho, M. C., Moreau, D., Boggio, V., Lhuissier, M., & Fuchs, F. (1994). Interrelationships of alcohol intake with blood vitamin status in nonalcoholic subjects. Nutrition research, 14(9), 1317-1330.

Haass-Koffler, C. L., Aoun, E. G., Swift, R. M., De La Monte, S. M., Kenna, G. A., & Leggio, L. (2015). Leptin levels are reduced by intravenous ghrelin administration and correlated with cue-induced alcohol craving. Translational psychiatry, 5(9), e646-e646.

Hatcher, A. S. (2004). Weight matters during recovery: unhealthy eating behaviors can impede client progress. Addiction Professional, 2(6), 23-4.

Hauser, M. B., & Iber, F. L. (1989). Nutritional advice and diet instruction in alcoholism treatment. Alcohol Health & Research World, 13(3), 261-267.

Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: implications for substance abuse prevention. Psychological bulletin, 112(1), 64.

Hillers, V. N., & Massey, L. K. (1985). Interrelationships of moderate and high alcohol consumption with diet and health status. The American journal of clinical nutrition, 41(2), 356-362.

Himmelgreen, D. A., Pérez‐Escamilla, R., Segura‐Millán, S., Romero‐Daza, N., Tanasescu, M., & Singer, M. (1998). A comparison of the nutritional status and food security of drug‐using and non‐drug‐using Hispanic women in Hartford, Connecticut. American Journal of Physical Anthropology: The Official Publication of the American Association of Physical Anthropologists, 107(3), 351-361.

Hofford, R. S., Russo, S. J., & Kiraly, D. D. (2019). Neuroimmune mechanisms of psychostimulant and opioid use disorders. European Journal of Neuroscience, 50(3), 2562-2573,

Hossain, K. J., Kamal, M. M., Ahsan, M., & Islam, S. K. (2007). Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle. Substance Abuse Treatment, Prevention, and Policy, 2(1), 1-7.

https://www.healthline.com/health/marijuana-abuse-and-addiction

Islam, S. N., Hossain, K. J., Ahmed, A., & Ahsan, M. (2002). Nutritional status of drug addicts undergoing detoxification: prevalence of malnutrition and influence of illicit drugs and lifestyle. British Journal of Nutrition, 88(5), 507-513.

Jerlhag, E., Egecioglu, E., Dickson, S. L., Douhan, A., Svensson, L., & Engel, J. A. (2007). Preclinical study: ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addiction biology, 12(1), 6-16.

Jerlhag, E., Egecioglu, E., Landgren, S., Salomé, N., Heilig, M., Moechars, D., & Engel, J. A. (2009). Requirement of central ghrelin signaling for alcohol reward. Proceedings of the National Academy of Sciences, 106(27), 11318-11323.

Jeynes, K. D., & Gibson, E. L. (2017). The importance of nutrition in aiding recovery from substance use disorders: A review. Drug and alcohol dependence, 179, 229-239.

Jias, L. M., & Ellison, G. (1990). Chronic nicotine induces a specific appetite for sucrose in rats. Pharmacology Biochemistry and Behavior, 35(2), 489-491.

Justinova, Z., Solinas, M., Tanda, G., Redhi, G. H., & Goldberg, S. R. (2005). The endogenous cannabinoid anandamide and its synthetic analog R (+)-methanandamide are intravenously self-administered by squirrel monkeys. Journal of Neuroscience, 25(23), 5645-5650.

Keshavarzian, A., Farhadi, A., Forsyth, C. B., Rangan, J., Jakate, S., Shaikh, M., ... & Fields, J. Z. (2009). Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. Journal of hepatology, 50(3), 538-547.

Kiraly, D. D., Walker, D. M., Calipari, E. S., Labonte, B., Issler, O., Pena, C. J., & Nestler, E. J. (2016). Alterations of the host microbiome affect behavioral responses to cocaine. Scientific reports, 6(1), 1-12.

Klausen, M. K., Thomsen, M., Wortwein, G., & Fink‐Jensen, A. (2022). The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders. British Journal of Pharmacology, 179(4), 625-641.

