Synthesis, characterization and biological activity of new complexes from Manniche base ligands derived from amoxicillin
Keywords:
Mannich base, complexes, organic ligands, amoxicillin, Staphylococcus AurousAbstract
The importance of Manniche bases increased in pharmaceutical research, especially those prepared from pharmaceutical compounds. The study aims for an alternative design of a Manniche base of amoxicillin from sodium saccharin and benzaldehyde and ensures their consistency with some salts of transition elements Co (II), Ni (II), Cu (II), and Mn(II). They determined the expected stereo isometries of the resulting complexes Where the prepared complexes took the form of octahedral by diagnosing them by appropriate spectral and physical methods, infrared spectra (FT-IR), nuclear magnetic resonance spectroscopy (1H-NMR), accurate analysis of elements (C.H.N.S), Molar conductivity and measurement of melting points. The biological efficacy of all prepared compounds was studied, and two types of bacteria (Staphylococcus Aurous) and (Escherichia coli) were selected. Inhibition of bacteria at concentration (10-3) were studied.
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References
Ahmed .A. Samir .M. El Rayes. ACS Omega , 6, 8,( 2021)5244–5254
Ali, Rana A., and Suad M. Al-Araji. Baghdad Science Journal 9.1 (2012): 168-177.
Andraos,John.thealgebraof organic synthesis.green metrics, design strategy,route selection andoptimization, C.R.C. press 2016
Ayneni,A.O,Watkine,G.M.Bulletin oftheChemical Socity of Ethiopia,33(2)2019, 341-348
Deepak M. Nagrik and Umesh S. Shelke2020 J. Phys.: Conf. Ser. 1644 012018
Diaz-Oviedo.C,&Quevedo,R. Journal of Molecular Struture, , 127283 (2020) 1202
Fu.Yun, Yang.Y, Zhou,S, Y.Yanbin, International Journal of Oncology, 45 (2014) 2092-2100
Guo,H.EuopeanJournal ofmedicinal chemistry,164.(2019)678-688
H. Leqin,Q. Shenjun, C.Tao, S.Yuzhuang and Z.Jiquan, Int. Jour. Mol. Sci.,15, (2014). 8656-8666
Kalaivanan,C.Sankaranesh,M. Journal ofMolecularLiquids,320(2020)114423
M.Travnicek and M Potacek.Molecules.2(1999)238-244
Mohamed M. Ibrahim A.C.S. Omega 2021, 6, 8, 5244–5254
Rapacz,A.Rybka, S.Obniska,J Euopean Journal ofPharmcology869(2020) 172890.
S. M. Jo seph, Ph. D. Thesis, Stockholm University, (2005).
Seivearaj, S. David, R. Krishnaveni, and Dhanapal Tamilvendan. Material Today: Proceedings 33(2020): 4271-4279.
Shareef,T,H,M,A&Padusha,M,S,A.Int.J.Pharm.Sci6,(2014)466-472
Shehab, Omer H., and Ayaa S. Amer. activity. Journal of university of Anbar for Pure science 8.2(2014).
Sivakami.M.,Natarajan.B..M.,ChemicalScienceTransactions,3(3).(2014)1110-1114
Subramaniapillai, Selva Ganesan .''Mannich reaction :A versatile and convenient approach to bioactive skeletons.'' Journal of Chemical Sciences 125.3 (2013):467-482.
Tamer,A.A&Qassir,A,J.IraqiJouranalofpharmaceticalSciences,28(1)2019,124-130.
William J. Burke J. Org. Chem. 1964, 29, 2, 407–410
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