Role of clomiphene citrate in anovulation and hormonal imbalance of patients with polycystic ovarian syndrome

https://doi.org/10.53730/ijhs.v6nS9.14043

Authors

  • Tuba Tariq Assistant Professor Department of Radiology, Azra Naheed Medical College, Lahore
  • Muhammad Imran Professor, Department of Physiology, Continental Medical College, Lahore Pakistan
  • Fareeha Karamat Cheema Demonstrator Biochemistry, Gujranwala Medical College, Gujranwala Pakistan
  • Asma Ashraf Demonstrator Physiology, Continental Medical College, Lahore Pakistan
  • Sadia Haleema Associate Professor Biochemistry, Continental Medical College, Lahore Pakistan
  • Asma Arshad Assistant Professor Biochemistry, Continental Medical College, Lahore Pakistan

Keywords:

PCOS, Clomiphene citrate, anovulation

Abstract

This study was conducted to see the effects of Clomiphene Citrate on fertility hormones estrogen, progesterone, LH, FSH in patients with infertility associated with polycystic ovary syndrome. For this study fifty infertile patients with PCOS who were given treatment with clomiphene citrate (50–150mg/day for 5 days). For Ovarian response ovulation was monitored by transvaginal ultrasonography and serum levels of FSH, LH, progesterone, estrogen was also estimated by using ELISA methods.

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References

Ainavi, I. I., 2009. Pattern of Reproductive Hormones in Women with Infertility in Zaria, Nothern Nigeria (Doctoral disertation):1-70.

Bhagavath, B. and Carson, S. A., 2012. Ovulation induction in women with polycystic ovary syndrome: an update. American Journal of

Obstetrics & Gynecology, 206(3), 195-198

Y Maximov, P., M Lee, T. and Craig Jordan, V., 2013. The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice. Current clinical pharmacology, 8(2), 135-155.

Practice Committee of the American Society for Reproductive Medicine. 2006. Use of clomiphene citrate in women. Fertility and sterility, 86(5), S187-S191.

Huppert, L. C., 1982. Induction of ovulation with clomiphene citrate: 1.

Jacobson, A., Marshall, J. R., Ross, G. T. and Cargille, C. M., 1968. Plasma gonadotropins during clomiphene induced ovulatory cycles. American journal of obstetrics and gynecology, 102(2), 284-290

Wu, C. H., 1977. Plasma hormones in clomiphene citrate therapy. Obstetrics and gynecology, 49(4), 443-448.

Elnashar, A., Abdelmageed, E., Fayed, M. and Sharaf, M., 2006. Clomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled study. Human Reproduction, 21(7), 1805-1808.

Gorry, A., White, D. M. and Franks, S., 2006. Infertility in polycystic ovary syndrome. Endocrine, 30(1), 27-33.

Shaheen, R., Subhan, F., Sultan, S., Subhan, K. and Tahir, F., 2010. Prevalence of infertility in a cross section of Pakistani population. Pakistan J Zool, 42(4), 389-393.

Yusuf, L., 2016. Depression, anxiety and stress among female patients of infertility; A case control study. Pakistan journal of medical sciences, 32(6), 1340.

Spandana, J. C., 2017. A study on the clinical, biochemical and hormonal profile of polycystic ovary syndrome patients attending tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 6(5), 1986-1992.

Bheem, P., Dinesh, P. and NC, S., 2015. A study on serum FSH, LH and Prolactin Levels Among infertile women. International Journal of Medical Research and Health Sciences, 4(4), 876-878.

Xi, W., Liu, S., Mao, H., Yang, Y., Xue, X. and Lu, X., 2015. Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study. Drug design, development and therapy, 9, 6001

Al-Shaikh, S. F., Al-Mukhatar, E. J., Al-

Zubaidy, A. A., Al-Rubaie, B. J. and AlKhuzaee, L., 2017. Use of clomiphene or letrozole for treating women with polycystic ovary syndrome related subfertility in Hilla city.

Middle East Fertility Society Journal, 22(2), 105110.

Ben-Chioma, A. E. and Tamuno-Emine, D. G., 2015. Evaluation of female fertility hormone profile in women with primary and secondary infertility. International Journal of Science and Research, 4(10), 1583-1585.

Al-Inany, H., Azab, H., El-Khayat, W., Nada, A., El-Khattan, E. and Abou-Setta, A. M., 2010. The effectiveness of clomiphene citrate in LH surge suppression in women undergoing IUI: a randomized controlled trial. Fertility and sterility, 94(6), 2167-2171

Kawwass, J. F., Loucks, T. L. and Berga, S. L., 2010. An algorithm for treatment of infertile women with polycystic ovary syndrome. Middle East Fertility Society Journal, 15(4), 231-239.

Meenakumari, K. J., Agarwal, S., Krishna, A. and Pandey, L. K., 2004. Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome. Brazilian journal of medical and biological research, 37(11), 1637-1644.

Emokpae, M. A., Uadia, P. O. and Mohammed, A. Z., 2005. Hormonal evaluations and endometrial biopsy in infertile women in Kano, Northern Nigeria: A comparative study, 100102.

Published

09-03-2023

How to Cite

Tariq, T., Imran, M., Cheema, F. K., Ashraf, A., Haleema, S., & Arshad, A. (2023). Role of clomiphene citrate in anovulation and hormonal imbalance of patients with polycystic ovarian syndrome. International Journal of Health Sciences, 6(S9), 4776–4783. https://doi.org/10.53730/ijhs.v6nS9.14043

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