Knochel, J. P. (1988). Derangements of univalent and divalent ions in chronic alcoholism. The kidney in liver disease. 3rd ed. Baltimore: Williams & Wilkins, 132-53.

Koob, G. F. (2000). Neurobiology of addiction: toward the development of new therapies. Annals of the New York Academy of Sciences, 909(1), 170-185.

Koob, G. F., & Le Moal, M. D. (2001). desregulación de la recompensa y alostasis. Neuropsicofarmacología, 24, 97-129.

Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35(1), 217-238.

Krahn, D. D. (1991). The relationship of eating disorders and substance abuse. Journal of Substance Abuse, 3(2), 239-253.

Kuhar, M. J. (2016). CART peptides and drugs of abuse: a review of recent progress. Journal of drug and alcohol research, 5.

Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., ... & de Timary, P. (2012). Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain, behavior, and immunity, 26(6), 911-918.

Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Stärkel, P. (2014). Role of inflammatory pathways, blood mononuclear cells, and gut-derived bacterial products in alcohol dependence. Biological psychiatry, 76(9), 725-733.

Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., ... & Delzenne, N. M. (2014). Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proceedings of the National Academy of Sciences, 111(42), E4485-E4493.

Leggio, L. (2010). Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases. Drug news & perspectives, 23(3), 157-166.

Leggio, L., Ferrulli, A., Cardone, S., Nesci, A., Miceli, A., Malandrino, N., ... & Addolorato, G. (2012). Ghrelin system in alcohol‐dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving. Addiction biology, 17(2), 452-464.

Li, J., Li, Y., Gong, Z., Zhang, J., Zhou, Z., Tan, X., & Li, L. (2021). Major and trace elements changes of female methamphetamine addicts during six months’ compulsory treatment: Biomarkers discovery. Forensic Science International, 325, 110892.

Lieber, C. S. (2003). Relationships between nutrition, alcohol use, and liver disease. Alcohol Research & Health, 27(3), 220.

Lin, S. H., Yang, Y. K., Lee, S. Y., Hsieh, P. C., Chen, P. S., Lu, R. B., & Chen, K. C. (2012). Association between cholesterol plasma levels and craving among heroin users. Journal of addiction medicine, 6(4), 287-291.

Lv, D., Zhang, M., Jin, X., Zhao, J., Han, B., Su, H.,& He, J. (2016). The body mass index, blood pressure, and fasting blood glucose in patients with methamphetamine dependence. Medicine, 95(12).

Lyle, M. H. (2006). The reclassification of sugar as a drug.

Maccari, S., Bassi, C., Zanoni, P., & Plancher, A. C. (1991). Plasma cholesterol and triglycerides in heroin addicts. Drug and alcohol dependence, 29(2), 183-187.

Mahani, S. E., Motamedi, F., & Ahmadiani, A. (2006). Involvement of hypothalamic pituitary adrenal axis on the nifedipine-induced antinociception and tolerance in rats. Pharmacology Biochemistry and Behavior, 85(2), 422-427.

Mahboub, N., Rizk, R., Karavetian, M., & de Vries, N. (2021). Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review. Nutrition reviews, 79(6), 627-635.

Marijuana Abuse and Addiction.

Marr, L. CRx MAGAZINE.

Masoomi, M., Azdaki, N., & Shahouzehi, B. (2015). Elevated plasma homocysteine concentration in opium-addicted individuals. Addiction & health, 7(3-4), 149.

Masoomi, M., Ramezani, M. A., & Karimzadeh, H. (2010). The relationship of opium addiction with coronary artery disease. International journal of preventive medicine, 1(3).

Meckel, K. R., & Kiraly, D. D. (2019). A potential role for the gut microbiome in substance use disorders. Psychopharmacology, 236(5), 1513-1530.

Miller, R. P. (2010). Nutrition in addiction recovery. Many Hands Sustainability Center.

Montazerifar, F., Karajibani, M., & Lashkaripour, K. (2012). Effect of methadone maintenance therapy on anthropometric indices in opioid dependent patients. International journal of high risk behaviors & addiction, 1(3), 100.

Moussawi, K., Pacchioni, A., Moran, M., Olive, M. F., Gass, J. T., & Lavin, A. (2009). N-acetylcystein omvandlar kokaininducerad metaplasticitet. Nat Neurosci, 12(2), 182-189.

