Correlation between FEV1/FVC ratio with Body Mass Index (BMI) and absolute eosinophils in patients with acute exacerbation of asthma at Mataram City Hospital, West Nusa Tenggara in 2019–2020
Keywords:
BMI, absolute eosinophils, asthma, FEV1/FVCAbstract
This study aimed to analyze Correlation between FEV1/FVC ratio with body mass index (BMI) and absolute eosinophils in patients with acute exacerbation of asthma. A cross sectional study based on the medical records of asthma patients from June 2019 to June 2020, with a total population of 180 cases conducted at Mataram City Regional General Hospital, West Nusa Tenggara. The data were analyzed using multiple linier regression using SPSS. The data collected showed that getting older reduces the value of FEV1/FVC, but it is not statistically significant (b= -0.03; 95% CI= -0.18 to 0.13; p= 0.746). Male gender has a lower probability of having a FEV1/FVC value than female sex, but it is not statistically significant (b= -2.78; 95% CI= -6.38 to 0.83; p= 0.130). An increase in the eosinophil score reduced the FEV1/FVC value by 6.03 units and was statistically significant (b= -6.03; 95% CI= -7.80 to -4.26; p< 0.001). An increase in body mass index decreased the FEV1/FVC value by 1.22 units and was statistically significant (b= -1.22; 95% CI= -1.71 to -0.75; p< 0.001).
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References
Amanda, G. (2015). Obesitas dan Asma (Obesity and Asthma). RS PMC Pekanbaru, Riau, Indonesia.
Andayani, N. (2017). Hubungan Obesitas Terhadap Asma (The Correlation between Obesity and Asthma). Jurnal Kedokteran Syiah Kuala, 17(1), 54-59.
Data Rekam Medik RSUD Kota Mataram. (2021). RSUD Kota Mataram. Accessed at June, 2019.
Fasitasari, M. (2013). Terapi Gizi pada Lanjut Usia dengan Penyakit Paru Obstruktif Kronik (PPOK) (Nutrition therapy in Elderly with Chronic Obstructive Pulmonary Disease (COPD) Januari - Juni 2013. Sains Medika. 5(1), 50-61.
Fujianti, P., Hasyim, H., & Sunarsih, E. (2015). Faktor-Faktor yang Mempengaruhi Timbulnya Keluhan Gangguan Pernapasan pada Pekerja Mebel Jati Berkah Kota Jambi (Factors Associated with the Occurrence of Complaints of Respiratory Disorders in Teak Furniture Workers in the City of Jambi). Jurnal Ilmu Kesehatan Masyarakat, 6(3).
Global Initiative for Asthma (GINA). (2019). Pocket Guide for Asthma Management and Prevention. Cape Town: Global Initiative for Asthma
Haitamy, N., & Kadarullah, O. (2017). Pengaruh Obesitas Terhadap Terjadinya Penyakit Asma Di RS Islam Fatimah Cilacap. Sainteks, 12(2).
Hall, J. E. (2016). Guyton and Hall Textbook of Medical Physiology (13th ed.). Elsevier, Inc.
Hancox, R. J., Pavord, I. D., & Sears, M. R. (2018). Associations Between Blood Eosinophils and Decline in Lung Function Among Adults With and Without Asthma. European Respiratory Journal, 51(4). Doi: 10.1183/13993003.02536-2017
James H Hull. (2020). Lung Function Testing in the COVID-19 Endemic. Lung Function Department, Royal Brompton Hospital, London SW3 6HP, UK (JHH); and Lung Function & Sleep, University Hospitals Birmingham NHSF Trust, Birmingham.
Kemenkes RI. (2019). Laporan Nasional RISKESDAS 2018. Kemenkes RI. http://labdata.¬lit¬bang.¬kemkes.go.id/. Accessed at October 2020.
Kerkhof, M., Tran, T. N., van den Berge, M., Brusselle, G. G., Gopalan, G., Jones, R. C. M., Kocks., et al. (2018). Association between blood eosinophil count and risk of readmission for patients with asthma: Historical cohort study. PloS one, 13(7), e0201143. Doi: 10.1371/journal.pone.0201143
Liu, Y., Pleasants, R. A., Croft, J. B., Lugogo, N., Ohar, J., Heidari, K., Strange, C., et al. (2015). Body mass index, respiratory conditions, asthma, and chronic obstructive pulmonary disease. Respiratory medicine, 109(7), 851–859. Doi: 10.1016/j.rmed.¬2015.05.006
Nair, P., Pizzichini, M. M., Kjarsgaard, M., Inman, M. D., Efthimiadis, A., Pizzichini, E., Hargreave, F. E., & O'Byrne, P. M. (2009). Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. The New England journal of medicine, 360(10), 985–993. Doi: 10.1056/NEJMoa0805435
Nasiri, K, R., Hamedi, R., Nasirian, R., Farsani, M., Kashefi, H., Khalafi, B., & Kooti, W. (2016). Association of body mass index with asthma severity and pulmonary function among asthmatic children. International Journal of Pediatrics, 4(9), 3551-3559. Doi: 10.¬22038/ijp.2016.7316
Nisa, A., Afghani, A., Dharmmika, S., & Muhammad. (2019). Hubungan Kejadian Asma Bron¬kial dengan Jumlah Eosinofil Total Darah Tepi. Prosiding Pendidikan Dokter, 045(22), 318–325. Doi: 10.29313/kedokteran.v0i0.14915.
Ortega, H., Yancey, S. W., Keene, O. N., & Gunsoy, N. B. (2018). Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma Study Population. The Journal of Allergy and Clinical Immunology in Practice, 6(3), 980-986.e1. Doi: 10.1016/j.jaip.2017.12.019
Ostrowski, S., & Barud, W. (2006). Factors influencing lung function: are the predicted values for spirometry reliable enough?. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 57 Suppl 4, 263–271.
PDPI. (2020). SPO Spirometri pada Masa Pandemi COVID-19. www.klikpdpi.com
Rahmawati, Galih Lidya, and Muhammad Fachri. (2014). Comparison of Various Degree of Stable Asthmatic Patients With Obesity and Normoweight at Jakarta Islamic Hospital Sukapura. Journal Of The Indonesian Medical Association Majalah Kedokteran Indo¬nesia 64(2).
Sabirina. N. A. (2011). Perbedaan Fungsi Paru antara Penderita Asma Obesitas dan Normoweight rentan Usia 30-40 tahun di Poli Asma RSUP Persahabatan periode Agustus 2008-Agustus 2010. Skripsi Fakultas Kedokteran UPN Veteran Jakarta, 1-47.
Shore S. A. (2008). Obesity and asthma: possible mechanisms. The Journal of allergy and clinical immunology, 121(5), 1087–1095. Doi: 10.1016/j.jaci.2008.03.004
Sutherland, T. J., Cowan, J. O., Young, S., Goulding, A., Grant, A. M., Williamson, A., Brassett, K., et al. (2008). The association between obesity and asthma: interactions between systemic and airway inflammation. American journal of respiratory and critical care medicine, 178(5), 469–475. Doi: 10.1164/rccm.200802-301OC
Vedel-Krogh, S., Nielsen, S. F., Lange, P., Vestbo, J., & Nordestgaard, B. G. (2017). Association of Blood Eosinophil and Blood Neutrophil Counts with Asthma Exacerbations in the Copenhagen General Population Study. Clinical Chemistry, 63(4), 823–832. Doi: 10.1373/clinchem.2016.267450
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