Gynecological disorders as factors that could cause cervical neoplasia

https://doi.org/10.53730/ijhs.v6nS8.13976

Authors

  • Shahida Wazir Senior Registrar, Department of Gynecology and Obstetrics, Northwest School of Medicine, Peshawar, Pakistan
  • Afshan Inayat Senior Registrar, Department of Gynecology and Obstetrics, Northwest School of Medicine, Peshawar, Pakistan
  • Sanodia Afridi Assistant Professor, Department of Gynecology and Obstetrics, Northwest School of Medicine, Peshawar, Pakistan
  • Nayab Faridoon Senior Registrar, Department of Gynecology and Obstetrics, Muhammad teaching hospital, Peshawar, Pakistan
  • Ayesha Qadir Department of Histopathology, Khyber Medical University, Peshawar, Pakistan

Keywords:

gynecological disorders, human papillomavirus, cervical neoplasia, trichomonas vaginalis, preinvasive lesions, cancer, herpes simplex virus

Abstract

A longitudinal cohort research was conducted to see if gynaecological disorders besides the human papillomavirus (HPV) remain associated to the elevated threat to cervical neoplasia. The research included many women who participated in the planned mass screening. Trichomonas vaginalis and HPV, respectively, remained linked through a significant comparative probability of preinvasive lesions, cervical cancer and invasive cancer merged, and preinvasive lesions and invasive cancer combined. Despite its rarity in detection, the greatest and theoretically highly meaningful information system provides for Herpes simplex virus (HSV) was discovered. It was not demonstrated that actinomyces or yeast significantly increased the cervical cancer risk. The other illnesses' confounding effects were unable to explain any of these findings. This led us to propose that the herpes simplex virus and Trichomonas vaginalis are further cervical neoplasia predictors.

Downloads

Download data is not yet available.

References

Bjørge, T., Hjellvik, V., Bjørge, L., dos‐Santos‐Silva, I., Furu, K., Kvåle, R., & Engeland, A. (2023). Incidence and prevalence of drugs used for chronic diseases in survivors of adult‐onset gynaecological cancer‐a nationwide cohort study. BJOG: An International Journal of Obstetrics & Gynaecology.

Chan, C. K., Aimagambetova, G., Ukybassova, T., Kongrtay, K., & Azizan, A. (2019). Human papillomavirus infection and cervical cancer: epidemiology, screening, and vaccination—review of current perspectives. Journal of oncology, 2019.

Dattner, A. M. (2022). Herbal and Integrative Medicine-Associated Improvement of Viral-Induced Cervical and Vaginal Disorders: Case Report. Integrative Medicine Reports, 1(1), 235-239.

Gholizadeh, O., Yekanipour, Z., Kivi, S., Farahbod, F., Aqayinejad, M., Tasoujizade, Y., ... & Poortahmasebi, V. (2023). Review of the evidence of the effects of human papillomavirus infection and Gardnerella vaginalis, and their co-infection on infertility. Microbial Pathogenesis, 105980.

Gurumurthy, R. K., Koster, S., Kumar, N., Meyer, T. F., & Chumduri, C. (2022). Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection. Nature Protocols, 17(7), 1658-1690.

Horsboel, T. A., Kjaer, S. K., Johansen, C., Suppli, N. P., Ammitzbøll, G., Frøding, L. P., ... & Dalton, S. O. (2019). Increased risk for depression persists for years among women treated for gynecological cancers-a register-based cohort study with up to 19 years of follow-up. Gynecologic Oncology, 153(3), 625-632.

Kudela, E., Holubekova, V., Kolkova, Z., Kasubova, I., Samec, M., Mazurakova, A., & Koklesova, L. (2023). Vaginal Microbiome and Its Role in HPV Induced Cervical Carcinogenesis. In Microbiome in 3P Medicine Strategies: The First Exploitation Guide (pp. 43-86). Cham: Springer International Publishing.

Macios, A., Didkowska, J., Wojciechowska, U., Komerska, K., Glińska, P., Kamiński, M. F., & Nowakowski, A. (2021). Risk factors of cervical cancer after a negative cytological diagnosis in Polish cervical cancer screening programme. Cancer Medicine, 10(10), 3449-3460.

Mogavero, M. P., DelRosso, L. M., Fanfulla, F., Bruni, O., & Ferri, R. (2021). Sleep disorders and cancer: State of the art and future perspectives. Sleep Medicine Reviews, 56, 101409.

Mohamed, H. E. A. (2019). Evaluation of prognostic markers for oropharyngeal carcinoma using tissue microarray. Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis.

Plisko, O., Zodzika, J., Jermakova, I., Pcolkina, K., Prusakevica, A., Liepniece-Karele, I., ... & Rezeberga, D. (2021). Aerobic vaginitis—underestimated risk factor for cervical intraepithelial neoplasia. Diagnostics, 11(1), 97.

Tarapan, S., Matangkasombut, O., Trachootham, D., Sattabanasuk, V., Talungchit, S., Paemuang, W., ... & Lam‐ubol, A. (2019). Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients. Oral Diseases, 25(7), 1798-1808.

Vallianou, N., Kounatidis, D., Christodoulatos, G. S., Panagopoulos, F., Karampela, I., & Dalamaga, M. (2021). Mycobiome and cancer: what is the evidence?. Cancers, 13(13), 3149.

Wei, W., Xie, L. Z., Xia, Q., Fu, Y., Liu, F. Y., Ding, D. N., & Han, F. J. (2022). The role of vaginal microecology in the cervical cancer. Journal of Obstetrics and Gynaecology Research, 48(9), 2237-2254.

Wu, C. T., Chiu, L. T., & Raturi, V. P. (2023). Investigation of the Correlation Between Mental Disorder and Cervical Cancer in Taiwan: A Nationwide Population-Based Cohort Study. Indian Journal of Gynecologic Oncology, 21(1), 29.

Published

18-02-2023

How to Cite

Wazir, S., Inayat, A., Afridi, S., Faridoon, N., & Qadir, A. (2023). Gynecological disorders as factors that could cause cervical neoplasia. International Journal of Health Sciences, 6(S8), 6716–6721. https://doi.org/10.53730/ijhs.v6nS8.13976

Issue

Section

Peer Review Articles