Comparison of diagnostic accuracy of magnetic resonance spectroscopy with conventional magnetic resonance imaging for brain tumors and correlation with histopathology as gold standard

Mahwish Farzana; Madiha Naseer; Alia Ahmad; Maham Javaid; Aysha Akram; Zainab Jamil Khan; Shafiq Ahmad

doi:10.53730/ijhs.v6nS8.13947

Authors

Mahwish Farzana
mahwishfarzana70@gmail.com
MBBS, MD Radiology, AP Radiology Department, Farooq hospital, DHA branch, Lahore
Madiha Naseer BSc, MBBS, MD, SR Radiology Department, Shaikh Zayed PGMI, Lahore
Alia Ahmad Associate professor, Department of Hematology/Oncology, University of Child Health Sciences and children's Hospital, Lahore
Maham Javaid Anesthesia consultant, THQ Hospital safdarabad, sheikhupura
Aysha Akram Associate professor, Pediatric Radiology, University of Child Health Sciences and children's Hospital, Lahore
Zainab Jamil Khan Senior demonstrator Histopathology department, Shalamar medical college, Lahore
Shafiq Ahmad MBBS DMRD, EX HOD Radiology Department, Shaikh Zayed PGMI, Lahore

Keywords:

diagnostic accuracy, magnetic resonance spectroscopy, conventional magnetic resonance imaging, brain tumors, histopathology

Abstract

Background; Despite a large number of revolutionized advancements in Imaging technology clinicians are unable to get hundred percent accurate results. Multiple limitations have been observed in Imaging modalities. Multiple published trials are available online on the evaluations of these imaging modalities individually and in combinations to find out the level of accuracy of these technologies. Objective; This study was design to compare the diagnostic accuracy of MR Spectroscopy with MRI which is a conventional diagnostic tool for brain tumor diagnosis while keeping the Histopathology evaluation as Gold Standard. Methodology; The patients who fulfilled the inclusion criteria were included in study. All scans were carried out on GE 1.5 Tesla MR Scanner using head coil. Axial T1W, T2W, Fluid Attenuated Inversion Recovery (FLAIR), Sagittal T2W, Coronal Fluid Attenuation. Inversion Recovery (FLAIR) and T1W post- contrast Axial, Coronal and Sagittal images were acquired. MR spectroscopy was performed through single voxel technique. Final diagnosis was made on histopathology results. The reports of biopsy were co related with radiological diagnosis of MRI and MRS. Results; The study was conducted with 150 suspected cases. There were 85(56.7%) males and 65(43.3%) females. Histopathology 100(66.7%) cases were confirmed positive and 50(33.3%) negative.

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