Comparison of the effect of acetaminophen and licorice-based traditional medicine on reducing pain of patients undergoing adenotonsillectomy, a pilot randomized clinical trial study

Mehdi Nikkhah; Seyde-Sedighe Yousefi; Rostam Pourmousa; Ali Fahimi; Fatemeh Seyfi; Omid Sadeghpour

doi:10.53730/ijhs.v5nS2.13890

Authors

Mehdi Nikkhah Assistant professor, Department of Otorhinolaryngology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Seyde-Sedighe Yousefi Assistant professor of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran | Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
Rostam Pourmousa Assistant professor, Department of Otorhinolaryngology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Ali Fahimi Assistant professor, Department of Otorhinolaryngology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Fatemeh Seyfi
Seyfi.fatemeh2022@gmail.com
Medical student, Student research committee, Mazandaran University of Medical Sciences, Sari, Iran
Omid Sadeghpour Assistant Professor of Pharmacognosy, School of Persian Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran

Keywords:

adenotonsillectomy, licorice, acetaminophen, pain

Abstract

Introduction: Adenotonsillectomy is one of the common surgeries specifically performed in children. The major complication of this surgery is post-surgery pains. The present study compared the effect of acetaminophen and licorice-based traditional medicine for the alleviation pain in patients with adenotonsillectomy. Materials and Method: This single-blinded pilot clinical trial study was carried on 3–15-year-old patients who had undergone tonsillectomy. After the surgery patients of both groups received 10 mg/kg syrup of acetaminophen every six hours for 24 hours. In addition, in the patients of the experimental group, licorice lozenges (with doses of 1000 mg) were administered. Wong-Baker’s Faces Pain Scale was used to measure the level of pains. Results: A total of 40 patients were assessed. Friedman test demonstrated that the mean pain of the two groups showed significant reduction (p=0.001). Also, the Mann-Whitney-U test revealed that the mean pain severity in the licorice-receiving group in 6 (p=0.056), 12 (p=0.02) and 18 (p=0.006) hours after the surgery significantly decreased compared to that of the control group. Conclusion: The level of pain reduction after adenotonsillectomy in the licorice group was significantly higher than that in the control group.

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