Myhre, J. B., Løken, E. B., Wandel, M., & Andersen, L. F. (2015). The contribution of snacks to dietary intake and their association with eating location among Norwegian adults–results from a cross-sectional dietary survey. BMC Public Health, 15(1), 1-9.

Nabipour, S., Mas, A. Y. U., & Habil, M. H. (2014). Burden and nutritional deficiencies in opiate addiction-systematic review article. Iranian journal of public health, 43(8), 1022.

Neale, J., Nettleton, S., Pickering, L., & Fischer, J. (2012). Eating patterns among heroin users: a qualitative study with implications for nutritional interventions. Addiction, 107(3), 635-641.

NIH Guide Alcohol, Hormones and Medical complications. 1997; 26(18): 97-062.P.T.34.

Noble, C., & McCombie, L. (1997). Nutritional considerations in intravenous drug misusers: a review of the literature and current issues for dietitians. Journal of Human nutrition and Dietetics, 10(3), 181-191.

Nolan, L. J., & Scagnelli, L. M. (2007). Preference for sweet foods and higher body mass index in patients being treated in long-term methadone maintenance. Substance use & misuse, 42(10), 1555-1566.

Nowack, K. M., & Pentkowski, A. M. (1994). Lifestyle habits, substance use and predictors of job burnout in professional working women. Work & Stress, 8(1), 19-35.

Odeleye, O. E., & Watson, R. R. (1992). Role of nutrition in alcoholism. Journal of Applied Nutrition, 44(1), 50-62.

Panagopoulos, V. N., & Ralevski, E. (2014). The role of ghrelin in addiction: a review. Psychopharmacology, 231(14), 2725-2740.

Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000). Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. Journal of hepatology, 32(5), 742-747.

Payne, J. L., Boyer, A. G., Brown, J. H., Finnegan, S., Kowalewski, M., Krause Jr, R. A., & Wang, S. C. (2009). Two-phase increase in the maximum size of life over 3.5 billion years reflects biological innovation and environmental opportunity. Proceedings of the National Academy of Sciences, 106(1), 24-27.

Peleg-Raibstein, D., Sarker, G., Litwan, K., Krämer, S. D., Ametamey, S. M., Schibli, R., & Wolfrum, C. (2016). Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. Translational psychiatry, 6(10), e911-e911.

Phillips, A. G., & LePiane, F. G. (1980). Reinforcing effects of morphine microinjection into the ventral tegmental area. Pharmacology Biochemistry and Behavior, 12(6), 965-968.

Puhl, M. D., Cason, A. M., Wojnicki, F. H., Corwin, R. L., & Grigson, P. S. (2011). A history of bingeing on fat enhances cocaine seeking and taking. Behavioral neuroscience, 125(6), 930.

Quach, L. A., Wanke, C. A., Schmid, C. H., Gorbach, S. L., Mwamburi, D. M., Mayer, K. H., ... & Tang, A. M. (2008). Drug use and other risk factors related to lower body mass index among HIV-infected individuals. Drug and alcohol dependence, 95(1-2), 30-36.

Ródenas-González, F., BLANCO-GANDÍA, C. A. R. M. E. N., Minarro Lopez, J., & Rodríguez-Arias, M. (2021). Behavioral and neuroimmune characterization of resilience to social stress: Rewarding effects of cocaine. Adicciones, 33(4).

Ross, L. J., Wilson, M., Banks, M., Rezannah, F., & Daglish, M. (2012). Prevalence of malnutrition and nutritional risk factors in patients undergoing alcohol and drug treatment. Nutrition, 28(7-8), 738-743.

Saeland, M., Haugen, M., Eriksen, F. L., Smehaugen, A., Wandel, M., Böhmer, T., & Oshaug, A. (2009). Living as a drug addict in Oslo, Norway–a study focusing on nutrition and health. Public health nutrition, 12(5), 630-636.

Saeland, M., Haugen, M., Eriksen, F. L., Wandel, M., Smehaugen, A., Böhmer, T., & Oshaug, A. (2011). High sugar consumption and poor nutrient intake among drug addicts in Oslo, Norway. British journal of nutrition, 105(4), 618-624.

