The  effect of zinc supplementation in adolescent patients with acute diarrhoea

Muhammad Bilal Khattak; Muhammad Aqeel Khan; Arshia Munir

doi:10.53730/ijhs.v6nS8.13997

Authors

Muhammad Bilal Khattak Associate Professor, Department of Medicine (Medical B Unit), Hayatabad Medical Complex, Peshawar
Muhammad Aqeel Khan Professor, Department of Paediatrics (Children A Unit), Hayatabad Medical Complex, Peshawar
Arshia Munir
drarshia@yahoo.com
Assistant Professor, Khyber Teaching Hospital, Peshawar

Keywords:

acute diarrhoeal illness, zinc supplementation, efficacy

Abstract

Background: Despite the recommendation of zinc in the management of acute diarrhoeal illness, the effect has been seldomly reported in adolescent population. Objective: To evaluate the efficacy of zinc supplementation in acute diarrhoea in adolescent population. Study Design: Randomized Controlled Trial. Settings: Department of Medicine and Paediatrics, Hayatabad Medical Complex. Study duration: This study was conducted from 1^st February 2022 till 31^st October 2022. Materials and methods: Both male and female patients presenting with acute diarrhoeal illness were enrolled. Patients were equally divided through block randomization into two groups. Elemental zinc at 20mg BD was administered orally to the study group. Control group received mineral and vitamin supplementation except zinc. Efficacy was evaluated in terms of reduction in stool frequency and hospital stay. Results: Age of the patients ranged from 10 to 18 years. Mean age of the patients in study group was 14.83±3.730 years versus 13.90±3.806 years in control group. Mean stool frequency on presentation in study versus control group were 5.904±1.052 versus 6.089±1.472 respectively while on day it was 1.472±0.130 versus 2.937±640 respectively. Recovery was observed in 29 patients (93.5%) in study group as compared to 21 patients (67.7%) in control group.

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References

Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, et al. Efficacy of zinc-fortified oral rehydration solution in 6-to 35-month-old children with acute diarrhea. J Pediatr. 2002;141(5):677-82.

Boran P, Tokuc G, Vagas E, Oktem S, Gokduman MK. Impact of zinc supplementation in children with acute diarrhoea in Turkey. Arch Dis Child. 2006;91(4):296-9.

Dhingra U, Kisenge R, Sudfeld CR, Dhingra P, Somji S, Dutta A, et al. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. N Engl J Med. 2020;383(13):1231-41.

Hettiarachchi M, Liyanage C, Wickremasinghe R, Hilmers DC, Abrams SA. Prevalence and severity of micronutrient deficiency: a cross-sectional study among adolescents in Sri Lanka. Asia Pacific J Clin Nutr. 2006;15(1):56.

Hoque KM, Sarker R, Guggino SE, Tse CM. A new insight into pathophysiological mechanisms of zinc in diarrhea. Ann New York Acad Sci. 2009;1165:279-84.

Kawade R. Zinc status and its association with the health of adolescents: a review of studies in India. Glob Health Action. 2012;5:7353.

Laghari GS, Hussain Z, Shahzad H. Effect of Zinc Supplementation on the Frequency and Consistency of Stool in Children with Acute Diarrhea. Cureus. 2019;11(3):e4217.

Larson CP, Koehlmoos TP, Sack DA, Team SUoZfYCP. Scaling up zinc treatment of childhood diarrhoea in Bangladesh: theoretical and practical considerations guiding the SUZY Project. Health Policy Plan. 2012;27(2):102-14.

Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016;12(12):Cd005436.

Organization WH. Clinical management of acute diarrhoea: WHO. World Health Organization; 2004.

Patel A, Dibley MJ, Mamtani M, Badhoniya N, Kulkarni H. Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. BMC Med. 2009;7(1):22.

Rerksuppaphol L, Rerksuppaphol S. Efficacy of zinc supplementation in the management of acute diarrhoea: a randomised controlled trial. Paediatr Int Child Health. 2020;40(2):105-10.

Saeed A, Abd H, Sandstrom G. Microbial aetiology of acute diarrhoea in children under five years of age in Khartoum, Sudan. J Med Microbiol. 2015;64(Pt 4):432-7.

Saibaba A, Ram MM, Rao GR, Devi U, Syamala T. Nutritional status of adolescent girls of urban slums and the impact of IEC on their nutritional knowledge and practices. Indian J Commun Med. 2002;27(4):151.

Somji SS, Dhingra P, Dhingra U, Dutta A, Devi P, Kumar J, et al. Effect of dose reduction of supplemental zinc for childhood diarrhoea: study protocol for a double-masked, randomised controlled trial in India and Tanzania. BMJ Paediatr Open. 2019;3(1).

Stockman NK, Schenkel TC, Brown JN, Duncan AM. Comparison of energy and nutrient intakes among meals and snacks of adolescent males. Prevent Med. 2005;41(1):203-10.

Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics. 2002;109(5):898-903.

Trivedi SS, Chudasama RK, Patel N. Effect of Zinc Supplementation in Children with Acute Diarrhea: Randomized Double Blind Controlled Trial. Gastroenterol Res. 2009;2(3):168-74.

Walker CL, Black RE. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol. 2010;39 Suppl 1(Suppl 1):i63-9.