Synthesis, characterization and biological activity of new complexes from Manniche base ligands derived from amoxicillin
Keywords:
Mannich base, complexes, organic ligands, amoxicillin, Staphylococcus AurousAbstract
The importance of Manniche bases increased in pharmaceutical research, especially those prepared from pharmaceutical compounds. The study aims for an alternative design of a Manniche base of amoxicillin from sodium saccharin and benzaldehyde and ensures their consistency with some salts of transition elements Co (II), Ni (II), Cu (II), and Mn(II). They determined the expected stereo isometries of the resulting complexes Where the prepared complexes took the form of octahedral by diagnosing them by appropriate spectral and physical methods, infrared spectra (FT-IR), nuclear magnetic resonance spectroscopy (1H-NMR), accurate analysis of elements (C.H.N.S), Molar conductivity and measurement of melting points. The biological efficacy of all prepared compounds was studied, and two types of bacteria (Staphylococcus Aurous) and (Escherichia coli) were selected. Inhibition of bacteria at concentration (10-3) were studied.
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