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017). Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry. Translational Research, 179, 223-244.

Santolaria-Fernández, F. J., Gómez-Sirvent, J. L., González-Reimers, C. E., Batista-López, J., Jorge-Hernández, J., Rodríguez-Moreno, F., ... & Hernández-Garcia, M. T. (1995). Nutritional assessment of drug addicts. Drug and Alcohol Dependence, 38(1), 11-18.

Savage, D. C. (1977). Microbial ecology of the gastrointestinal tract. Annual review of microbiology, 31(1), 107-133.

Schroeder, R. D., & Higgins, G. E. (2017). You are what you eat: the impact of nutrition on alcohol and drug use. Substance Use & Misuse, 52(1), 10-24.

Scofield, M. D., & Kalivas, P. W. (2014). Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. The Neuroscientist, 20(6), 610-622.

Semba, R. D., Shah, N., Strathdee, S. A., & Vlahov, D. (2002). High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection. Journal of acquired immune deficiency syndromes (1999), 29(2), 142-144.

Silvestro, S., & Ellyn Vohnoutka, B. S. N. Alcoholism: signs, causes, and treatments.

Sirohi, S., Van Cleef, A., & Davis, J. F. (2017). Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats. Pharmacology Biochemistry and Behavior, 153, 105-115.

Smit, E., & Crespo, C. J. (2001). Dietary intake and nutritional status of US adult marijuana users: results from the Third National Health and Nutrition Examination Survey. Public health nutrition, 4(3), 781-786.

Solinas, M., Yasar, S., & Goldberg, S. R. (2007). Endocannabinoid system involvement in brain reward processes related to drug abuse. Pharmacological research, 56(5), 393-405.

Spronk, D. B., van Wel, J. H., Ramaekers, J. G., & Verkes, R. J. (2013). Characterizing the cognitive effects of cocaine: a comprehensive review. Neuroscience & Biobehavioral Reviews, 37(8), 1838-1859.

Stickel, A., Rohdemann, M., Landes, T., Engel, K., Banas, R., Heinz, A., & Müller, C. A. (2016). Changes in nutrition-related behaviors in alcohol-dependent patients after outpatient detoxification: the role of chocolate. Substance use & misuse, 51(5), 545-552.

Stockton Jr, S. D., & Devi, L. A. (2012). Functional relevance of μ–δ opioid receptor heteromerization: A Role in novel signaling and implications for the treatment of addiction disorders: From a symposium on new concepts in mu-opioid pharmacology. Drug and alcohol dependence, 121(3), 167-172.

Suwanwela, C., & Poshyachinda, V. (1986). Drug abuse in Asia. Bulletin on Narcotics, 38(1-2), 41-53.

Tang, A. M., Bhatnagar, T., Ramachandran, R., Dong, K., Skinner, S., Kumar, M. S., & Wanke, C. A. (2011). Malnutrition in a population of HIV-positive and HIV-negative drug users living in Chennai, South India. Drug and alcohol dependence, 118(1), 73-77.

Taylor, A. H., & Ussher, M. H. (2005). Effects of exercise on smoking cessation and coping with withdrawal symptoms and nicotine cravings. In Exercise, health and mental health (pp. 135-158). Routledge.

Teixeira, J., Mota, T., & Fernandes, J. C. (2011). Nutritional evaluation of alcoholic inpatients admitted for alcohol detoxification. Alcohol and alcoholism, 46(5), 558-560.

Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017). The microbiota, the gut and the brain in eating and alcohol use disorders: a ‘Ménage à Trois’?. Alcohol and alcoholism, 52(4), 403-413.

Thorsell, A., & Mathé, A. A. (2017). Neuropeptide Y in alcohol addiction and affective disorders. Frontiers in Endocrinology, 8, 178. Today's Dietitian. 2014. Vol. 16 No. 12 P. 44

Torrens, M., Domingo-Salvany, A., Alonso, J., Castillo, C., & San, L. (1999). Methadone and quality of life. The Lancet, 353(9158), 1101.

