Utility of biochemistry in evaluation of tuberculous effusion
Keywords:
tuberculosis, pleural effusion, PCRAbstract
Background: Tuberculosis is second most common cause of pleural effusion. Chest pain, dyspnea, x-ray findings and clinical examination draw a suspicion oftuberculosis but clinicians need reliable and low cost tests todiagnose tuberculosis in pleural effusion. Method: 41 samples of clinically known tuberculous pleural effusion were taken in one year. All samples were tested by ziehlneelsen staining, adenosine deaminase, routine microscopy, and polymerase chain reaction. Results are analysed. Conclusion: It has been found, although PCR is highest sensitive and specific tool but due to high cost and unavailability at many facilities, combination of ADA and R/M can be doneto diagnose tuberculous pleural effusion, which will decrease the cost and time for diagnostic tests.
Downloads
References
Jain J, Jadhao P, Banait S, Salunkhe P (2021) Diagnostic accuracy of GeneXpert MTB/RIFassay for detection of tubercular pleural effusion.PLoS ONE 16(6): e0251618. https://doi.org/10.1371/journal.pone.0251618
Vorster et al. Tuberculous pleural effusions: advances and controversies10.3978/j.issn.2072-1439.2015.02.18 http://dx.doi.org/10.3978/j.issn.2072-1439.2015.02.18.
Diagnostic tools in tuberculous pleurisy: a direct comparative study. A.H. Diacon,
B.W. Van de Wal, C. Wyser, J.P. Smedema, J. Bezuidenhout, C.T. Bolliger, G. Walzl. #ERS Journals Ltd 2003.
Yi-Chun Lai 1y, Shih-Chieh Chang 1y *, Mei-Kang Yuan , Jiun-I Lai , Po-Chou Lin , Li-ChiaoKuo,Cheng-Yu Chang , Yu-Chang Liu , Gau-Jun Tang,Tuberculous Pleural Effusion in the Elderly, doi:10.1016/j.ijge.2012.01.029.
KanZhai, Yong Lu, Huan-Zhong Shi, Tuberculous pleural effusion, J Thorac Dis 2016;8(7):E486-E494,http://dx.doi.org/10.21037/jtd.2016.05.87
Chawla K, Kumar A, Shenoy VP, et al. Evaluation of polymerase chain reaction and pleural fluid adenosine deaminase levels for the diagnosis of tuberculous pleural effusion. J. Evolution Med. Dent. Sci. 2019;8(43):3258-3262, DOI: 10.14260/jemds/2019/706
Aggarwal AN, Agarwal R, Sehgal IS, Dhooria S. Adenosine deaminase for diagnosis of tuberculous pleural effusion: A systematic review and meta-analysis. PLoS One. 2019 Mar 26;14(3):e0213728. doi: 10.1371/journal.pone.0213728. PMID: 30913213; PMCID: PMC6435228.
Z. Huo et al. / International Journal of Infectious Diseases 81 (2019) 38–42. https://doi.org/10.1016/j.ijid.2019.01.045 1201-9712/© 2019 Published by Elsevier Ltd.
Tay and Tee BMC Infectious Diseases 2013, 13:546, Factors affecting pleural fluid adenosine deaminase level and the implication on the diagnosis of tuberculous pleural effusion: a retrospective cohort study,http://www.biomedcentral.com/1471-2334/13/546
Published
How to Cite
Issue
Section
Copyright (c) 2021 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