Trinko, R., Sears, R. M., Guarnieri, D. J., & DiLeone, R. J. (2007). Neural mechanisms underlying obesity and drug addiction. Physiology & behavior, 91(5), 499-505.

Uong, S., Tomedi, L. E., Gloppen, K. M., Stahre, M., Hindman, P., Goodson, V. N.,& Brewer, R. D. (2022). Screening for excessive alcohol consumption in emergency departments: a nationwide assessment of emergency department physicians. Journal of public health management and practice, 28(1), E162-E169.

Usha, R., Sailesh, K. S., Divya, D., VK, M. J., Angel, J., & Mukkadan, J. K. (2013). A study on comparison of random blood glucose levels in alcoholic and non-alcoholic males of Ernakulam district, Kerala. Asian Journal of Health Sciences, 1(1).

Vainio, A., Rosenberg, P., Kalso, E., Ollila, J., & Matikainen, E. (1995). Driving ability in cancer patients receiving long-term morphine analgesia. The Lancet, 346(8976), 667-670.

Varela, P., Marcos, A., Ripoll, S., Santacruz, I., & Requejo, A. M. (1997). Effects of human immunodeficiency virus infection and detoxification time on anthropometric measurements and dietary intake of male drug addicts. The American journal of clinical nutrition, 66(2), 509S-514S.

Vickers, N. J. (2017). Animal communication: when i’m calling you, will you answer too?. Current biology, 27(14), R713-R715.

Villavasso, S., Shaw, C., Skripnikova, E., Shah, K., Davis, J. F., & Sirohi, S. (2019). Nutritional contingency reduces alcohol drinking by altering central neurotransmitter receptor gene expression in rats. Nutrients, 11(11), 2731.

Virk, S., Schwartz, T. L., Jindal, S., Nihalani, N., & Jones, N. (2004). Psychiatric medication induced obesity: an aetiologic review. Obesity reviews, 5(3), 167-170.

Volkow, N. D. (2006). Stimulant medications: how to minimize their reinforcing effects?. American Journal of Psychiatry, 163(3), 359-361.

Volkow, N. D. (2010). Drugs, brains, and behavior: The science of addiction. Retrieved on March, 23(2011), 255-169.

Volkow, N. D., Fowler, J. S., Wang, G. J., Swanson, J. M., & Telang, F. (2007). Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Archives of neurology, 64(11), 1575-1579.

Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

Walker LC, Lawrence AJ. The role of orexins/hypocretins in alcohol use and abuse. Behavioral Neuroscience of Orexin/Hypocretin. 2016:221-46.

Wang, S. C., Chen, Y. C., Chen, S. J., Lee, C. H., & Cheng, C. M. (2020). Alcohol addiction, gut microbiota, and alcoholism treatment: A review. International journal of molecular sciences, 21(17), 6413.

Westerink, B. H., & Korf, J. (1976). Regional rat brain levels of 3, 4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorometric measurement and influence of drugs. European Journal of Pharmacology, 38(2), 281-291.

White, R. (2010). Drugs and nutrition: how side effects can influence nutritional intake. Proceedings of the Nutrition Society, 69(4), 558-564.

Xu, Y., Xie, Z., Wang, H., Shen, Z., Guo, Y., Gao, Y., ... & Wang, K. (2017). Bacterial diversity of intestinal microbiota in patients with substance use disorders revealed by 16S rRNA gene deep sequencing. Scientific reports, 7(1), 1-9.

Zacny, J. P., & Gutierrez, S. (2003). Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology, 170(3), 242-254.

Zacny, J. P., & Lichtor, S. A. (2008). Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine in non-drug-abusing volunteers. Psychopharmacology, 196(1), 105-116.

Zacny, J. P., Gutierrez, S., & Bolbolan, S. A. (2005). Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. Drug and alcohol dependence, 78(3), 243-252.

Zangen, A., Solinas, M., Ikemoto, S., Goldberg, S. R., & Wise, R. A. (2006). Two brain sites for cannabinoid reward. Journal of Neuroscience, 26(18), 4901-4907.

Zhang, M., Lv, D., Zhou, W., Ji, L., Zhou, B., Chen, H., & He, J. (2017). The levels of triglyceride and total cholesterol in methamphetamine dependence. Medicine, 96(16).